Abstract:
:Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention of AMS. For each dose, risk ratios were aggregated using a Mantel-Haenszel fixed effect model. Numbers needed to treat (NNT) to benefit one subject with each dose were calculated for different baseline risks. Modes of ascent were taken as proxies of baseline risks. Twenty-four trials were included; 1011 subjects received acetazolamide 250, 500, or 750 mg day⁻¹; 854 received placebo. When climbing, median speed of ascent was 14 m/h, average AMS rate in controls was 34%, and NNT to prevent AMS with acetazolamide 250, 500, and 750 mg/day compared with placebo was 6.5, 5.9, and 5.3. When ascending by transport and subsequent climbing (speed of ascent 133 m/h) or by transport alone (491 m/h), average AMS rate in controls was 60%, and NNT with acetazolamide 250, 500, and 750 mg/day was 3.7, 3.3, and 3.0. In hypobaric chambers, median speed of ascent was 4438 m/h, average AMS rate in controls was 86%, and NNT with acetazolamide 250, 500, and 750 mg/day was 2.6, 2.3, and 2.1. The risk of paresthesia was increased with all doses. The risk of polyuria and taste disturbance was increased with 500 and 750 mg/day. The degree of efficacy of acetazolamide for the prevention of AMS is limited when the baseline risk is low, and there is some evidence of dose-responsiveness.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Kayser B,Dumont L,Lysakowski C,Combescure C,Haller G,Tramèr MRdoi
10.1089/ham.2011.1084subject
Has Abstractpub_date
2012-06-01 00:00:00pages
82-92issue
2eissn
1527-0297issn
1557-8682journal_volume
13pub_type
杂志文章,meta分析,评审abstract::Wagner, Dale R., Skyler Saunders, Brady Robertson, and John E. Davis. Normobaric hypoxia effects on balance measured by computerized dynamic posturography. High Alt Med Biol. 17:222-227, 2016.-Background/Aim: Equilibrium was measured by computerized dynamic posturography at varying levels of normobaric hypoxia before ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0040
更新日期:2016-09-01 00:00:00
abstract::Otero, Liliana, Patricia Hidalgo, Rafael González, and Carlos A. Morillo. Association of cardiovascular disease and sleep apnea at different altitudes. High Alt Med Biol. 17:336-341, 2016.-We evaluated the prevalence of sleep apnea (SA) in patients with cardiovascular disease (CVD) at different altitudes. A total of 3...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0027
更新日期:2016-12-01 00:00:00
abstract::Shatylo, Valerii B., Tetiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, and Oleg V. Korkushko. Acute hypoxic test in patients with prediabetes. High Alt Med Biol. 17:101-107, 2016.-Prediabetes is a state of impaired carbohydrate metabolism when not all of the symptoms required to label a person as diabetic are pres...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2015.0117
更新日期:2016-06-01 00:00:00
abstract::High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied. To fulfill these objectives...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0031
更新日期:2019-03-01 00:00:00
abstract::Van Iterson, Erik H., Eric M. Snyder, and Bruce D. Johnson. The influence of 17 hours of normobaric hypoxia on parallel adjustments in exhaled nitric oxide and airway function in lowland healthy adults. High Alt Med Biol. 18:1-10, 2017.-Currently, there is a disparate understanding of the role that normobaric hypoxia ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0086
更新日期:2017-03-01 00:00:00
abstract::Chronic hypoxia has a profound effect on uterine artery adaptation to pregnancy. The present studies tested the hypothesis that pregnant kinase C (PKC) differentially regulates alpha(1)-adrenoceptor-mediated contractions and Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to h...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1076
更新日期:2010-07-01 00:00:00
abstract:AIMS:Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive fa...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2015.0022
更新日期:2015-09-01 00:00:00
abstract::Neurological disturbances may be present at high altitude independently of high altitude cerebral edema. We report here the case of a patient who experienced for the first time generalized seizures after spending a night at an altitude of 5200 m, with no preceding symptoms of acute mountain sickness. An initial CT sca...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2006.7.81
更新日期:2006-04-01 00:00:00
abstract::The present study compares the changes in ventilation in response to sustained hypobaric hypoxia and acute normobaric hypoxia between subjects susceptible to high altitude pulmonary edema (HAPE-S) and control subjects (C-S). Seven HAPE-S and five C-S were exposed to simulated high altitude of 4000 m for 23 h in a hypo...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702902320604241
更新日期:2002-10-01 00:00:00
abstract:: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0128
更新日期:2019-06-01 00:00:00
abstract::The aim of the present study was to elucidate (1) the cardiovascular adaptations and response to hypoxic stimuli during short-term intermittent hypoxia and (2) whether the change in cardiovascular response to hypoxia is correlated to the change in hypoxic ventilatory chemosensitivity. Fourteen subjects were decompress...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/152702901753397063
更新日期:2001-01-01 00:00:00
abstract::The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1053
更新日期:2008-04-01 00:00:00
abstract::Gou, Qiling, Rufeng Shi, Xin Zhang, Qingtao Meng, Xinran Li, Xi Rong, Zhabu Gawa, Nage Zhuoma, and Xiaoping Chen. The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan Province, China. High Alt Med Biol. 21:327-335, 2020. Background: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0022
更新日期:2020-12-01 00:00:00
abstract::Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2017.0061
更新日期:2018-06-01 00:00:00
abstract::Since the first ascent of Mont Blanc by Jacques Balmat and Dr. Michel-Gabriel Paccard in 1786, numerous scientific events have taken place on the highest peak of Europe. Horace Benédict de Saussure, since his first ascent in 1787, made numerous observations on barometric pressure, temperature, geology, and mountain si...
