Abstract：
:Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the world. This is a case report of a climber who suffered an episode of HAPE partway up Mount Everest. He was determined to complete his summit attempt that same climbing season, which would involve a return to extreme altitude less than 3 weeks following recovery. Based on experimental evidence suggesting that sildenafil, salmeterol, and acetazolamide may have therapeutic value for both the prevention and treatment of HAPE, he used these medications for secondary prevention. He was able to successfully reach the summit of Mount Everest and return to base camp without any evidence of recurrence of pulmonary edema. This provides clinical evidence that medication can be used to increase the safety margin for HAPE-susceptible individuals traveling to extremely high altitudes.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Dunin-Bell O,Boyle Sdoi
10.1089/ham.2008.1094subject
Has Abstractpub_date
2009-10-01 00:00:00pages
293-6issue
3eissn
1527-0297issn
1557-8682journal_volume
10pub_type
杂志文章abstract：:The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sild...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2007.1058
更新日期：2007-07-01 00:00:00
abstract：:The present study compares the changes in ventilation in response to sustained hypobaric hypoxia and acute normobaric hypoxia between subjects susceptible to high altitude pulmonary edema (HAPE-S) and control subjects (C-S). Seven HAPE-S and five C-S were exposed to simulated high altitude of 4000 m for 23 h in a hypo...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702902320604241
更新日期：2002-10-01 00:00:00
abstract：:The effects of exposure to acute and chronic high altitude hypoxia on the activity and expression of CYP2E1 and CYP3A1 were examined in rats. Rats were divided into low altitude (LA, 400 m), acute moderate altitude hypoxia (AMH, 2800 m), chronic moderate altitude hypoxia (CMH, 2800 m), acute high altitude hypoxia (AHH...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1026
更新日期：2014-12-01 00:00:00
abstract：:Exposure to hypoxic environments is associated with decreased arterial oxygen saturation and increased pulmonary artery pressures. Ischemic preconditioning of an extremity (IPC) is a procedure that stimulates vasoactive and inflammatory pathways that protect remote organ systems from ongoing or future ischemic injury....
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2013.1137
更新日期：2014-06-01 00:00:00
abstract：:Gou, Qiling, Rufeng Shi, Xin Zhang, Qingtao Meng, Xinran Li, Xi Rong, Zhabu Gawa, Nage Zhuoma, and Xiaoping Chen. The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan Province, China. High Alt Med Biol. 21:327-335, 2020. Background: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2020.0022
更新日期：2020-12-01 00:00:00
abstract：: Aims: Psychotic symptoms during exposure to high altitude (HA) have been linked to accidents or near accidents on the mountains. It is thus of great importance to directly identify psychotic symptoms in individuals who are exposed to HA quickly and reliably on the mountain...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0009
更新日期：2019-12-01 00:00:00
abstract：:Otero, Liliana, Patricia Hidalgo, Rafael González, and Carlos A. Morillo. Association of cardiovascular disease and sleep apnea at different altitudes. High Alt Med Biol. 17:336-341, 2016.-We evaluated the prevalence of sleep apnea (SA) in patients with cardiovascular disease (CVD) at different altitudes. A total of 3...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0027
更新日期：2016-12-01 00:00:00
abstract：:High altitude (HA) presents inhospitable environmental conditions that adversely affects human physiology and metabolism. Changes in physiological functions are reported during high altitude exposure, but the changes vary with physical state, culture habits, geographical locations, and genetic variation of individual....
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1071
更新日期：2013-03-01 00:00:00
abstract：:High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied. To fulfill these objectives...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0031
更新日期：2019-03-01 00:00:00
abstract：:Given the high inter-individual variability in the sensitivity to high altitude, we hypothesize the presence of underlying genetic factors. The aim of this study was to construct a genetic predisposition score based on previously identified high-altitude gene variants to explain the inter-individual variation in the r...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1083
更新日期：2015-03-01 00:00:00
abstract：:Acute altitude exposure may lead to acute mountain sickness (AMS). Increased awareness of altitude-related health hazards in trekkers may accompany a decrease in AMS prevalence. We compared awareness and AMS prevalence in trekkers in two cohorts on an altitude trek up to 5400 m and assessed risk factors for AMS by rep...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2004.5.410
更新日期：2004-01-01 00:00:00
abstract：:We describe the case of a 38-year-old man who presented with bilateral retinal detachments following a trek in Tibet during which time he took acetazolamide for prophylaxis of acute mountain sickness (AMS). This is the first time that retinal detachment has been described following a sojourn to high altitude. Acetazol...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2007.1026
更新日期：2007-01-01 00:00:00
abstract：:The aims of the present study were to measure the satiety neuropeptide cholecystokinin (CCK) in humans at terrestrial high altitude to investigate its possible role in the pathophysiology of anorexia, cachexia, and acute mountain sickness (AMS). Nineteen male mountaineers aged 38 +/- 12 years participated in a 20 +/- ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702900320649
更新日期：2000-04-01 00:00:00
