Kinetics of cellular uptake of tracers used in myocardial scintigraphy.

abstract：:For the quantitative evaluation of myocardial damage induced by isoprenaline (ISO) a method based on the uptake of 203Hg-labelled Mercurascan (MSC) in the heart was used. The increase of myocardial uptake of MSC in ISO-treated rats over control values was very rapid and might be directly proportional to the number of ...

journal_title：Basic research in cardiology

authors： Faltová E,Mráz M,Kronrád L,Protivová L,Sedivý J

更新日期：1977-09-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...

journal_title：Basic research in cardiology

authors： Hoffmann S,Clauss S,Berger IM,Weiß B,Montalbano A,Röth R,Bucher M,Klier I,Wakili R,Seitz H,Schulze-Bahr E,Katus HA,Flachsbart F,Nebel A,Guenther SP,Bagaev E,Rottbauer W,Kääb S,Just S,Rappold GA

更新日期：2016-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-r...

journal_title：Basic research in cardiology

authors： Wang P,Mao B,Luo W,Wei B,Jiang W,Liu D,Song L,Ji G,Yang Z,Lai YQ,Yuan Z

更新日期：2014-01-01 00:00:00

abstract：:We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...

journal_title：Basic research in cardiology

authors： Wilson DL,Lacerda AE,Kunze DL,Brown AM

更新日期：1985-01-01 00:00:00

abstract：:Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a poorly defined type 2A protein phosphatase-alpha4 intracellular signalling axis. Quantitative PCR analysis revealed that mRNA levels of the type 2A catalytic subunits were differentially exp...

journal_title：Basic research in cardiology

authors： Eleftheriadou O,Boguslavskyi A,Longman MR,Cowan J,Francois A,Heads RJ,Wadzinski BE,Ryan A,Shattock MJ,Snabaitis AK

更新日期：2017-07-01 00:00:00

abstract：:In anaesthetized, artificially respirated mongrel dogs, the intravenous infusion of oxprenolol (0.3 mg and 1 mg/kg over 10 minutes) led to an increase in heart rate and cardiac output. Blood pressure in the pulmonary capillaries and right atrium, and vascular resistance were reduced. The pressure in the aorta was tran...

journal_title：Basic research in cardiology

authors： Stepanek J,Brunner H

更新日期：1975-09-01 00:00:00

abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...

journal_title：Basic research in cardiology

authors： Amitzur G,Manoach M,Weinstock M

更新日期：1984-11-01 00:00:00

abstract：:The mechanism of ergonovine-provoked coronary vasospasm is poorly understood. We tested the effect of ergonovine in perfused hearts from normal and cholesterol-fed (18 weeks, 2% cholesterol diet) rabbits in a constant-flow Langendorff perfusion. Aortic perfusion pressure was monitored to measure coronary vascular resi...

journal_title：Basic research in cardiology

authors： von Arnim T,Crea F,Chierchia S,Thompson GR,Maseri A

更新日期：1983-07-01 00:00:00

abstract：:In Langendorff-perfused guinea pig hearts, local myocardial perfusion was evaluated by analysis of FITC-dextran-150 elution kinetics after bolus injection. Locally estimated half-times of the monoexponential elution curves showed good correlation with global undisturbed coronary flow. After ligation of the left anteri...

journal_title：Basic research in cardiology

authors： Rösen R,Marsen A,Klaus W

更新日期：1984-01-01 00:00:00

abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...

journal_title：Basic research in cardiology

authors： Lindner M,Mehel H,David A,Leroy C,Burtin M,Friedlander G,Terzi F,Mika D,Fischmeister R,Prié D

更新日期：2020-07-22 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00

abstract：:Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether st...

journal_title：Basic research in cardiology

authors： Fraccarollo D,Galuppo P,Motschenbacher S,Ruetten H,Schäfer A,Bauersachs J

更新日期：2014-07-01 00:00:00

abstract：:The available data clearly suggest large alterations in myocardial eicosanoid generation during myocardial ischaemia and demonstrate important actions of eicosanoids on myocardial function during ischaemic conditions. These actions include direct effects on the injured myocardium as well as influences on other target ...

journal_title：Basic research in cardiology

authors： Schrör K

更新日期：1987-01-01 00:00:00

abstract：:Therapeutic angiogenesis improves tissue ischemia by supplementing and supporting the intrinsic process of angiogenesis. Besides direct administration of angiogenic growth factor proteins, injection of naked DNA, non-viral vectors and viral vector constructs carrying angiogenic genes have been used. A novel approach i...

journal_title：Basic research in cardiology

authors： Lei Y,Haider HKh,Shujia J,Sim ES

更新日期：2004-03-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00

abstract：:The effects of regional hypoxemia and ischemia on epicardial electrogram were studied in anesthetized, open-chest dogs. The left circumflex artery (LCx) was cannulated and perfused with either arterial blood or hypoxic solution. A contact electrode for recording monophasic action potential (MAP) was applied to the epi...

