Abstract:
:Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum of cancer types. In fact, the majority of the physiological adaptive processes at HA occurring in response to hypoxia might be the driving force for reduced cancer mortality at HA. In this review, we summarize epidemiological and animal studies that compare cancer incidence and cancer mortality between HA and low altitude or between hypoxia and normoxia, respectively. We discuss the potential role of oxygen-independent and oxygen-dependent mechanisms that might contribute to reduced cancer mortality at HA. Reactive oxygen species and their detoxification as well as the hypoxia-inducible factors are especially promising targets and may be related to why cancer mortality is reduced at HA. In addition, we briefly discuss two aspects with a proven impact on tumorigenesis, namely the immune system and tumor surveillance as well as HA-induced metabolic changes. Further animal and clinical studies are clearly needed to explain why cancer mortality is reduced at HA and to decide whether HA or hypoxia-based therapeutic approaches could be implemented for cancer treatment. However, exposure to HA activates multiple adaptive mechanisms (oxygen independent and oxygen dependent) sharing common pathways as well as activating counteracting pathways, which complicate the identification of specific HA-induced mechanisms of tumor suppression.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Thiersch M,Swenson ERdoi
10.1089/ham.2017.0061subject
Has Abstractpub_date
2018-06-01 00:00:00pages
116-123issue
2eissn
1527-0297issn
1557-8682journal_volume
19pub_type
杂志文章,评审abstract::Frequency of therapeutic beta-blocker use in elderly mountaineers is unknown. Therefore, the aim of this field study was to measure the regular beta-blocker intake in elderly persons visiting moderate altitudes. In a subset of mountaineers on beta-blockers, exercise response at two different altitude levels was compar...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702903322616227
更新日期:2003-01-01 00:00:00
abstract::Hypoxemia is a major life-threatening complication of childhood pneumonia. The threshold points for hypoxemia vary with altitude. However, few published data describe that normal range of variation. The purpose of this study was to establish reference values of normal mean Sao(2) levels and an approximate cutoff point...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1094
更新日期:2011-04-01 00:00:00
abstract::To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2005.6.158
更新日期:2005-07-01 00:00:00
abstract::Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focu...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2019.0049
更新日期:2019-12-01 00:00:00
abstract::Otero, Liliana, Patricia Hidalgo, Rafael González, and Carlos A. Morillo. Association of cardiovascular disease and sleep apnea at different altitudes. High Alt Med Biol. 17:336-341, 2016.-We evaluated the prevalence of sleep apnea (SA) in patients with cardiovascular disease (CVD) at different altitudes. A total of 3...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0027
更新日期:2016-12-01 00:00:00
abstract::Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature c...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2013.1016
更新日期:2013-06-01 00:00:00
abstract::The present study reports the possible role of oxidative stress and inflammation (role of nuclear factor, NFkB) in hypoxia-induced transvascular leakage in brain of rats. The rats were exposed to a simulated altitude of 25,000 ft for different durations: 0, 3, 6, 12, 24, and 48h. Brain water content, transvascular lea...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1057
更新日期:2010-10-01 00:00:00
abstract::Given the high inter-individual variability in the sensitivity to high altitude, we hypothesize the presence of underlying genetic factors. The aim of this study was to construct a genetic predisposition score based on previously identified high-altitude gene variants to explain the inter-individual variation in the r...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1083
更新日期:2015-03-01 00:00:00
abstract::The purpose of high altitude continuing medical education is to adapt knowledge and skills for practical application on the plateau. Most trainees have experience with academic education and grassroots work experience on the plateau, so they want knowledge about new advances in the pathogenesis, diagnosis, and treatme...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1093
更新日期:2013-06-01 00:00:00
abstract:: Background: Sex-based differences in metabolism and morphological characteristics may result in unique exercise responses during periods of limited oxygen availability. Purpose: To evaluate the effects of moderate normobaric hy...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0061
更新日期:2020-03-01 00:00:00
abstract::Acute altitude exposure may lead to acute mountain sickness (AMS). Increased awareness of altitude-related health hazards in trekkers may accompany a decrease in AMS prevalence. We compared awareness and AMS prevalence in trekkers in two cohorts on an altitude trek up to 5400 m and assessed risk factors for AMS by rep...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.410
更新日期:2004-01-01 00:00:00
abstract::Álvarez-Herms, Jesús, Sonia Julià-Sánchez, Hannes Gatterer, Francisco Corbi, Gines Viscor, and Martin Burtscher. Effects of a single power strength training session on heart rate variability when performed at different simulated altitudes. High Alt Med Biol. 21:292-296, 2020. Background: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0014
