Abstract：
: Background: The physiological effects of hypoxia may be influenced by how hypoxia is achieved. The purpose of this study was to determine the effects of recovery in hypobaric hypoxia (HH), normobaric hypoxia (NH), and normobaric normoxia (NN) after endurance exercise on gene expression related to mitochondrial biogenesis, myogenesis, and proteolysis. Methods: Fifteen recreationally trained subjects each cycled for 1 hour before recovering for 4 hours in NN (laboratory atmospheric conditions, 975 m), HH (depressurized to simulate 4420 m), and NH (fraction of O2 reduced to simulate 4420 m). Muscle biopsy samples were obtained before exercise and after 4 hours of recovery. Results: Blood oxygenation (SpO2) was lower in HH (76.02 ± 0.58%) than NH (79.45 ± 0.56, p < 0.001), which were both lower than in NN (96.3 ± 0.17, p < 0.001). Heart rate was higher in HH (82 ± 2 bpm) than NH (77 ± 1 bpm, p < 0.001), which were both higher than in NN (67 ± 1 bpm, p < 0.001). Mitochondrial transcription factor A (TFAM) mRNA was lower after NN than HH (p = 0.034) or NH (p = 0.005), but was not different between HH and NH (p = 0.460). Myostatin (MSTN) mRNA decreased from pre- to postexercise (p < 0.001) in all conditions and was lower in HH compared with NH (p = 0.035) and NN (p = 0.017). No other differences were noted in genes related to mitochondrial biogenesis, myogenesis, or proteolysis (p > 0.05). Conclusion: TFAM mRNA is lower with hypoxia exposure, but effected by the type of hypoxia. MSTN gene expression is lower after exposure to HH than NH or NN. These data support previous work and caution the translation of NH data obtained in a NH environment to a HH environment.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Ross CI,Shute RJ,Ruby BC,Slivka DRdoi
10.1089/ham.2018.0147subject
Has Abstractpub_date
2019-06-01 00:00:00pages
141-149issue
2eissn
1527-0297issn
1557-8682journal_volume
20pub_type
杂志文章abstract：:Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,meta分析,评审
doi：10.1089/ham.2011.1084
更新日期：2012-06-01 00:00:00
abstract：:Hamm, Wolfgang, Sari Kassem, Lukas von Stülpnagel, Florian Maier, Mathias Klemm, Dominik Schüttler, Felix Grabher, Ludwig T. Weckbach, Bruno C. Huber, Axel Bauer, Konstantinos D. Rizas, and Stefan Brunner. Deceleration capacity and periodic repolarization dynamics as predictors of acute mountain sickness. High Alt Med...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2020.0131
更新日期：2020-12-01 00:00:00
abstract：:Luks, Andrew M. Should travelers with hypertension adjust their medications when traveling to high altitude? High Alt. Med. Biol. 10:11-15, 2009.-When advising travelers to high altitude, clinicians should consider how their patient's underlying medical conditions may be affected by the high altitude and whether chang...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2008.1076
更新日期：2009-04-01 00:00:00
abstract：:Appointing physiological function to specific genetic determinants requires a systems physiologist to consider ways of assessing precise phenotypic mechanisms. The integration of ventilation, metabolism and thermoregulation, for example, is very complex and may differ among small and large mammalian species. This chal...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702901750265297
更新日期：2001-07-01 00:00:00
abstract：:West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0152
更新日期：2017-06-01 00:00:00
abstract：:The aim was to establish scientifically supported recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue, which can be applied by physicians and nonphysicians. A literature search was performed; the results and recommendations were discussed among the authors, and finally approved by...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2011.1096
更新日期：2012-09-01 00:00:00
abstract：:In hypobaric hypoxia (HH) at high altitude, the immune responses are changed probably due to oxidative stress-induced production of free radicals and nonradicals. Vitamin E is an antioxidant and protects the cells from oxidative damage. The present study was carried out to study the antioxidant role of vitamin E on th...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0045
更新日期：2019-03-01 00:00:00
abstract：:The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2007.1053
更新日期：2008-04-01 00:00:00
abstract：: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0128
更新日期：2019-06-01 00:00:00
abstract：:The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702903322022785
更新日期：2003-07-01 00:00:00
abstract：:Wang, Xing-Min, Hui Liu, Jian-Yu Li, Jin-Xia Wei, Xia Li, Yong-Liang Zhang, Ling-Zhi Li, and Xi-Zheng Zhang. Rosamultin attenuates acute hypobaric hypoxia-induced bone injuries by regulation of sclerostin and its downstream signals. High Alt Med Biol. 21:273-286, 2020. Background: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0113
更新日期：2020-09-01 00:00:00
abstract：:Frequency of therapeutic beta-blocker use in elderly mountaineers is unknown. Therefore, the aim of this field study was to measure the regular beta-blocker intake in elderly persons visiting moderate altitudes. In a subset of mountaineers on beta-blockers, exercise response at two different altitude levels was compar...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702903322616227
更新日期：2003-01-01 00:00:00
abstract：:Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2017.0061
更新日期：2018-06-01 00:00:00
