Abstract:
:Coronary artery disease causes an increase in glutamate uptake and alanine output by the heart. We assessed the effects of acute myocardial ischemia on alanine and glutamate exchange and ammonia production in 10 anesthetized open-chest domestic swine (46.9 +/- 0.7 kg). Coronary blood flow was controlled through an extracorporal perfusion circuit. After a nonischemic control period (aerobic) the blood flow in the left anterior descending coronary artery was reduced by 60%. Arterial and anterior interventricular venous samples where drawn before and during 35 min of ischemia. Subendocardial blood flow, measured using radiolabeled microspheres, decreased from 1.27 +/- 0.16 to 0.25 +/- 0.09 (ml/g)/min, and left-ventricular wall-thickening fell to 47% of aerobic values. Ischemia resulted in a significant increase in the rate of glucose uptake (p less than 0.05) and a switch to net lactate production (p less than 0.01). Ischemia did not affect the rates of alanine output (-0.9 +/- 1.0 vs. -0.3 +/- 0.3 mumol/min) or glutamate uptake (-0.4 +/- 1.1 vs. 0.3 +/- 0.6 mumol/min), but did increase the venous-arterial difference for ammonia (-4.1 +/- 4.1 to 52.7 +/- 5.5 microM, p less than 0.0001) and the ammonia output (-0.33 +/- 0.24 to 1.34 +/- 0.14 mumol/min, p less than 0.0001). In conclusion, acute ischemia did not stimulate greater alanine output or glutamate uptake. However, acute ischemia did cause an increase in anaerobic glycolysis rate and ammonia output, which reflects a profound disruption in myocardial energy metabolism.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Hacker TA,Hall JL,Stone CK,Stanley WCdoi
10.1007/BF00801965keywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
184-92issue
2eissn
0300-8428issn
1435-1803journal_volume
87pub_type
杂志文章abstract::Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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journal_title:Basic research in cardiology
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doi:10.1007/s00395-011-0218-4
更新日期:2011-11-01 00:00:00
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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doi:10.1007/BF01906671
更新日期:1983-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02650875
更新日期:1989-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788873
更新日期:1993-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/BF02070160
更新日期:1983-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00395-003-0454-3
更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00395-018-0713-y
更新日期:2019-01-11 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950070015
更新日期:2000-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,随机对照试验
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更新日期:2005-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
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更新日期:2001-11-01 00:00:00
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journal_title:Basic research in cardiology
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908177
更新日期:1985-07-01 00:00:00
abstract:AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-006-0600-9
更新日期:2006-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:2019-08-06 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0552-7
更新日期:2016-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02005340
更新日期:1982-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02001396
更新日期:1980-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00795385
更新日期:1992-01-01 00:00:00