Significance of geometrical reference models of the left ventricle for a new concept of evaluation of cardiac pumping function.

abstract：:Myocardial ischemia and infarction are the most common substrates for life-threatening ventricular tachyarrhythmias. Experimental and clinical evidence suggests that enhanced activity of the sympathetic nervous system plays an important role in the genesis of ischemia-related arrhythmias. In animal experiments, beta-b...

journal_title：Basic research in cardiology

authors： Haverkamp W,Gülker H,Hindricks G,Breithardt G

更新日期：1990-01-01 00:00:00

abstract：:In order to clarify the genesis of the characteristic pressure and flow pulse contours of the common carotid artery of man, at first transcutaneous pulse recordings were carried out on healthy resting subjects during breathing of room air and of a mixture of 95% O2 and 5% CO2 (Carbogen). The latter was used to cause v...

journal_title：Basic research in cardiology

authors： Busse R,Bauer RD,Schabert A,Summa Y,Zinecker U,Wetterer E

更新日期：1977-11-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...

journal_title：Basic research in cardiology

authors： Choudhury S,Bae S,Ke Q,Lee JY,Kim J,Kang PM

更新日期：2011-05-01 00:00:00

abstract：:The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxan...

journal_title：Basic research in cardiology

authors： Kiviluoma KT,Karhunen M,Lapinlampi T,Peuhkurinen KJ,Hassinen IE

更新日期：1988-07-01 00:00:00

abstract：:Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 month...

journal_title：Basic research in cardiology

authors： Rakusan K,Hrdina PW,Turek Z,Lakatta EG,Spurgeon HA,Wolford GD

更新日期：1984-07-01 00:00:00

abstract：:Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (p...

journal_title：Basic research in cardiology

authors： Schad H,Heimisch W,Barankay A,Hesse S,Mendler N

更新日期：1990-05-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...

journal_title：Basic research in cardiology

authors： Salie R,Moolman JA,Lochner A

更新日期：2012-09-01 00:00:00

abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...

journal_title：Basic research in cardiology

authors： Birnbaum Y,Tran D,Bajaj M,Ye Y

更新日期：2019-08-06 00:00:00

abstract：:Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...

journal_title：Basic research in cardiology

authors： Müller-Ehmsen J,Nickel J,Zobel C,Hirsch I,Bölck B,Brixius K,Schwinger RH

更新日期：2003-03-01 00:00:00

abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...

journal_title：Basic research in cardiology

authors： Amitzur G,Manoach M,Weinstock M

更新日期：1984-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of hedgehog (Hh) signaling molecules and the chemotactic activity of Sonic hedgehog (Shh) in monocytes from control (CTR) and diabetic patients with or without coronary artery disease (CAD). Previously several studies demonstrated that exogenous administratio...

journal_title：Basic research in cardiology

authors： Dunaeva M,Voo S,van Oosterhoud C,Waltenberger J

更新日期：2010-01-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00

abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...

journal_title：Basic research in cardiology

authors： Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte S

更新日期：2016-07-01 00:00:00

abstract：:We have characterized the aerobic blood-perfused isolated heart model evaluating the hemodynamics and metabolism of both the blood donor animal and the isolated organ. Anaesthesia of the blood donor with sodium pentobarbital (30 mg/kg) increases arterial concentration of non esterified fatty acids (NEFA) from 80 +/- 6...

journal_title：Basic research in cardiology

authors： Pasini E,Solfrini R,Bachetti T,Marino M,Bernocchi P,Visioli F,Ferrari R

更新日期：1999-06-01 00:00:00

abstract：:Since the discovery of a novel mechanism of cell death that differs from traditional necrosis, i.e., apoptosis, there have been numerous studies concluding that increased apoptosis augments myocardial infarction and heart failure and that limiting apoptosis protects the heart. Importantly, the vast majority of cells i...

journal_title：Basic research in cardiology

authors： Jose Corbalan J,Vatner DE,Vatner SF

更新日期：2016-05-01 00:00:00

abstract：:Although epicardial blood flow can be restored by an early intervention in most cases, a lack of adequate reperfusion at the microvascular level is often a limiting prognostic factor of acute myocardial infarction (AMI). Our group has recently found that paracrine factors secreted from apoptotic peripheral blood monon...

