Abstract:
:We describe the case of a 38-year-old man who presented with bilateral retinal detachments following a trek in Tibet during which time he took acetazolamide for prophylaxis of acute mountain sickness (AMS). This is the first time that retinal detachment has been described following a sojourn to high altitude. Acetazolamide has not been previously associated with retinal detachment when used for prophylaxis of AMS or indeed during its many ophthalmic applications. The patient made a good recovery following surgery, and we speculate that, although this could be coincidental and the patient did have risk factors for retinal detachment, the possibility of a causal link to high altitude should at least be entertained. We hypothesize that vitreous dehydration may have caused vitreoretinal traction and that hypobaric hypoxia may have changed the dynamic relationship between vitreous, retina, retinal pigment epithelium (RPE) and choroid, causing preexisting retinal holes to open, allowing subretinal fluid to accumulate and detach the retina.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Morris DS,Severn PS,Smith J,Somner JE,Stannard KP,Cottrell DGdoi
10.1089/ham.2007.1026subject
Has Abstractpub_date
2007-01-01 00:00:00pages
337-9issue
4eissn
1527-0297issn
1557-8682journal_volume
8pub_type
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