journal_title：Basic research in cardiology

authors： Ikeno E,Kubota I,Kondo T,Yamaki M,Shibata T,Tomoike H

更新日期：1995-11-01 00:00:00

abstract：:Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...

journal_title：Basic research in cardiology

authors： Weirich J,Antoni H

更新日期：1998-01-01 00:00:00

abstract：:In dog myocardium, the changes in the levels of creatine phosphate, inorganic phosphate, ATP, ADP, AMP, adenosine and inosine with 8 min of ischemia and subsequent reperfusion for 2, 4, 8, 16 and 32 min have been followed. Creatine phosphate and inorganic phosphate recovered completely within a few minutes as did the ...

journal_title：Basic research in cardiology

authors： Van Belle H,Xhonneux R,Flameng W,Wynants J

更新日期：1986-07-01 00:00:00

abstract：:Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...

journal_title：Basic research in cardiology

authors： Hofmann M,Hofmann M,Genth K,Schaper W

更新日期：1980-07-01 00:00:00

abstract：:Ventricular and atrial cardiac muscle cells isolated from the adult rat have been cultured and characterized. Once established in culture these myocytes resemble morphologically their in vivo counterparts except that they are flattened on the surface of the culture flask. These cultured cells possess differentiated ul...

journal_title：Basic research in cardiology

authors： Claycomb WC

更新日期：1985-01-01 00:00:00

abstract：:Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic a...

journal_title：Basic research in cardiology

authors： Kaukel E,Beier W,Lanser K,Sill V

更新日期：1977-09-01 00:00:00

abstract：:Cardiac hypertrophy which occurs during chronic mechanical overload is one of the numerous examples of biological adaptation to environmental requirements. As such, it is obtained at random by trial and error, and adaptation represents the sum of various modifications in gene expression, including the shift in isoform...

journal_title：Basic research in cardiology

authors： Chevalier B,Charlemagne D,Callens-el Amrani F,Carre F,Moalic JM,Delcayre C,Mansier P,Swynghedauw B

更新日期：1992-01-01 00:00:00

abstract：:The influence of norepinephrine on ventricular overdrive suppression and attendant potassium shifts has been studied in isolated perfused canine hearts with complete atrioventricular block. It was found that: 1) there is a potassium loss during the drive and a potassium uptake after the drive); 2) reducing the driving...

journal_title：Basic research in cardiology

authors： Pliam MB,Krellenstein DJ,Brooks CM,Vassalle M

更新日期：1977-01-01 00:00:00

abstract：:The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-i...

journal_title：Basic research in cardiology

authors： Edes I,Piros G,Forster T,Csanady M

更新日期：1987-11-01 00:00:00

abstract：:The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adeny...

journal_title：Basic research in cardiology

authors： Jakobs KH,Minuth M,Bauer S,Grandt R,Greiner C,Zubin P

更新日期：1986-01-01 00:00:00

abstract：:The renin angiotensin system and endothelium-derived vasoactive substances are both important regulators of vascular tone. Recent evidence suggests that the two systems may be tightly interconnected and drugs interfering with one system may also affect the other. Beside the circulating renin angiotensin system, a vasc...

journal_title：Basic research in cardiology

authors： Lüscher TF

更新日期：1993-01-01 00:00:00

abstract：:A new experimental in-vitro model is described, which was used for studying prostacyclin (PGI2)-thromboxane A2 (TXA2)-interactions. Langendorff hearts of guinea pigs are perfused at constant volume with Krebs-Henseleit buffer and washed human platelets (4 x 10(8)/min). PGI2 and TXA2 release are measured by bioassay. T...

journal_title：Basic research in cardiology

authors： Köhler P,Schrör K

更新日期：1981-09-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) from left ventricles of rats that developed spontaneous hypertension was studied in vitro. Similar increases of left ventricular mass were found when grouping the animals into mild and severe hypertensives (average systolic arterial pressure of 168 +/- 4 and 202 +/- 6 mmHg, respectively). T...

journal_title：Basic research in cardiology

authors： Cuneo ME,Grassi de Gende AO

更新日期：1988-05-01 00:00:00

abstract：:The aim of this study was to clarify the role of altered diabetic vascular reactivity in ischaemic heart disease. In diabetic condition, the necrotic area of myocardial infarction was significantly extended and myocardial oedema failed to develop after administration of norepinephrine 2 or 48 hours after ligation of t...

journal_title：Basic research in cardiology

authors： Palik I,Koltai MZ,Kolonics I,Wagner M,Pogátsa G

更新日期：1982-09-01 00:00:00

abstract：:Perfusion of isoprenaline in the dog may induce left ventricular hypertrophy (LVH), and this effect is suppressed by propranolol. Cultured foetal cardiomyocytes exposed to catecholamines show an increase in protein synthesis and RNA turnover. In spontaneously hypertensive rats (SHR), and perhaps in man, sympatholytic ...

journal_title：Basic research in cardiology

authors： Rorive G,Carlier P,Smelten N,Zgheib A

更新日期：1991-01-01 00:00:00