abstract：: Background: Sex-based differences in metabolism and morphological characteristics may result in unique exercise responses during periods of limited oxygen availability. Purpose: To evaluate the effects of moderate normobaric hy...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0061
更新日期：2020-03-01 00:00:00
abstract：:Hypoxemia is a major life-threatening complication of childhood pneumonia. The threshold points for hypoxemia vary with altitude. However, few published data describe that normal range of variation. The purpose of this study was to establish reference values of normal mean Sao(2) levels and an approximate cutoff point...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2009.1094
更新日期：2011-04-01 00:00:00
abstract：:We conducted a survey of equipment in medical backpacks for mountain rescuers and mountain emergency physicians. The aim was to investigate whether there are standards for medical equipment in mountain rescue organizations associated with the International Commission for Mountain Emergency Medicine (ICAR MEDCOM). A qu...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2010.1048
更新日期：2011-01-01 00:00:00
abstract：:Álvarez-Herms, Jesús, Sonia Julià-Sánchez, Hannes Gatterer, Francisco Corbi, Gines Viscor, and Martin Burtscher. Effects of a single power strength training session on heart rate variability when performed at different simulated altitudes. High Alt Med Biol. 21:292-296, 2020. Background: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2020.0014
更新日期：2020-09-01 00:00:00
abstract：:To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2005.6.158
更新日期：2005-07-01 00:00:00
abstract：:Given the high inter-individual variability in the sensitivity to high altitude, we hypothesize the presence of underlying genetic factors. The aim of this study was to construct a genetic predisposition score based on previously identified high-altitude gene variants to explain the inter-individual variation in the r...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1083
更新日期：2015-03-01 00:00:00
abstract：:Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the w...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2008.1094
更新日期：2009-10-01 00:00:00
abstract：:A 31-year-old man suffered diplopia and ataxia on two occasions when he ascended from sea level to 4,000 m. Evaluation revealed a moderate-sized subarachnoid cyst in the left frontal region, which did not communicate with the cerebral ventricles. The cyst might have acted as a space-occupying lesion, and caused sympto...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/15270290050502417
更新日期：2000-01-01 00:00:00
abstract：AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1091
更新日期：2013-12-01 00:00:00
abstract：:Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0121
更新日期：2019-06-01 00:00:00
abstract：:The male reproductive functions of the members of the Masherbrum (7821 m) Expedition in 1999 were examined via semen analyses and endocrine tests. Specimens were collected from three subjects who had stayed above 5100 m for 21 to 24 days and above 6700 m for 4 to 5 days before departure and 1 month, 3 months, and 2 yr...
journal_title：High altitude medicine & biology
pub_type： 临床试验,杂志文章
doi：10.1089/152702903769192304
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Abnormally high pulmonary artery pressure (PAP) in hypoxia due to exaggerated hypoxic pulmonary vasoconstriction (HPV) is a key factor for development of high-altitude pulmonary edema (HAPE). It was shown that about 10% of a healthy Caucasian population has an exaggerated HPV that is comparable to the respon...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1117
更新日期：2015-03-01 00:00:00
abstract：:The present study evaluated the effect of a sleep high-train low regimen on the finger cold-induced vasodilation (CIVD) response. Seventeen healthy males were assigned to either a control (CON; n=9) or experimental (EXP; n=8) group. Each group participated in a 28-day aerobic training program of daily 1-h exercise (50...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2011.1044
更新日期：2012-03-01 00:00:00
abstract：:Exposure to hypoxic environments is associated with decreased arterial oxygen saturation and increased pulmonary artery pressures. Ischemic preconditioning of an extremity (IPC) is a procedure that stimulates vasoactive and inflammatory pathways that protect remote organ systems from ongoing or future ischemic injury....
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2013.1137
更新日期：2014-06-01 00:00:00
abstract：:Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort s...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2017.0001
更新日期：2017-09-01 00:00:00
abstract：:High altitude training is a widely used strategy for improving aerobic exercise performance. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements have been reported to improve exercise performance. However, it is not clear whether the provision of R and C during high altitude training could further enhan...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2013.1114
更新日期：2014-09-01 00:00:00
abstract：:The purpose of this study was to compare three commonly used scoring systems of acute mountain sickness (AMS)-the 5-item Lake Louise Self-report (LLS), the 11-item abridged version of the Environmental Symptoms Questionnaire (ESQ-III), and a 100 mm visual analog scale (VAS)-on climbers (N=63; 34.6±9.9 years) making a ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1030
更新日期：2012-12-01 00:00:00
