Abstract:
:The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66 +/- 3.1, respectively. Before and after 10 days of IHT, the ventilatory response to sustained hypoxia (SH; 12% O(2) for 10 min), work capacity (bicycle ergometer), and forearm cutaneous perfusion (laser Doppler) were determined. During SH, no negative electrocardiogram (ECG) changes were observed in either group, and the ventilatory response to SH was unaltered by IHT. In Gr 1, IHT (normobaric rebreathing for 5 min, final Sa(O(2)) = 85% to 86%, followed by 5 min normoxia, 4/day) produced no changes in hemodynamic indixes and work capacity. In Gr 2, IHT decreased blood pressure (BP) by 7.9 +/- 3.1 mmHg (p < 0.05) and increased submaximal work by 11.3% (p < 0.05) and anaerobic threshold by 12.7% (p < 0.05). The increase in HR and BP caused by a 55 W-work load was reduced by 5% and 6.5%, respectively (p < 0.05). Cutaneous perfusion increased by 0.06 +/- 0.04 mL/min/100 g in Gr 1 and by 0.11 +/- 0.04 mL/min/100 g in Gr 2 (p < 0.05). Hyperemia recovery time increased significantly by 15.3 +/- 4.6 sec in Gr 1 and by 25.2 +/- 11.2 sec in Gr 2. Thus, healthy senior men well tolerate IHT as performed in this investigation. In untrained, healthy senior men, IHT had greater positive effects on hemodynamics, microvascular endothelial function, and work capacity.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Shatilo VB,Korkushko OV,Ischuk VA,Downey HF,Serebrovskaya TVdoi
10.1089/ham.2007.1053subject
Has Abstractpub_date
2008-04-01 00:00:00pages
43-52issue
1eissn
1527-0297issn
1557-8682journal_volume
9pub_type
杂志文章abstract::Given the high inter-individual variability in the sensitivity to high altitude, we hypothesize the presence of underlying genetic factors. The aim of this study was to construct a genetic predisposition score based on previously identified high-altitude gene variants to explain the inter-individual variation in the r...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1083
更新日期:2015-03-01 00:00:00
abstract::The aim of the present study was to elucidate (1) the cardiovascular adaptations and response to hypoxic stimuli during short-term intermittent hypoxia and (2) whether the change in cardiovascular response to hypoxia is correlated to the change in hypoxic ventilatory chemosensitivity. Fourteen subjects were decompress...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/152702901753397063
更新日期:2001-01-01 00:00:00
abstract::The effects of exposure to acute and chronic high altitude hypoxia on the activity and expression of CYP2E1 and CYP3A1 were examined in rats. Rats were divided into low altitude (LA, 400 m), acute moderate altitude hypoxia (AMH, 2800 m), chronic moderate altitude hypoxia (CMH, 2800 m), acute high altitude hypoxia (AHH...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1026
更新日期:2014-12-01 00:00:00
abstract::Ha, Hoehun. Geographic variation in mentally unhealthy days: air pollution and altitude perspectives. High Alt Med Biol. 18:258-266, 2017. BACKGROUND:Mental health incorporates our emotional, psychological, and social well-being and it is critical at each phase of life, from youth and preadulthood through adulthood. ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0137
更新日期:2017-09-01 00:00:00
abstract::The aims of the present study were to measure the satiety neuropeptide cholecystokinin (CCK) in humans at terrestrial high altitude to investigate its possible role in the pathophysiology of anorexia, cachexia, and acute mountain sickness (AMS). Nineteen male mountaineers aged 38 +/- 12 years participated in a 20 +/- ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702900320649
更新日期:2000-04-01 00:00:00
abstract::Van Iterson, Erik H., Eric M. Snyder, and Bruce D. Johnson. The influence of 17 hours of normobaric hypoxia on parallel adjustments in exhaled nitric oxide and airway function in lowland healthy adults. High Alt Med Biol. 18:1-10, 2017.-Currently, there is a disparate understanding of the role that normobaric hypoxia ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0086
更新日期:2017-03-01 00:00:00
abstract::Frequency of therapeutic beta-blocker use in elderly mountaineers is unknown. Therefore, the aim of this field study was to measure the regular beta-blocker intake in elderly persons visiting moderate altitudes. In a subset of mountaineers on beta-blockers, exercise response at two different altitude levels was compar...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702903322616227
更新日期:2003-01-01 00:00:00
abstract::Allergies and adverse reactions to sulfonamide medications are quite common. Two distinct categories of drugs are classified as sulfonamides: antibiotics and nonantibiotics. The two groups differ in their chemical structure, use, and the rate at which adverse reactions occur. Cross-reactivity between the two groups ha...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2010.1051
更新日期:2010-01-01 00:00:00
abstract::Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2008.1035
更新日期:2008-01-01 00:00:00
abstract::High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied. To fulfill these objectives...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0031
更新日期:2019-03-01 00:00:00
abstract::A variety of neurological disorders other than high altitude cerebral edema have been described at high altitude. This report documents isolated facial and hypoglossal nerve palsies that occurred in two travellers at high altitude in the Nepal Himalaya. The possible pathophysiological mechanisms of these neurological ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702901750265396
