Abstract:
:High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied. To fulfill these objectives, Sprague-Dawley (SD) rats were divided into five groups namely Control and HH exposed (1, 3, 7, and 14 days). All groups except control were exposed to 7620 m of HH in an animal decompression chamber for the respective time intervals. Different degrees of intestinal mucosal damage in terms of increased mucosal permeability and disruption of intestinal villi were observed for different time intervals. HH exposure also upregulated secretory immunoglobulin A (sIgA) and proinflammatory cytokines in GI lavage along with proinflammatory markers such as toll-like receptor 4 (TLR4) and inducible nitric oxide synthase (iNOS). HH exposure of rats for 7 days significantly increased interleukin-17 (IL-17) and natural killer (NK) cell and dendritic cell populations compared with unexposed control rats. However, the number of naive T cells was significantly decreased in Peyer's patches. Our results connect HH to GI immune axis and highlight Th17 cells and proinflammatory molecules as potential therapeutic targets to counteract HH-induced GI dysfunction.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Khanna K,Mishra KP,Chanda S,Eslavath MR,Ganju L,Kumar B,Singh SBdoi
10.1089/ham.2018.0031subject
Has Abstractpub_date
2019-03-01 00:00:00pages
35-44issue
1eissn
1527-0297issn
1557-8682journal_volume
20pub_type
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journal_title:High altitude medicine & biology
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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