Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue.

abstract：:The influence of changes in pre- and afterload, heart frequency and inotropic state on the difference between right ventricular dP/dtmax measured isovolumically and auxotonically has been investigated in canine heart-lung preparations. Isovolumic systoles were obtained by occluding the pulmonary artery during diastole...

journal_title：Basic research in cardiology

authors： Hoppe H,Schmidt HD,Seitz E

更新日期：1976-09-01 00:00:00

abstract：:Colloidal iron staining, calcium binding and enzyme activities were studied in the isolated rat heart sarcolemma. Colloidal iron staining of the sarcolemma revealed a high density of negatively charged sites associated with the cell surface. This membrane fraction was found to have calcium binding activity at both low...

journal_title：Basic research in cardiology

authors： Matsukubo MP,Singal PK,Dhalla NS

更新日期：1981-01-01 00:00:00

abstract：:The quantitative predominance of free and total cholesterol over the amount of mural calcium is a most significant criterion of healthy human coronary arteries during the whole life span (0-90 years). However, this normal ratio increasingly changes as soon as arteriosclerotic alterations of the coronary walls set in. ...

journal_title：Basic research in cardiology

authors： Frey M,Just H

更新日期：1994-01-01 00:00:00

abstract：:Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...

journal_title：Basic research in cardiology

authors： Gaglione A,Hess OM,Haemmerli C,Suter T,Kirkeeide RL,Osenberg HP,Muser M,Anliker M,Gould KL,Krayenbuehl HP

更新日期：1990-01-01 00:00:00

abstract：:The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 ...

journal_title：Basic research in cardiology

authors： Pissarek M,Goos H,Nöhring J,Graff J,Buller G,Beyerdörfer I,Mest HJ,Lindenau KF,Krause EG

更新日期：1987-11-01 00:00:00

abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...

journal_title：Basic research in cardiology

authors： Schulz R,Frehen D,Heusch G

更新日期：1990-01-01 00:00:00

abstract：:Mobilization of triacylglycerol stored in heart cells is accomplished by the combined action of lysosomal (acid) lipase and microsomal monoacylglycerol lipase or carboxylesterase. Non(heparin)-releasable neutral or alkaline lipase is similar to non(readily)-releasable lipoprotein lipase (LPL). The enzyme is mainly loc...

journal_title：Basic research in cardiology

authors： Hülsmann WC,Stam H,Jansen H

更新日期：1984-05-01 00:00:00

abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...

journal_title：Basic research in cardiology

authors： Ferreira R,Moreira-Gonçalves D,Azevedo AL,Duarte JA,Amado F,Vitorino R

更新日期：2015-01-01 00:00:00

abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...

journal_title：Basic research in cardiology

authors： Orlandi C,Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1986-05-01 00:00:00

abstract：:Cardiac alpha- and beta-adrenoceptors and the positive inotropic effects of several adenylate cyclase dependent and independent agents have been measured in papillary muscle strips from patients without, as well as with moderate and severe heart failure. The number of beta-adrenoceptors was found to be decreased depen...

journal_title：Basic research in cardiology

authors： Erdmann E,Böhm M

更新日期：1989-01-01 00:00:00

abstract：:Using an isolated rat heart preparation (Langendorff perfusion, perfusion pressure 100 cm H2O) the response of the hypertrophied heart (spontaneous hypertensive rats lv/bw ratio 3.6 +/- 0.5) to global normothermic (30 min) and hypothermic (25 degrees C, 120 min) ischemic and cardioplegic arrest and reperfusion (30 min...

journal_title：Basic research in cardiology

authors： Fenchel G,Storf R,Hoffmeister HE,Heller W

更新日期：1986-01-01 00:00:00

abstract：:Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...

journal_title：Basic research in cardiology

authors： Gülch RW,Ebrecht G

更新日期：1987-01-01 00:00:00

abstract：:Atherosclerotic coronary arteries are more calcified in patients with than without chronic kidney disease (CKD). We addressed the potential for coronary microvascular obstruction in patients with and without CKD during stenting for saphenous vein aorto-coronary graft (SVG) stenosis under protection with a distal occlu...

journal_title：Basic research in cardiology

authors： Baars T,Kleinbongard P,Böse D,Konorza T,Möhlenkamp S,Hippler J,Erbel R,Heusch G

更新日期：2012-11-01 00:00:00

abstract：:In this report, we showed that a previous enterovirus exposure in ordinary mice with normal T cell function, but not in T cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. Inoculation of 4-week-old male BALB/c-nu/+ (euthymic and normal T cell function) mice with am...

journal_title：Basic research in cardiology

authors： Kishimoto C,Hiraoka Y,Takada H

更新日期：2001-09-01 00:00:00

abstract：:The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...

journal_title：Basic research in cardiology

authors： Vogt M,Motz W,Strauer BE

更新日期：1991-01-01 00:00:00

abstract：:Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...

journal_title：Basic research in cardiology

authors： Kissling G,Rupp H,Malloy L,Jacob R

更新日期：1982-05-01 00:00:00

abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...

