Abstract：
:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism underlying postischemic myocardial dysfunction. We tested this hypothesis in nine anesthetized, vagotomized dogs with left cardiac sympathetic nerve stimulation (CSNS) at 1, 2, 5, 10, and 20 Hz and compared this response to that of intravenous norepinephrine infusion (NE, 0.5-1 microgram/kg.min). Regional myocardial wall thickness was measured using sonomicrometry, and mean systolic wall thickening velocity (MSTV) was determined. CSNS was performed before and at 0, 1, 2, 3, 4, 8, 12, 16, 20, and 24 h after release of a 15 min occlusion of a left circumflex coronary artery branch. Before coronary artery occlusion MSTV was increased in a frequency-dependent way from 7.5 +/- 2.7 (S.D.) (rest) to 8.1 +/- 3.1 (1 Hz), 9.4 +/- 3.2 (2 Hz), 11.4 +/- 2.7 (5 Hz), 13.4 +/- 2.4 (10 Hz), and 16.8 +/- 2.1 (20 Hz) by CSNS, and to 12.6 +/- 3.4 mm/s by NE. Immediately upon reperfusion CSNS increased MSTV from 2.9 +/- 2.0 to 2.9 +/- 2.8, 4.1 +/- 3.0, 5.4 +/- 4.6, 6.9 +/- 4.5 and 9.4 +/- 5.9, and NE increased MSTV to 7.8 +/- 1.9 mm/s. Baseline function recovered over 24 h, as did the response to CSNS and NE. Since the recovery of baseline function paralleled the increases in regional contractile function achieved by CSNS or NE, we conclude that there is no impairment of sympathetic neurotransmission in the stunned myocardium.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Schulz R,Frehen D,Heusch Gdoi
10.1007/978-3-662-11038-6_22subject
Has Abstractpub_date
1990-01-01 00:00:00pages
267-80eissn
0300-8428issn
1435-1803journal_volume
85 Suppl 1pub_type
杂志文章abstract：AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...
journal_title：Basic research in cardiology
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doi：10.1007/s00395-006-0600-9
更新日期：2006-09-01 00:00:00
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journal_title：Basic research in cardiology
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doi：10.1007/BF01906958
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1985-07-01 00:00:00
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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doi：10.1007/BF00801965
更新日期：1992-03-01 00:00:00
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journal_title：Basic research in cardiology
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更新日期：1999-12-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1987-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-08390-1_27
更新日期：1987-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01927866
更新日期：1976-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00797913
更新日期：1995-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908160
更新日期：1981-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01923191
更新日期：1983-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907975
更新日期：1989-05-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Basic research in cardiology
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doi：10.1007/BF01906959
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0092-5
更新日期：2010-07-01 00:00:00
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journal_title：Basic research in cardiology
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doi：10.1007/s00395-012-0307-z
更新日期：2012-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:Sarcoplasmic reticulum (SR) from left ventricles of rats that developed spontaneous hypertension was studied in vitro. Similar increases of left ventricular mass were found when grouping the animals into mild and severe hypertensives (average systolic arterial pressure of 168 +/- 4 and 202 +/- 6 mmHg, respectively). T...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907362
更新日期：1988-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788540
更新日期：1995-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908148
更新日期：1984-07-01 00:00:00
abstract：:The relationship between ischemic contracture and no-reflow phenomenon was studied in 59 isolated rat hearts during global ischemia. The contracture was measured by a water-filled balloon catheter placed in the left ventricular lumen. The time of onset of contracture was changed by preischemic infusion with buffer con...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02005340
更新日期：1982-07-01 00:00:00