abstract：:Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-re...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0008
更新日期：2018-12-01 00:00:00
abstract：UNLABELLED:Chronic hypoxia increases dependence on glucose in men and increases insulin sensitivity in men and women. Cyclic Variations in Altitude Conditioning (CVAC) is a novel technology that provides exposure to rapidly fluctuating cyclic hypobaric hypoxia (CHH). PURPOSE:To test the hypothesis that markers of gluc...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1057
更新日期：2013-09-01 00:00:00
abstract：: Background: Platelets are the key factor in primary hemostasis. It has been shown that chronic altitude exposure increases platelets' aggregability. Nevertheless, data about acute effects and the underlying mechanisms are sparse. Methods: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0112
更新日期：2019-09-01 00:00:00
abstract：:Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0121
更新日期：2019-06-01 00:00:00
abstract：:With the increasing popularity of adventure travel and mountain activities, it is likely that many high altitude travelers will have underlying medical problems and approach clinicians for advice about ensuring a safe sojourn. Patients with underlying pulmonary hypertension are one group who warrants significant conce...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2009.10306
更新日期：2009-10-01 00:00:00
abstract：:The development of mining activities in North Chile involves a great number of workers intermittently exposed to high altitude for a long period of time (chronic intermittent hypoxia, CIH). A 2(1/2)-year prospective study aimed to characterize this model of exposure to CIH and to know whether this condition may progre...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/15270290260131894
更新日期：2002-07-01 00:00:00
abstract：:The Swiss expedition to Everest (altitude 8,848 m) in the spring of 1952 very nearly attained the summit with two of the climbers reaching 8,595 m. This would have been the first ascent of Everest. One main reason for failure was the inadequate oxygen equipment which was modified from sets designed for mine rescue usi...
journal_title：High altitude medicine & biology
pub_type： 历史文章,杂志文章
doi：10.1089/152702903321488960
更新日期：2003-04-01 00:00:00
abstract：AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1091
更新日期：2013-12-01 00:00:00
abstract：:Over the past 40 years, in an attempt to reduce the morbidity and mortality of altitude illness, a number of volunteer-run, seasonal aid posts have been established at mountain ranges across the world. As each aid post is designed for the local population and tourists at hand, the range of problems seen and services o...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0052
更新日期：2019-12-01 00:00:00
abstract：:A variety of neurological disorders other than high altitude cerebral edema have been described at high altitude. This report documents isolated facial and hypoglossal nerve palsies that occurred in two travellers at high altitude in the Nepal Himalaya. The possible pathophysiological mechanisms of these neurological ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702901750265396
更新日期：2001-07-01 00:00:00
abstract：:Neurological disturbances may be present at high altitude independently of high altitude cerebral edema. We report here the case of a patient who experienced for the first time generalized seizures after spending a night at an altitude of 5200 m, with no preceding symptoms of acute mountain sickness. An initial CT sca...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2006.7.81
更新日期：2006-04-01 00:00:00
abstract：:Ha, Hoehun. Geographic variation in mentally unhealthy days: air pollution and altitude perspectives. High Alt Med Biol. 18:258-266, 2017. BACKGROUND:Mental health incorporates our emotional, psychological, and social well-being and it is critical at each phase of life, from youth and preadulthood through adulthood. ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0137
更新日期：2017-09-01 00:00:00
abstract：:The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702903322022785
更新日期：2003-07-01 00:00:00
abstract：:A 36-year-old woman with no medical history participated in a trekking in Ladakh up to 5300 m of altitude. She was well acclimatized and presented no previous sign of acute mountain sickness, high altitude pulmonary edema or high altitude cerebral edema. After an intense effort to catch up with her group, she became b...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0100
更新日期：2020-03-01 00:00:00
abstract：:Appointing physiological function to specific genetic determinants requires a systems physiologist to consider ways of assessing precise phenotypic mechanisms. The integration of ventilation, metabolism and thermoregulation, for example, is very complex and may differ among small and large mammalian species. This chal...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702901750265297
更新日期：2001-07-01 00:00:00
abstract：:Alpinist and scientist George Ingle Finch was invited on the 1921 British Mount Everest Reconnaissance, but events conspired to keep him away from Everest until the 1922 British expedition to the mountain. Very little is known in the English-speaking world about the 1925 German language book Der Kampf um den Everest, ...
journal_title：High altitude medicine & biology
pub_type： 传,历史文章,杂志文章
doi：10.1089/ham.2006.1034
更新日期：2007-04-01 00:00:00
abstract：:Van Iterson, Erik H., Eric M. Snyder, and Bruce D. Johnson. The influence of 17 hours of normobaric hypoxia on parallel adjustments in exhaled nitric oxide and airway function in lowland healthy adults. High Alt Med Biol. 18:1-10, 2017.-Currently, there is a disparate understanding of the role that normobaric hypoxia ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0086
更新日期：2017-03-01 00:00:00
