Contractile proteins in globally "stunned" rabbit myocardium.

abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...

journal_title：Basic research in cardiology

authors： Morano I

更新日期：1992-01-01 00:00:00

abstract：:The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...

journal_title：Basic research in cardiology

authors： Warltier DC,Hardman HF,Brooks HL,Gross GJ

更新日期：1983-11-01 00:00:00

abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...

journal_title：Basic research in cardiology

authors： Szibor M,Holtz J

更新日期：2003-07-01 00:00:00

abstract：:X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in "caffeine contracture" with cryosections of normal muscle. Our goal was to find out if it is possible by means of this method to detect changes in the calcium compartmentalization of the myocardial cell occur...

journal_title：Basic research in cardiology

authors： Wendt-Gallitelli MF,Wolburg H,Schlote W,Schwegler M,Holubarsch C,Jacob R

更新日期：1980-01-01 00:00:00

abstract：:In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous el...

journal_title：Basic research in cardiology

authors： Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram K

更新日期：1993-01-01 00:00:00

abstract：:Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Thereby, this compound exerts systemic and preferential renal vasodilation, causing afterload reduction, increases in cardiac output, and improve...

journal_title：Basic research in cardiology

authors： Meinertz T,Drexler H,Just H

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Two types of hemodynamic overload, pressure and volume overload, result in morphologically distinct types of cardiac remodeling. We explored the possibility that distinct hemodynamic overload may differentially activate the signal transduction pathway. METHODS:Pressure and volume overload were induced by tho...

journal_title：Basic research in cardiology

authors： Miyamoto T,Takeishi Y,Takahashi H,Shishido T,Arimoto T,Tomoike H,Kubota I

更新日期：2004-09-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:This study was aimed to assess the relationship among the voltage-dependent processes underlying the excitation-contraction coupling, viz. force restitution (FR), transmembrane Ca fluxes and Ca release. The experiments (n = 22) were performed on voltage-clamped dog trabeculae in which force and slow inward current wer...

journal_title：Basic research in cardiology

authors： Bravený P,Simurda J,Simurdová M

更新日期：1992-09-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...

journal_title：Basic research in cardiology

authors： Salie R,Moolman JA,Lochner A

更新日期：2012-09-01 00:00:00

abstract：:8 mm long sections of common carotid arteries of conscious, freely moving rabbits were electrically stimulated with DC-impulses by chronically implanted gold-electrodes daily for 1/2 h or two times 1/2 h per day for 4--6 weeks. The electrodes were arranged in such a way that the wall was stimulated transmurally, In th...

journal_title：Basic research in cardiology

authors： Betz E,Schlote W

更新日期：1979-01-01 00:00:00

abstract：:Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...

journal_title：Basic research in cardiology

authors： Liedtke AJ,Mahar CQ,Ytrehus K,Mjøs OD

更新日期：1984-09-01 00:00:00

abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...

journal_title：Basic research in cardiology

authors： Regitz-Zagrosek V,Fielitz J,Fleck E

更新日期：1998-01-01 00:00:00

abstract：:Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...

journal_title：Basic research in cardiology

authors： Hofmann M,Hofmann M,Genth K,Schaper W

更新日期：1980-07-01 00:00:00

abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...

journal_title：Basic research in cardiology

authors： Scholz PM,Kedem J,Cheinberg BV,Weiss HR

更新日期：1996-07-01 00:00:00

abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...

journal_title：Basic research in cardiology

authors： Schulz R,Frehen D,Heusch G

更新日期：1990-01-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...

journal_title：Basic research in cardiology

authors： Orlandi C,Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1986-05-01 00:00:00

abstract：:Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...

journal_title：Basic research in cardiology

authors： Bax NA,van Oorschot AA,Maas S,Braun J,van Tuyn J,de Vries AA,Groot AC,Goumans MJ

更新日期：2011-09-01 00:00:00

abstract：:A simplified single-plane angiocardiographic method for the measurement of the left ventricular volumes in the reindeer heart has been developed, on the assumption that the left ventricle forms half a revolution ellipsoid. On the basis of a study of 30 ventricular casts the following formulae were constructed for the ...

journal_title：Basic research in cardiology

authors： Timisjärvi J,Hirvonen L,Kiviniitty K,Linnaluoto M

更新日期：1977-07-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00

abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...

journal_title：Basic research in cardiology

authors： Alakoski T,Ulvila J,Yrjölä R,Vainio L,Magga J,Szabo Z,Licht JD,Kerkelä R

更新日期：2019-01-11 00:00:00

abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...

journal_title：Basic research in cardiology

authors： Keith MC,Tokita Y,Tang XL,Ghafghazi S,Moore JB 4th,Hong KU,Elmore JB,Amraotkar AR,Guo H,Ganzel BL,Grubb KJ,Flaherty MP,Vajravelu BN,Wysoczynski M,Bolli R

更新日期：2015-09-01 00:00:00

abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...

journal_title：Basic research in cardiology

authors： Yonekura K,Eto Y,Yokoyama I,Matsumoto A,Sugiura S,Momomura S,Kirimoto T,Hayashi Y,Omata M,Aoyagi T

更新日期：2000-10-01 00:00:00

abstract：:Alcoholic heart muscle disease is characterized by structural changes which include chamber dilation, ventricular hypertrophy, and myocyte damage. These effects often lead to contractile dysfunction and ultimately to heart failure if alcohol consumption is not terminated. In rat models for heart failure in which heart...

journal_title：Basic research in cardiology

authors： Meehan J,Piano MR,Solaro RJ,Kennedy JM

更新日期：1999-12-01 00:00:00

abstract：:Complete length-tension diagrams of myocardium were measured on isolated papillary muscles of cat right ventricle. These diagrams clearly demonstrate that irrespective of loading conditions there is no uniform maxima curve. As a function of preload the curves of afterloaded isotonic maxima obey totally separate nonlin...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1985-11-01 00:00:00

abstract：:The influence of changes in pre- and afterload, heart frequency and inotropic state on the difference between right ventricular dP/dtmax measured isovolumically and auxotonically has been investigated in canine heart-lung preparations. Isovolumic systoles were obtained by occluding the pulmonary artery during diastole...

journal_title：Basic research in cardiology

authors： Hoppe H,Schmidt HD,Seitz E

更新日期：1976-09-01 00:00:00

abstract：:A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...

journal_title：Basic research in cardiology

authors： Phillis JW,Song D,O'Regan MH

更新日期：2000-04-01 00:00:00

abstract：:Colloidal iron staining, calcium binding and enzyme activities were studied in the isolated rat heart sarcolemma. Colloidal iron staining of the sarcolemma revealed a high density of negatively charged sites associated with the cell surface. This membrane fraction was found to have calcium binding activity at both low...

journal_title：Basic research in cardiology

authors： Matsukubo MP,Singal PK,Dhalla NS

更新日期：1981-01-01 00:00:00

abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...

journal_title：Basic research in cardiology

authors： Takeda N,Ohkubo T,Nakamura I,Suzuki H,Nagano M

更新日期：1987-07-01 00:00:00