journal_title：Basic research in cardiology

authors： Hoetzenecker K,Assinger A,Lichtenauer M,Mildner M,Schweiger T,Starlinger P,Jakab A,Berényi E,Pavo N,Zimmermann M,Gabriel C,Plass C,Gyöngyösi M,Volf I,Ankersmit HJ

更新日期：2012-09-01 00:00:00

abstract：:Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...

journal_title：Basic research in cardiology

authors： Bax NA,van Oorschot AA,Maas S,Braun J,van Tuyn J,de Vries AA,Groot AC,Goumans MJ

更新日期：2011-09-01 00:00:00

abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...

journal_title：Basic research in cardiology

authors： Murthy VK,Bauman MD,Shipp JC

更新日期：1983-05-01 00:00:00

abstract：:The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...

journal_title：Basic research in cardiology

authors： Warltier DC,Hardman HF,Brooks HL,Gross GJ

更新日期：1983-11-01 00:00:00

abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...

journal_title：Basic research in cardiology

authors： Szibor M,Holtz J

更新日期：2003-07-01 00:00:00

abstract：:Dietary intake of unsaturated fatty acid of eicosapentaenoic acid (EPA) is thought to reduce the size and incidence of myocardial infarction. These beneficial effects are postulated to be due to chronic antithrombotic properties of EPA itself. We studied the possible direct effects of EPA on vascular smooth muscle as ...

journal_title：Basic research in cardiology

authors： Yanagisawa A,Lefer AM

更新日期：1987-03-01 00:00:00

abstract：:Short repeated cycles of peripheral ischemia/reperfusion (I/R) can protect distant organs from subsequent prolonged I/R injury; a phenomenon known as remote ischemic preconditioning (RIPC). A RIPC-mediated release of humoral factors might play a key role in this protection and vascular endothelial cells are potential ...

journal_title：Basic research in cardiology

authors： Weber NC,Riedemann I,Smit KF,Zitta K,van de Vondervoort D,Zuurbier CJ,Hollmann MW,Preckel B,Albrecht M

更新日期：2015-03-01 00:00:00

abstract：:This study was aimed to assess the relationship among the voltage-dependent processes underlying the excitation-contraction coupling, viz. force restitution (FR), transmembrane Ca fluxes and Ca release. The experiments (n = 22) were performed on voltage-clamped dog trabeculae in which force and slow inward current wer...

journal_title：Basic research in cardiology

authors： Bravený P,Simurda J,Simurdová M

更新日期：1992-09-01 00:00:00

abstract：:To study the signaling mechanisms which mediate ventricular hypertrophy, we utilized the induction of the ANF gene as a marker of the hypertrophic response. The induction of the atrial natriuretic factor gene (ANF) is one of the most conserved features of ventricular hypertrophy, occurring in multiple species (mouse, ...

journal_title：Basic research in cardiology

authors： Chien R

更新日期：1992-01-01 00:00:00

abstract：:Sympathetic neural remodeling, which involves the inflammatory response, plays an important role in ventricular arrhythmias (VAs) after myocardial infarction (MI). Adrenergic receptors on macrophages potentially modulate the inflammatory response. We hypothesized that the increased level of catecholamines activates ma...

journal_title：Basic research in cardiology

authors： Lyu J,Wang M,Kang X,Xu H,Cao Z,Yu T,Huang K,Wu J,Wei X,Lei Q

更新日期：2020-08-07 00:00:00

abstract：:Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...

journal_title：Basic research in cardiology

authors： Steinmann CM,Lochner A,Niesler RA

更新日期：1987-05-01 00:00:00

abstract：:Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...

journal_title：Basic research in cardiology

authors： Andreadou I,Iliodromitis EK,Szabo C,Papapetropoulos A

更新日期：2015-09-01 00:00:00

abstract：:There is a growing need for pharmacological agents to manage cardiovascular disease in the rapidly growing elderly population. Here, we determine if acetaminophen is efficacious in decreasing age-related increases in cardiac reactive oxygen species (ROS) and apoptosis in aging Fischer 344 X Brown Norway rats. Compared...

journal_title：Basic research in cardiology

authors： Kakarla SK,Fannin JC,Keshavarzian S,Katta A,Paturi S,Nalabotu SK,Wu M,Rice KM,Manzoor K,Walker EM Jr,Blough ER

更新日期：2010-07-01 00:00:00

abstract：:The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...

journal_title：Basic research in cardiology

authors： Piao L,Li J,McLerie M,Lopatin AN

更新日期：2007-09-01 00:00:00