Abstract:
:Frequency of therapeutic beta-blocker use in elderly mountaineers is unknown. Therefore, the aim of this field study was to measure the regular beta-blocker intake in elderly persons visiting moderate altitudes. In a subset of mountaineers on beta-blockers, exercise response at two different altitude levels was compared to matched controls. The observed frequency of beta-blocked persons among the interviewed elderly mountaineers (age >35) was 7%, mainly (65%) due to hypertension. In subjects taking beta-blockers, arterial oxygen saturation (84 +/- 6% vs. 90 +/- 3%, p < 0.05) was decreased and heart rate (120 +/- 17 bpm vs. 112 +/- 14 bpm, p = 0.01), rate pressure product (22,192 +/- 6459 vs. 17,576 +/- 4010, p < 0.05), and ratings of perceived exertion (14 +/- 3 vs. 12 +/- 3, p < 0.05) were increased during a submaximal step test at 2311 m compared to 1480 m. Mountaineers without beta-blocker intake showed no changes. Although the epidemiological data have to be interpreted with caution because of the small sample size and the limitation to a single geographical site, a large number of beta-blocked persons visiting high altitudes was observed. If confirmed in further studies, the increased heart work and exertion could indicate a reduced exercise tolerance of people taking beta-blockers during acute high altitude exposure.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Faulhaber M,Flatz M,Burtscher Mdoi
10.1089/152702903322616227keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
475-8issue
4eissn
1527-0297issn
1557-8682journal_volume
4pub_type
杂志文章abstract::Although thousands of people ascend 4205 m to visit the summit of Mauna Kea each year, there has been no information on the rate of altitude illness triggered by such visits. Two surveys were used: one for tourists driving up to the summit and the other for summit astronomy workers staying at lodging facilities at int...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.8307
更新日期:2007-10-01 00:00:00
abstract::The effects of exposure to acute and chronic high altitude hypoxia on the activity and expression of CYP2E1 and CYP3A1 were examined in rats. Rats were divided into low altitude (LA, 400 m), acute moderate altitude hypoxia (AMH, 2800 m), chronic moderate altitude hypoxia (CMH, 2800 m), acute high altitude hypoxia (AHH...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1026
更新日期:2014-12-01 00:00:00
abstract::The purpose of this study was to elucidate the magnitude and the time course of ventilatory changes resulting from a repeated series of hypoxic exposures. Eight healthy males participated in the present study. The subjects spent 1 h/day in normobaric hypoxia (12% inspired oxygen). Inspired minute ventilation (V(I)), e...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/ham.2005.6.50
更新日期:2005-04-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common condition in individuals who travel to altitudes over 2000 m. While AMS is an important public health problem, no measurements can reliably support or predict the diagnosis with any degree of confidence. We therefore set out to study whether pulse oximetry data are associated ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.341
更新日期:2004-10-01 00:00:00
abstract::The Swiss expedition to Everest (altitude 8,848 m) in the spring of 1952 very nearly attained the summit with two of the climbers reaching 8,595 m. This would have been the first ascent of Everest. One main reason for failure was the inadequate oxygen equipment which was modified from sets designed for mine rescue usi...
journal_title:High altitude medicine & biology
pub_type: 历史文章,杂志文章
doi:10.1089/152702903321488960
更新日期:2003-04-01 00:00:00
abstract::Exposure to hypoxic environments is associated with decreased arterial oxygen saturation and increased pulmonary artery pressures. Ischemic preconditioning of an extremity (IPC) is a procedure that stimulates vasoactive and inflammatory pathways that protect remote organ systems from ongoing or future ischemic injury....
