Abstract:
:1. Studies on three models of cardiac hypertrophy (aortic constriction, application of isoproterenol, daily administrations of 3,3'5-triiodo-L-thyronine, respectively) reveal that the enhancement of de novo synthesis of adenine nucleotides occurs very early during the development of cardiac hypertorphy and always precedes the increase of protein synthesis. Therefore, it seems likely that the accelerated synthesis of adenine nucleotides is an important factor among those metabolic processes involved in the stimulation of protein synthesis in the hypertrophying heart. 2. As far as the mechanism for the observed enhancement of adenine nucleotide synthesis is concerned, it has been demonstrated that the available pool of 5-phosphoribosyl-l-pyrophosphate, an essential precursor substance of de novo synthesis, is increased in the hypertrophying heart due to isoproterenol and 3,3'5-triiodo-L-thyronine, respectively.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Zimmer HG,Gerlach Edoi
10.1007/BF01906368keywords:
subject
Has Abstractpub_date
1977-03-01 00:00:00pages
241-6issue
2-3eissn
0300-8428issn
1435-1803journal_volume
72pub_type
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