更新日期:2001-07-01 00:00:00
abstract:: Background: Perfusion of intrapulmonary arteriovenous anastomoses (IPAVA) is increased during exercise and in hypoxia and is associated with variations in oxygen saturation (SPO2), resulting in blood bypassing the pulmonary microcirculation. Sildenafil is a pulmonary vasod...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2019.0051
更新日期:2019-12-01 00:00:00
abstract::The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sild...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2007.1058
更新日期:2007-07-01 00:00:00
abstract::The purpose of this study was to compare three commonly used scoring systems of acute mountain sickness (AMS)-the 5-item Lake Louise Self-report (LLS), the 11-item abridged version of the Environmental Symptoms Questionnaire (ESQ-III), and a 100 mm visual analog scale (VAS)-on climbers (N=63; 34.6±9.9 years) making a ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1030
更新日期:2012-12-01 00:00:00
abstract::The aim was to establish scientifically supported recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue, which can be applied by physicians and nonphysicians. A literature search was performed; the results and recommendations were discussed among the authors, and finally approved by...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2011.1096
更新日期:2012-09-01 00:00:00
abstract::The present study compares the changes in ventilation in response to sustained hypobaric hypoxia and acute normobaric hypoxia between subjects susceptible to high altitude pulmonary edema (HAPE-S) and control subjects (C-S). Seven HAPE-S and five C-S were exposed to simulated high altitude of 4000 m for 23 h in a hypo...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702902320604241
更新日期:2002-10-01 00:00:00
abstract::Álvarez-Herms, Jesús, Sonia Julià-Sánchez, Hannes Gatterer, Francisco Corbi, Gines Viscor, and Martin Burtscher. Effects of a single power strength training session on heart rate variability when performed at different simulated altitudes. High Alt Med Biol. 21:292-296, 2020. Background: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0014
更新日期:2020-09-01 00:00:00
abstract::To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2005.6.158
更新日期:2005-07-01 00:00:00
abstract::Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/1527029041352081
更新日期:2004-07-01 00:00:00
abstract::Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2017.0061
更新日期:2018-06-01 00:00:00
abstract::Since the first ascent of Mont Blanc by Jacques Balmat and Dr. Michel-Gabriel Paccard in 1786, numerous scientific events have taken place on the highest peak of Europe. Horace Benédict de Saussure, since his first ascent in 1787, made numerous observations on barometric pressure, temperature, geology, and mountain si...
journal_title:High altitude medicine & biology
pub_type: 历史文章,杂志文章
doi:10.1089/152702901750067936
更新日期:2001-04-01 00:00:00
abstract::We describe the case of a 38-year-old man who presented with bilateral retinal detachments following a trek in Tibet during which time he took acetazolamide for prophylaxis of acute mountain sickness (AMS). This is the first time that retinal detachment has been described following a sojourn to high altitude. Acetazol...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1026
更新日期:2007-01-01 00:00:00
abstract::Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru. High Alt Med Biol...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1086
更新日期:2015-03-01 00:00:00
abstract::The purpose of high altitude continuing medical education is to adapt knowledge and skills for practical application on the plateau. Most trainees have experience with academic education and grassroots work experience on the plateau, so they want knowledge about new advances in the pathogenesis, diagnosis, and treatme...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1093
更新日期:2013-06-01 00:00:00
abstract::Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature c...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2013.1016
更新日期:2013-06-01 00:00:00
abstract:AIMS:Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive fa...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2015.0022
更新日期:2015-09-01 00:00:00
abstract::Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort s...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2017.0001
更新日期:2017-09-01 00:00:00
abstract::The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/152702903322022785
更新日期:2003-07-01 00:00:00
abstract:: Aims: Psychotic symptoms during exposure to high altitude (HA) have been linked to accidents or near accidents on the mountains. It is thus of great importance to directly identify psychotic symptoms in individuals who are exposed to HA quickly and reliably on the mountain...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0009
更新日期:2019-12-01 00:00:00
abstract::Bailey, Damian Miles, Benjamin S. Stacey, and Mark Gumbleton. A systematic review and meta-analysis reveals altered drug pharmacokinetics in humans during acute exposure to terrestrial high altitude-clinical justification for dose adjustment? High Alt Med Biol. 19:141-148, 2018. OBJECTIVE:While physiological response...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,meta分析
doi:10.1089/ham.2017.0121
更新日期:2018-06-01 00:00:00