journal_title:High altitude medicine & biology
pub_type: 历史文章,杂志文章
doi:10.1089/152702901750067936
更新日期:2001-04-01 00:00:00
abstract::West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0152
更新日期:2017-06-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common and disabling condition that occurs in healthy individuals ascending to high altitude. Based on the ability of iron to influence cellular oxygen sensing pathways, we hypothesized that iron supplementation would protect against AMS. To examine this hypothesis, 24 healthy sea-le...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2011.1005
更新日期:2011-10-01 00:00:00
abstract::Transient focal neurological deficits have been described in sojourners to high altitude. We present two cases of transient expressive aphasia in well-acclimatized high altitude climbers. We speculate that this type of transient focal neurological impairment may represent migraine aura, and we discuss other reports of...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/15270290050144208
更新日期:2000-10-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common condition in individuals who travel to altitudes over 2000 m. While AMS is an important public health problem, no measurements can reliably support or predict the diagnosis with any degree of confidence. We therefore set out to study whether pulse oximetry data are associated ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.341
更新日期:2004-10-01 00:00:00
abstract::The purpose of this study was to compare three commonly used scoring systems of acute mountain sickness (AMS)-the 5-item Lake Louise Self-report (LLS), the 11-item abridged version of the Environmental Symptoms Questionnaire (ESQ-III), and a 100 mm visual analog scale (VAS)-on climbers (N=63; 34.6±9.9 years) making a ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1030
更新日期:2012-12-01 00:00:00
abstract::In hypobaric hypoxia (HH) at high altitude, the immune responses are changed probably due to oxidative stress-induced production of free radicals and nonradicals. Vitamin E is an antioxidant and protects the cells from oxidative damage. The present study was carried out to study the antioxidant role of vitamin E on th...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0045
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Abnormally high pulmonary artery pressure (PAP) in hypoxia due to exaggerated hypoxic pulmonary vasoconstriction (HPV) is a key factor for development of high-altitude pulmonary edema (HAPE). It was shown that about 10% of a healthy Caucasian population has an exaggerated HPV that is comparable to the respon...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1117
更新日期:2015-03-01 00:00:00
abstract:AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1091
更新日期:2013-12-01 00:00:00
abstract::High altitude training is a widely used strategy for improving aerobic exercise performance. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements have been reported to improve exercise performance. However, it is not clear whether the provision of R and C during high altitude training could further enhan...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2013.1114
更新日期:2014-09-01 00:00:00
abstract::Hypoxemia is a major life-threatening complication of childhood pneumonia. The threshold points for hypoxemia vary with altitude. However, few published data describe that normal range of variation. The purpose of this study was to establish reference values of normal mean Sao(2) levels and an approximate cutoff point...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1094
更新日期:2011-04-01 00:00:00
abstract::Survey of on-site treatment of patients in mountain areas of 14 countries in Europe and North America (nonresponder rate 33%) to compare emergency medical services. Around 37,535 ground rescuers and 747 helicopters are ready for evacuation of casualties and patients in mountain areas. And 1316 physicians and 50,967 pa...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2005.6.226
更新日期:2005-10-01 00:00:00
abstract::The effects of exposure to acute and chronic high altitude hypoxia on the activity and expression of CYP2E1 and CYP3A1 were examined in rats. Rats were divided into low altitude (LA, 400 m), acute moderate altitude hypoxia (AMH, 2800 m), chronic moderate altitude hypoxia (CMH, 2800 m), acute high altitude hypoxia (AHH...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1026
更新日期:2014-12-01 00:00:00
abstract::The present study reports the possible role of oxidative stress and inflammation (role of nuclear factor, NFkB) in hypoxia-induced transvascular leakage in brain of rats. The rats were exposed to a simulated altitude of 25,000 ft for different durations: 0, 3, 6, 12, 24, and 48h. Brain water content, transvascular lea...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1057
更新日期:2010-10-01 00:00:00
abstract::Over the past 40 years, in an attempt to reduce the morbidity and mortality of altitude illness, a number of volunteer-run, seasonal aid posts have been established at mountain ranges across the world. As each aid post is designed for the local population and tourists at hand, the range of problems seen and services o...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0052
更新日期:2019-12-01 00:00:00
abstract::The planning and execution of avalanche rescue missions to search for totally buried avalanche victims are mostly based on personal experience and preference, as evidence-based information from literature is almost completely missing. Hence, the aim of this study was to identify major factors determining the survival ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1061
更新日期:2008-10-01 00:00:00