Abstract：
:The development of mining activities in North Chile involves a great number of workers intermittently exposed to high altitude for a long period of time (chronic intermittent hypoxia, CIH). A 2(1/2)-year prospective study aimed to characterize this model of exposure to CIH and to know whether this condition may progressively lead to a chronic pattern. Twenty-nine miners, aged 25 +/- 5 yr, working 7 days at HA (3800 to 4600 m) and resting 7 days at sea level (SL) were studied. Subjects underwent a physical examination, EKG, hematological status, maximal exercise test, ventilatory and cardiac response to hypoxia (F(iO2) = 0.114) at rest and exercise, pulmonary vascular response to hypoxia by echocardiography, and 24-h monitoring of EKG and arterial pressure. Basal evaluations were performed at SL before the first exposure to hypoxia. HA measurements were daily AMS score, sleep status, and 24-h monitoring of EKG and arterial pressure. All these measurements were repeated after a mean period of 12, 19, and 31 months. Hematocrit increased but reached values lower than those observed in chronic permanent exposure. Systemic and pulmonary arterial pressures measured at SL did not change, but were higher in hypoxia. Right ventricle showed a slight dilatation. Exercise performance at SL declined with exposure to CIH to reach a 12.3% decrease after 31 months of CIH, associated with a 6.8% decrease in maximal heart rate. Signs of ventilatory acclimatization were observed after 12 months. Symptoms of AMS and sleep disturbances were still seen on the first 2 days at HA, whatever the time of exposure to CIH. In conclusion, CIH induced a clear acclimatization process. Subjects did not reach a health status comparable to that seen in permanent residents at HA and remained at risk of acute altitude-induced illnesses.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Richalet JP,Donoso MV,Jiménez D,Antezana AM,Hudson C,Cortès G,Osorio J,Leòn Adoi
10.1089/15270290260131894keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
159-66issue
2eissn
1527-0297issn
1557-8682journal_volume
3pub_type
杂志文章abstract：:With the increasing popularity of adventure travel and mountain activities, it is likely that many high altitude travelers will have underlying medical problems and approach clinicians for advice about ensuring a safe sojourn. Patients with underlying pulmonary hypertension are one group who warrants significant conce...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2009.10306
更新日期：2009-10-01 00:00:00
abstract：:The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2007.1053
更新日期：2008-04-01 00:00:00
abstract：:Exposure to hypoxic environments is associated with decreased arterial oxygen saturation and increased pulmonary artery pressures. Ischemic preconditioning of an extremity (IPC) is a procedure that stimulates vasoactive and inflammatory pathways that protect remote organ systems from ongoing or future ischemic injury....
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2013.1137
更新日期：2014-06-01 00:00:00
abstract：:Over the past 40 years, in an attempt to reduce the morbidity and mortality of altitude illness, a number of volunteer-run, seasonal aid posts have been established at mountain ranges across the world. As each aid post is designed for the local population and tourists at hand, the range of problems seen and services o...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0052
更新日期：2019-12-01 00:00:00
abstract：:The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702903322022785
更新日期：2003-07-01 00:00:00
abstract：:Hamm, Wolfgang, Sari Kassem, Lukas von Stülpnagel, Florian Maier, Mathias Klemm, Dominik Schüttler, Felix Grabher, Ludwig T. Weckbach, Bruno C. Huber, Axel Bauer, Konstantinos D. Rizas, and Stefan Brunner. Deceleration capacity and periodic repolarization dynamics as predictors of acute mountain sickness. High Alt Med...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2020.0131
更新日期：2020-12-01 00:00:00
abstract：:The number of avalanche accidents involving winter recreationists has notably increased in recent decades due to the increasing popularity of outdoor winter activities. The International Liaison Committee on Cardiopulmonary Resuscitation, the International Commission for Mountain Emergency Medicine (ICAR Medcom), and ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0036
更新日期：2018-12-01 00:00:00
abstract：:Shatylo, Valerii B., Tetiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, and Oleg V. Korkushko. Acute hypoxic test in patients with prediabetes. High Alt Med Biol. 17:101-107, 2016.-Prediabetes is a state of impaired carbohydrate metabolism when not all of the symptoms required to label a person as diabetic are pres...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2015.0117
更新日期：2016-06-01 00:00:00
abstract：:Since the first ascent of Mont Blanc by Jacques Balmat and Dr. Michel-Gabriel Paccard in 1786, numerous scientific events have taken place on the highest peak of Europe. Horace Benédict de Saussure, since his first ascent in 1787, made numerous observations on barometric pressure, temperature, geology, and mountain si...
journal_title：High altitude medicine & biology
pub_type： 历史文章,杂志文章
doi：10.1089/152702901750067936
更新日期：2001-04-01 00:00:00
abstract：:Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks ove...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2015.0030
更新日期：2015-06-01 00:00:00
abstract：:The male reproductive functions of the members of the Masherbrum (7821 m) Expedition in 1999 were examined via semen analyses and endocrine tests. Specimens were collected from three subjects who had stayed above 5100 m for 21 to 24 days and above 6700 m for 4 to 5 days before departure and 1 month, 3 months, and 2 yr...
