Abstract：
:The relationship between ischemic contracture and no-reflow phenomenon was studied in 59 isolated rat hearts during global ischemia. The contracture was measured by a water-filled balloon catheter placed in the left ventricular lumen. The time of onset of contracture was changed by preischemic infusion with buffer containing 0.5 mmoles/l iodoacetate (IAA) in order to get early contracture, and by hypothermia which delayed the development of contracture. The first signs of contracture were noticed in normothermia (37 degrees C) at 11 minutes, in hypothermia (26 degrees C) at 25 minutes, and in the IAA-infused group at 3 minutes. The completion of contracture occurred in these groups at 25, 90 and 11 minutes, respectively. The myocardial perfusability was tested at the pre- and postcontracture state by infusing 0.1% fluorescein in isotonic saline into the cannulated aortic root. The myocardial area perfused with fluorescein was quantified in colour photographs taken under ultraviolet light of frozen whole-heart sections. The myocardial perfusion - expressed ad percent of myocardial area - was 99% at the precontracture state in normothermia, 95% in hypothermia and 100% in the IAA-infused group. At the postcontracture state, the myocardial perfusion in these groups was 80, 56 and 18%, respectively. It was concluded that the no-reflow phenomenon in isolated rat heart is closely associated with the development of myocardial contracture during global ischemia.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Lipasti JA,Nevalainen TJ,Alanen KAdoi
10.1007/BF02005340subject
Has Abstractpub_date
1982-07-01 00:00:00pages
404-10issue
4eissn
0300-8428issn
1435-1803journal_volume
77pub_type
杂志文章abstract：:Ischaemic preconditioning is one of the most potent experimental modalities known to decrease infarct size after ischaemia and reperfusion. Much interest has been stimulated by the phenomenon of remote ischaemic conditioning (RIC), in which the preconditioning stimulus is applied to a limb remote from the heart to sti...
journal_title：Basic research in cardiology
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更新日期：2013-09-01 00:00:00
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1986-01-01 00:00:00
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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更新日期：2009-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02191527
更新日期：1991-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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更新日期：2007-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788712
更新日期：1996-09-01 00:00:00
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pub_type： 杂志文章,撤回出版物
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更新日期：2018-04-18 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050169
更新日期：2000-04-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907862
更新日期：1985-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2005-03-01 00:00:00
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更新日期：2009-01-01 00:00:00
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更新日期：2011-01-01 00:00:00
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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更新日期：1987-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1977-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：1993-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：2019-09-09 00:00:00
abstract：:Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2...
journal_title：Basic research in cardiology
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