journal_title：Basic research in cardiology

authors： Tang TT,Yuan J,Zhu ZF,Zhang WC,Xiao H,Xia N,Yan XX,Nie SF,Liu J,Zhou SF,Li JJ,Yao R,Liao MY,Tu X,Liao YH,Cheng X

更新日期：2012-01-01 00:00:00

abstract：:Experimental evidence indicates that ischemic glycolysis improves myocardial tolerance to low flow ischemia and anoxia, and cellular membrane disruption signals and/or causes transition to irreversible ischemic injury. The objective of this study was to determine the impact of ischemic glycolysis on membrane integrity...

journal_title：Basic research in cardiology

authors： Askenasy N

更新日期：2001-11-01 00:00:00

abstract：:The mitochondrial electrochemical gradient (Δp), which comprises the pH gradient (ΔpH) and the membrane potential (ΔΨ), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial dysfunction mediates superoxide (·O2-) and H2O2 overproduction leading to oxidative injur...

journal_title：Basic research in cardiology

authors： Kang PT,Chen CL,Lin P,Chilian WM,Chen YR

更新日期：2017-07-01 00:00:00

abstract：:At 36 degrees C and 2 mM [Ca2+]o, single guinea-pig ventricular myocytes were voltage clamped with patch electrodes. When paired pulsing had potentiated the contraction to the maximum, the cells were shock-frozen for electron probe microanalysis (EPMA). Shock-freezing was timed at the end of diastole (-80 mV) or at di...

journal_title：Basic research in cardiology

authors： Wendt-Gallitelli MF,Isenberg G,Voigt T,Ross C

更新日期：1991-01-01 00:00:00

abstract：:We tested the hypotheses that myocardial infarction in mice would lead to progressively worsening heart failure 12-18 weeks later and that exercise testing would provide a suitable means to evaluate left ventricular function sequentially. C57BL/6 mice (n = 69) underwent left coronary artery ligation (n = 50) or thorac...

journal_title：Basic research in cardiology

authors： Bayat H,Swaney JS,Ander AN,Dalton N,Kennedy BP,Hammond HK,Roth DM

更新日期：2002-05-01 00:00:00

abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...

journal_title：Basic research in cardiology

authors： Lange R,Ingwall JS,Hale SL,Alker KJ,Kloner RA

更新日期：1984-07-01 00:00:00

abstract：:Guinea-pig left atria were loaded with 10 microCi 7-[3H]noradrenaline, and noradrenaline release from sympathetic nerve endings was then elicited by refractory period field stimulation. When one pulse of 0.2 ms duration was applied during each refractory period, the resulting transmitter release was halved by 3 x 10(-...

journal_title：Basic research in cardiology

authors： Brasch H

更新日期：1993-11-01 00:00:00

abstract：:Our understanding of what constitutes "normal" collagen organization in wound healing after myocardial injury and how such organization is achieved is still in its infancy. However, once this knowledge has been obtained, it may suggest methods of enhancing or even optimizing healing, and thus provide us with the possi...

journal_title：Basic research in cardiology

authors： Whittaker P

更新日期：1998-01-01 00:00:00

abstract：:Heart failure has been divided into several different forms depending on etiology, clinical course and pathophysiology of left ventricular (LV) dysfunction. Systolic and diastolic dysfunction are characterized by a reduced cardiac output with normal (= diastolic dysfunction) or depressed (= systolic dysfunction) LV pu...

journal_title：Basic research in cardiology

authors： Matter C,Nagel E,Stuber M,Boesiger P,Hess OM

更新日期：1996-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of hedgehog (Hh) signaling molecules and the chemotactic activity of Sonic hedgehog (Shh) in monocytes from control (CTR) and diabetic patients with or without coronary artery disease (CAD). Previously several studies demonstrated that exogenous administratio...

journal_title：Basic research in cardiology

authors： Dunaeva M,Voo S,van Oosterhoud C,Waltenberger J

更新日期：2010-01-01 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00

abstract：:The molecular mechanisms through which ghrelin exerts its cardioprotective effects during cardiac remodeling post-myocardial infarction (MI) are poorly understood. The aim of this study was to investigate whether the cardioprotection mechanisms are mediated by modulation of JAK/STAT signaling and what triggers this mo...

journal_title：Basic research in cardiology

authors： Eid RA,Alkhateeb MA,Eleawa S,Al-Hashem FH,Al-Shraim M,El-Kott AF,Zaki MSA,Dallak MA,Aldera H

更新日期：2018-02-01 00:00:00

abstract：:Migration of CD4-positive lymphocytes into the vessel wall is a critical step in atherogenesis. Recent data suggest that CD4-positive lymphocytes express the nuclear transcription factors Liver-X-Receptor (LXR) alpha and beta with an effect of LXR activators on TH1-cytokine release from these cells. However, the role ...

journal_title：Basic research in cardiology

authors： Walcher D,Vasic D,Heinz P,Bach H,Durst R,Hausauer A,Hombach V,Marx N

更新日期：2010-07-01 00:00:00

abstract：:We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...

journal_title：Basic research in cardiology

authors： Wilson DL,Lacerda AE,Kunze DL,Brown AM

更新日期：1985-01-01 00:00:00