更新日期:2020-09-01 00:00:00
abstract::We conducted a survey of equipment in medical backpacks for mountain rescuers and mountain emergency physicians. The aim was to investigate whether there are standards for medical equipment in mountain rescue organizations associated with the International Commission for Mountain Emergency Medicine (ICAR MEDCOM). A qu...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2010.1048
更新日期:2011-01-01 00:00:00
abstract::The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/152702903322022785
更新日期:2003-07-01 00:00:00
abstract::Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru. High Alt Med Biol...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1086
更新日期:2015-03-01 00:00:00
abstract::Although thousands of people ascend 4205 m to visit the summit of Mauna Kea each year, there has been no information on the rate of altitude illness triggered by such visits. Two surveys were used: one for tourists driving up to the summit and the other for summit astronomy workers staying at lodging facilities at int...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.8307
更新日期:2007-10-01 00:00:00
abstract::Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/1527029041352081
更新日期:2004-07-01 00:00:00
abstract:: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0128
更新日期:2019-06-01 00:00:00
abstract::Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2018.0121
更新日期:2019-06-01 00:00:00
abstract::Chronic hypoxia has a profound effect on uterine artery adaptation to pregnancy. The present studies tested the hypothesis that pregnant kinase C (PKC) differentially regulates alpha(1)-adrenoceptor-mediated contractions and Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to h...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1076
更新日期:2010-07-01 00:00:00
abstract::Over the past 40 years, in an attempt to reduce the morbidity and mortality of altitude illness, a number of volunteer-run, seasonal aid posts have been established at mountain ranges across the world. As each aid post is designed for the local population and tourists at hand, the range of problems seen and services o...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0052
更新日期:2019-12-01 00:00:00
abstract::We describe the case of a 38-year-old man who presented with bilateral retinal detachments following a trek in Tibet during which time he took acetazolamide for prophylaxis of acute mountain sickness (AMS). This is the first time that retinal detachment has been described following a sojourn to high altitude. Acetazol...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1026
更新日期:2007-01-01 00:00:00
abstract::Wagner, Dale R., Skyler Saunders, Brady Robertson, and John E. Davis. Normobaric hypoxia effects on balance measured by computerized dynamic posturography. High Alt Med Biol. 17:222-227, 2016.-Background/Aim: Equilibrium was measured by computerized dynamic posturography at varying levels of normobaric hypoxia before ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0040
更新日期:2016-09-01 00:00:00
abstract::West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0152
更新日期:2017-06-01 00:00:00
abstract::The present study compares the changes in ventilation in response to sustained hypobaric hypoxia and acute normobaric hypoxia between subjects susceptible to high altitude pulmonary edema (HAPE-S) and control subjects (C-S). Seven HAPE-S and five C-S were exposed to simulated high altitude of 4000 m for 23 h in a hypo...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702902320604241
更新日期:2002-10-01 00:00:00
abstract::High altitude (HA) presents inhospitable environmental conditions that adversely affects human physiology and metabolism. Changes in physiological functions are reported during high altitude exposure, but the changes vary with physical state, culture habits, geographical locations, and genetic variation of individual....
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1071
更新日期:2013-03-01 00:00:00
abstract::Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-re...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0008
更新日期:2018-12-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common condition in individuals who travel to altitudes over 2000 m. While AMS is an important public health problem, no measurements can reliably support or predict the diagnosis with any degree of confidence. We therefore set out to study whether pulse oximetry data are associated ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.341
更新日期:2004-10-01 00:00:00
abstract::Transient focal neurological deficits have been described in sojourners to high altitude. We present two cases of transient expressive aphasia in well-acclimatized high altitude climbers. We speculate that this type of transient focal neurological impairment may represent migraine aura, and we discuss other reports of...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/15270290050144208
更新日期:2000-10-01 00:00:00
abstract::Hamm, Wolfgang, Sari Kassem, Lukas von Stülpnagel, Florian Maier, Mathias Klemm, Dominik Schüttler, Felix Grabher, Ludwig T. Weckbach, Bruno C. Huber, Axel Bauer, Konstantinos D. Rizas, and Stefan Brunner. Deceleration capacity and periodic repolarization dynamics as predictors of acute mountain sickness. High Alt Med...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0131
更新日期:2020-12-01 00:00:00