journal_title：High altitude medicine & biology
pub_type： 临床试验,杂志文章
doi：10.1089/152702903769192304
更新日期：2003-10-01 00:00:00
abstract：:Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the w...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2008.1094
更新日期：2009-10-01 00:00:00
abstract：:Survey of on-site treatment of patients in mountain areas of 14 countries in Europe and North America (nonresponder rate 33%) to compare emergency medical services. Around 37,535 ground rescuers and 747 helicopters are ready for evacuation of casualties and patients in mountain areas. And 1316 physicians and 50,967 pa...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2005.6.226
更新日期：2005-10-01 00:00:00
abstract：: Background: Platelets are the key factor in primary hemostasis. It has been shown that chronic altitude exposure increases platelets' aggregability. Nevertheless, data about acute effects and the underlying mechanisms are sparse. Methods: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0112
更新日期：2019-09-01 00:00:00
abstract：:We describe the case of a 38-year-old man who presented with bilateral retinal detachments following a trek in Tibet during which time he took acetazolamide for prophylaxis of acute mountain sickness (AMS). This is the first time that retinal detachment has been described following a sojourn to high altitude. Acetazol...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2007.1026
更新日期：2007-01-01 00:00:00
abstract：:Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0121
更新日期：2019-06-01 00:00:00
abstract：:Li, Zongbin, Jun Guo, Chunwei Liu, Yajun Shi, Yang Li, Jinli Wang, Dandan Li, Jing Wang, and Yundai Chen. Compound Danshen Dripping Pill promotes adaptation to acute high-altitude exposure. High Alt Med Biol. 21:258-264, 2020. Background: In this study, we aimed to investi...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0126
更新日期：2020-09-01 00:00:00
abstract：:Hypoxemia is a major life-threatening complication of childhood pneumonia. The threshold points for hypoxemia vary with altitude. However, few published data describe that normal range of variation. The purpose of this study was to establish reference values of normal mean Sao(2) levels and an approximate cutoff point...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2009.1094
更新日期：2011-04-01 00:00:00
abstract：:Transient focal neurological deficits have been described in sojourners to high altitude. We present two cases of transient expressive aphasia in well-acclimatized high altitude climbers. We speculate that this type of transient focal neurological impairment may represent migraine aura, and we discuss other reports of...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/15270290050144208
更新日期：2000-10-01 00:00:00
abstract：:West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0152
更新日期：2017-06-01 00:00:00
abstract：:Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2017.0061
更新日期：2018-06-01 00:00:00
abstract：:Allergies and adverse reactions to sulfonamide medications are quite common. Two distinct categories of drugs are classified as sulfonamides: antibiotics and nonantibiotics. The two groups differ in their chemical structure, use, and the rate at which adverse reactions occur. Cross-reactivity between the two groups ha...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2010.1051
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Abnormally high pulmonary artery pressure (PAP) in hypoxia due to exaggerated hypoxic pulmonary vasoconstriction (HPV) is a key factor for development of high-altitude pulmonary edema (HAPE). It was shown that about 10% of a healthy Caucasian population has an exaggerated HPV that is comparable to the respon...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1117
更新日期：2015-03-01 00:00:00
abstract：:Appointing physiological function to specific genetic determinants requires a systems physiologist to consider ways of assessing precise phenotypic mechanisms. The integration of ventilation, metabolism and thermoregulation, for example, is very complex and may differ among small and large mammalian species. This chal...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702901750265297
更新日期：2001-07-01 00:00:00
abstract：:Alarcón-Yaquetto, Dulce E., Lidia Caballero, and Gustavo F. Gonzales. Association between plasma N-acylethanolamides and high hemoglobin concentration in Southern Peruvian highlanders. High Alt Med Biol 18:322-329, 2017.-High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechani...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0148
更新日期：2017-12-01 00:00:00
abstract：:Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2008.1035
更新日期：2008-01-01 00:00:00
abstract：:Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/1527029041352081
更新日期：2004-07-01 00:00:00
abstract：:A variety of neurological disorders other than high altitude cerebral edema have been described at high altitude. This report documents isolated facial and hypoglossal nerve palsies that occurred in two travellers at high altitude in the Nepal Himalaya. The possible pathophysiological mechanisms of these neurological ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702901750265396
更新日期：2001-07-01 00:00:00
abstract：:Acute mountain sickness (AMS) is a common and disabling condition that occurs in healthy individuals ascending to high altitude. Based on the ability of iron to influence cellular oxygen sensing pathways, we hypothesized that iron supplementation would protect against AMS. To examine this hypothesis, 24 healthy sea-le...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2011.1005
更新日期：2011-10-01 00:00:00
abstract：:Although thousands of people ascend 4205 m to visit the summit of Mauna Kea each year, there has been no information on the rate of altitude illness triggered by such visits. Two surveys were used: one for tourists driving up to the summit and the other for summit astronomy workers staying at lodging facilities at int...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2007.8307
更新日期：2007-10-01 00:00:00
