Effects of ischemic preconditioning on the release of cardiac troponin T in isolated rat hearts.

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...

journal_title：Basic research in cardiology

authors： Love MP,McMurray JJ

更新日期：1996-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...

journal_title：Basic research in cardiology

authors： Hoffmann S,Clauss S,Berger IM,Weiß B,Montalbano A,Röth R,Bucher M,Klier I,Wakili R,Seitz H,Schulze-Bahr E,Katus HA,Flachsbart F,Nebel A,Guenther SP,Bagaev E,Rottbauer W,Kääb S,Just S,Rappold GA

更新日期：2016-05-01 00:00:00

abstract：:The flow pattern and the paths of fluid particles in a saccular aneurysm located at the bifurcation of an intracranial arterial segment are investigated with a numerical method. A normal physiological flow pattern was assumed as input to the studied segment. The theoretical study is carried out for two different Reyno...

journal_title：Basic research in cardiology

authors： Perktold K,Kenner T,Hilbert D,Spork B,Florian H

更新日期：1988-01-01 00:00:00

abstract：:Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...

journal_title：Basic research in cardiology

authors： Reffelmann T,Kloner RA

更新日期：2003-09-01 00:00:00

abstract：:An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...

journal_title：Basic research in cardiology

authors： Grubeck-Loebenstein B,Korn A,Waldhäusl W

更新日期：1981-05-01 00:00:00

abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...

journal_title：Basic research in cardiology

authors： Regitz-Zagrosek V,Fielitz J,Fleck E

更新日期：1998-01-01 00:00:00

abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...

journal_title：Basic research in cardiology

authors： D'Alonzo AJ,Hess TA,Darbenzio RB,Sewter JC,Conder ML,McCullough JR

更新日期：1994-03-01 00:00:00

abstract：:Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...

journal_title：Basic research in cardiology

authors： Heusch G

更新日期：2019-10-15 00:00:00

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting,...

journal_title：Basic research in cardiology

authors： Valassis G,Pragst I,Adolfs C,Paclik D,Wiens F,Vogel-Wiens C,Milz S,Gonschior P

更新日期：2002-03-01 00:00:00

abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...

journal_title：Basic research in cardiology

authors： Stock W,Geppert E,Haase W,Isselhard W

更新日期：1976-03-01 00:00:00

abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...

journal_title：Basic research in cardiology

authors： Seitz WS,Spiel MS,Operschall J,Pachinger O,Klicpera M

更新日期：1983-01-01 00:00:00

abstract：:Isolated cells obtained from adult myocardium are proving invaluable for a wide range of studies concerned with the mechanisms underlying many important cardiological processes. Although care must always be taken to ensure that the single myocyte is an appropriate model for the particular question to be researched, it...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：:Short repeated cycles of peripheral ischemia/reperfusion (I/R) can protect distant organs from subsequent prolonged I/R injury; a phenomenon known as remote ischemic preconditioning (RIPC). A RIPC-mediated release of humoral factors might play a key role in this protection and vascular endothelial cells are potential ...

journal_title：Basic research in cardiology

authors： Weber NC,Riedemann I,Smit KF,Zitta K,van de Vondervoort D,Zuurbier CJ,Hollmann MW,Preckel B,Albrecht M

更新日期：2015-03-01 00:00:00

abstract：:We have characterized the aerobic blood-perfused isolated heart model evaluating the hemodynamics and metabolism of both the blood donor animal and the isolated organ. Anaesthesia of the blood donor with sodium pentobarbital (30 mg/kg) increases arterial concentration of non esterified fatty acids (NEFA) from 80 +/- 6...

journal_title：Basic research in cardiology

authors： Pasini E,Solfrini R,Bachetti T,Marino M,Bernocchi P,Visioli F,Ferrari R

更新日期：1999-06-01 00:00:00

abstract：:Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...

journal_title：Basic research in cardiology

authors： Wouters PF,Van de Velde M,Van Aken H,Flameng W

更新日期：1996-03-01 00:00:00

abstract：:In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous el...