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2013.1137
更新日期:2014-06-01 00:00:00
abstract::The planning and execution of avalanche rescue missions to search for totally buried avalanche victims are mostly based on personal experience and preference, as evidence-based information from literature is almost completely missing. Hence, the aim of this study was to identify major factors determining the survival ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1061
更新日期:2008-10-01 00:00:00
abstract::Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2018.0121
更新日期:2019-06-01 00:00:00
abstract::The aim was to establish scientifically supported recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue, which can be applied by physicians and nonphysicians. A literature search was performed; the results and recommendations were discussed among the authors, and finally approved by...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2011.1096
更新日期:2012-09-01 00:00:00
abstract::Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort s...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2017.0001
更新日期:2017-09-01 00:00:00
abstract::Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru. High Alt Med Biol...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1086
更新日期:2015-03-01 00:00:00
abstract::Survey of on-site treatment of patients in mountain areas of 14 countries in Europe and North America (nonresponder rate 33%) to compare emergency medical services. Around 37,535 ground rescuers and 747 helicopters are ready for evacuation of casualties and patients in mountain areas. And 1316 physicians and 50,967 pa...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2005.6.226
更新日期:2005-10-01 00:00:00
abstract::The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1053
更新日期:2008-04-01 00:00:00
abstract::Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,meta分析,评审
doi:10.1089/ham.2011.1084
更新日期:2012-06-01 00:00:00
abstract::Acute altitude exposure may lead to acute mountain sickness (AMS). Increased awareness of altitude-related health hazards in trekkers may accompany a decrease in AMS prevalence. We compared awareness and AMS prevalence in trekkers in two cohorts on an altitude trek up to 5400 m and assessed risk factors for AMS by rep...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.410
更新日期:2004-01-01 00:00:00
abstract::This study was conducted to investigate the role of the L-type calcium channel in the cardioprotection afforded by chronic intermittent hypobaric hypoxia (CIHH). Rats were exposed to CIHH for 28 days (CIHH28) or 42 days (CIHH42), respectively, before their ventricular myocytes were isolated for electrophysiological st...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1011
更新日期:2010-04-01 00:00:00
abstract::High altitude (HA) presents inhospitable environmental conditions that adversely affects human physiology and metabolism. Changes in physiological functions are reported during high altitude exposure, but the changes vary with physical state, culture habits, geographical locations, and genetic variation of individual....
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1071
更新日期:2013-03-01 00:00:00
abstract::Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-re...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0008
更新日期:2018-12-01 00:00:00
abstract::Chronic hypoxia has a profound effect on uterine artery adaptation to pregnancy. The present studies tested the hypothesis that pregnant kinase C (PKC) differentially regulates alpha(1)-adrenoceptor-mediated contractions and Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to h...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1076
更新日期:2010-07-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common and disabling condition that occurs in healthy individuals ascending to high altitude. Based on the ability of iron to influence cellular oxygen sensing pathways, we hypothesized that iron supplementation would protect against AMS. To examine this hypothesis, 24 healthy sea-le...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2011.1005
更新日期:2011-10-01 00:00:00
abstract::Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/1527029041352081
更新日期:2004-07-01 00:00:00
abstract::Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focu...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2019.0049
更新日期:2019-12-01 00:00:00
abstract::Ha, Hoehun. Geographic variation in mentally unhealthy days: air pollution and altitude perspectives. High Alt Med Biol. 18:258-266, 2017. BACKGROUND:Mental health incorporates our emotional, psychological, and social well-being and it is critical at each phase of life, from youth and preadulthood through adulthood. ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0137
更新日期:2017-09-01 00:00:00
abstract:: Background: Perfusion of intrapulmonary arteriovenous anastomoses (IPAVA) is increased during exercise and in hypoxia and is associated with variations in oxygen saturation (SPO2), resulting in blood bypassing the pulmonary microcirculation. Sildenafil is a pulmonary vasod...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2019.0051
更新日期:2019-12-01 00:00:00
abstract::Shatylo, Valerii B., Tetiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, and Oleg V. Korkushko. Acute hypoxic test in patients with prediabetes. High Alt Med Biol. 17:101-107, 2016.-Prediabetes is a state of impaired carbohydrate metabolism when not all of the symptoms required to label a person as diabetic are pres...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2015.0117
更新日期:2016-06-01 00:00:00
abstract::Otero, Liliana, Patricia Hidalgo, Rafael González, and Carlos A. Morillo. Association of cardiovascular disease and sleep apnea at different altitudes. High Alt Med Biol. 17:336-341, 2016.-We evaluated the prevalence of sleep apnea (SA) in patients with cardiovascular disease (CVD) at different altitudes. A total of 3...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0027
更新日期:2016-12-01 00:00:00
abstract::Luks, Andrew M. Should travelers with hypertension adjust their medications when traveling to high altitude? High Alt. Med. Biol. 10:11-15, 2009.-When advising travelers to high altitude, clinicians should consider how their patient's underlying medical conditions may be affected by the high altitude and whether chang...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2008.1076
更新日期:2009-04-01 00:00:00
abstract::The purpose of high altitude continuing medical education is to adapt knowledge and skills for practical application on the plateau. Most trainees have experience with academic education and grassroots work experience on the plateau, so they want knowledge about new advances in the pathogenesis, diagnosis, and treatme...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1093
更新日期:2013-06-01 00:00:00
abstract:: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0128
更新日期:2019-06-01 00:00:00
abstract::West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0152
更新日期:2017-06-01 00:00:00