Abstract:
:Shatylo, Valerii B., Tetiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, and Oleg V. Korkushko. Acute hypoxic test in patients with prediabetes. High Alt Med Biol. 17:101-107, 2016.-Prediabetes is a state of impaired carbohydrate metabolism when not all of the symptoms required to label a person as diabetic are present, but blood glucose is higher than in healthy subjects. Recent evidence suggests that intermittent hypoxia training (IHT) might provide a cost-effective strategy for improving metabolic functioning. One of the most important aspects of the successful IHT application is individualized approach to hypoxic dose and regimen prescription. To establish the relationships between indices of carbohydrate metabolism and individual resistance to hypoxia, the acute hypoxic test (AHT, breathing gas mixture with 12% O2 during 20 minutes) was performed in 33 healthy volunteers (mean age, 63.0, range, 44-76; fasting plasma glucose (FPG) less than 5.6 mmol/L and 2 hours postoral glucose tolerance test (OGTT) glycemia less than 7.8 mmol/L) and 30 patients with impaired glucose metabolism (mean age, 65.5, range, 44-75; FPG from 5.6 to 6.9 mmol/L and 2 hours post-OGTT glycemia from 7.8 to 11 mmol/L). Negative correlation was found between the SaO2 level at 20th minute AHT and FPG (r = -0.83; p < 0.01) and insulin (r = -0.27; p < 0.05), as well as 2 hours post-OGTT glucose and insulin levels (r = -0.75 and -0.40, respectively). Longer recovery time and less effective functioning of respiratory and cardiovascular systems were also registered in patients with prediabetes showing that their cardiovascular resilience is impaired compared to normoglycemic controls. These patterns of relationship must be considered when assigning the individual modes of IHT.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Shatylo VB,Serebrovska TV,Gavalko AV,Egorov E,Korkushko OVdoi
10.1089/ham.2015.0117subject
Has Abstractpub_date
2016-06-01 00:00:00pages
101-7issue
2eissn
1527-0297issn
1557-8682journal_volume
17pub_type
杂志文章abstract::The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/152702903322022785
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
pub_type: 传,历史文章,杂志文章
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更新日期:2007-04-01 00:00:00
abstract::Acute altitude exposure may lead to acute mountain sickness (AMS). Increased awareness of altitude-related health hazards in trekkers may accompany a decrease in AMS prevalence. We compared awareness and AMS prevalence in trekkers in two cohorts on an altitude trek up to 5400 m and assessed risk factors for AMS by rep...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
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journal_title:High altitude medicine & biology
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更新日期:2009-10-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
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journal_title:High altitude medicine & biology
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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更新日期:2020-12-01 00:00:00
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journal_title:High altitude medicine & biology
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pub_type: 杂志文章
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journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:High altitude medicine & biology
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更新日期:2007-10-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
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journal_title:High altitude medicine & biology
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