journal_title：Basic research in cardiology

authors： Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram K

更新日期：1993-01-01 00:00:00

abstract：:Low-flow perfusion of paced (5 Hz) rat heart Langendorff preparation with Tyrode solution for 60 min caused a reduction or disappearance of left ventricular pressure amplitude. After 60 min of low-flow perfusion myocardial concentrations of high energy phosphates, as well as the energy charged potential, were diminish...

journal_title：Basic research in cardiology

authors： Streller I,Walland A

更新日期：1990-01-01 00:00:00

abstract：:Cardiac excitation-contraction (EC) coupling consumes vast amounts of cellular energy, most of which is produced in mitochondria by oxidative phosphorylation. In order to adapt the constantly varying workload of the heart to energy supply, tight coupling mechanisms are essential to maintain cellular pools of ATP, phos...

journal_title：Basic research in cardiology

authors： Maack C,O'Rourke B

更新日期：2007-09-01 00:00:00

abstract：:The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...

journal_title：Basic research in cardiology

authors： Buss DD,Hyde DM,Steffey EP

更新日期：1983-09-01 00:00:00

abstract：:Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2...

journal_title：Basic research in cardiology

authors： Adam O,Löhfelm B,Thum T,Gupta SK,Puhl SL,Schäfers HJ,Böhm M,Laufs U

更新日期：2012-09-01 00:00:00

abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...

journal_title：Basic research in cardiology

authors： Ferreira R,Moreira-Gonçalves D,Azevedo AL,Duarte JA,Amado F,Vitorino R

更新日期：2015-01-01 00:00:00

abstract：:Elucidation of the subcellular mechanism of myocardial ischemic preconditioning should be facilitated by precise knowledge of the biology of the cardioprotective response. Any proposed molecular mechanism for preconditioning must be initiated during the required ischemic stress period. The studies reported in this pap...

journal_title：Basic research in cardiology

authors： Schwartz LM,Jennings RB,Reimer KA

更新日期：1997-04-01 00:00:00

abstract：:N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...

journal_title：Basic research in cardiology

authors： Fang J,Hu F,Ke D,Yan Y,Liao Z,Yuan X,Wu L,Jiang Q,Chen L

更新日期：2016-05-01 00:00:00

abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...

journal_title：Basic research in cardiology

authors： Morano I

更新日期：1992-01-01 00:00:00

abstract：:In the newborn several situations of hyperinsulinism can be associated with myocardial hypertrophy and increased contractility. Insulin and the insulin-like growth factors (IGF) are derived from a common ancestral molecule. Insulin exerts mainly metabolic action, whereas the IGFs promote cell multiplication and differ...

journal_title：Basic research in cardiology

authors： Vetter U,Kupferschmid C,Lang D,Pentz S

更新日期：1988-11-01 00:00:00

abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...

journal_title：Basic research in cardiology

authors： Zhang YH,Sun HY,Chen KH,Du XL,Liu B,Cheng LC,Li X,Jin MW,Li GR

更新日期：2012-09-01 00:00:00

abstract：:Cardiac hypertrophy which occurs during chronic mechanical overload is one of the numerous examples of biological adaptation to environmental requirements. As such, it is obtained at random by trial and error, and adaptation represents the sum of various modifications in gene expression, including the shift in isoform...

journal_title：Basic research in cardiology

authors： Chevalier B,Charlemagne D,Callens-el Amrani F,Carre F,Moalic JM,Delcayre C,Mansier P,Swynghedauw B

更新日期：1992-01-01 00:00:00

abstract：:A new experimental in-vitro model is described, which was used for studying prostacyclin (PGI2)-thromboxane A2 (TXA2)-interactions. Langendorff hearts of guinea pigs are perfused at constant volume with Krebs-Henseleit buffer and washed human platelets (4 x 10(8)/min). PGI2 and TXA2 release are measured by bioassay. T...

journal_title：Basic research in cardiology

authors： Köhler P,Schrör K

更新日期：1981-09-01 00:00:00