Abstract：
: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in this phenomenon. Adiponectin exerts protective effect on cardiovascular system since it modulates NO release, antagonizing endothelial dysfunction. Aims of this study, performed in a selected population of airforce aviators, were (1) to investigate whether exposure to acute HH might be associated with endothelial dysfunction and (2) to evaluate whether adiponectin might be involved in modulating this phenomenon. Methods: Twenty aviators were exposed to acute HH in a hypobaric chamber by simulating altitude of 8000 and then 6000 m for 2 hours. Vascular reactivity was evaluated by the EndoPAT test immediately before and after the HH; salivary and blood adiponectin levels were measured. Results: EndoPAT performed immediately after HH divided pilots in two groups: 12 pilots with preserved vascular reactivity and 8 pilots with reduction of vascular reactivity, indicating that HH exposure might cause endothelial dysfunction. Salivary and blood adiponectin levels increased post-HH in a time-dependent manner in all aviators, but the significant increase was observed only in those with preserved vascular reactivity suggesting that HH stimulated release of adiponectin that, in turn, by exerting a protective effect, might reduce endothelial dysfunction. Conclusions: Acute HH may cause endothelial dysfunction due, at least in part, to reduced release of adiponectin. This phenomenon might be involved in pathophysiology of HARI.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Grittani M,Pellegrino G,Conte S,Morello A,Autore A,Cimmino G,Trimarco B,Morgagni F,Cirillo Pdoi
10.1089/ham.2018.0128subject
Has Abstractpub_date
2019-06-01 00:00:00pages
165-170issue
2eissn
1527-0297issn
1557-8682journal_volume
20pub_type
杂志文章abstract：:A variety of neurological disorders other than high altitude cerebral edema have been described at high altitude. This report documents isolated facial and hypoglossal nerve palsies that occurred in two travellers at high altitude in the Nepal Himalaya. The possible pathophysiological mechanisms of these neurological ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702901750265396
更新日期：2001-07-01 00:00:00
abstract：:The purpose of this study was to elucidate the magnitude and the time course of ventilatory changes resulting from a repeated series of hypoxic exposures. Eight healthy males participated in the present study. The subjects spent 1 h/day in normobaric hypoxia (12% inspired oxygen). Inspired minute ventilation (V(I)), e...
journal_title：High altitude medicine & biology
pub_type： 临床试验,杂志文章
doi：10.1089/ham.2005.6.50
更新日期：2005-04-01 00:00:00
abstract：:The aims of the present study were to measure the satiety neuropeptide cholecystokinin (CCK) in humans at terrestrial high altitude to investigate its possible role in the pathophysiology of anorexia, cachexia, and acute mountain sickness (AMS). Nineteen male mountaineers aged 38 +/- 12 years participated in a 20 +/- ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702900320649
更新日期：2000-04-01 00:00:00
abstract：:The development of mining activities in North Chile involves a great number of workers intermittently exposed to high altitude for a long period of time (chronic intermittent hypoxia, CIH). A 2(1/2)-year prospective study aimed to characterize this model of exposure to CIH and to know whether this condition may progre...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/15270290260131894
更新日期：2002-07-01 00:00:00
abstract：:Wagner, Dale R., Skyler Saunders, Brady Robertson, and John E. Davis. Normobaric hypoxia effects on balance measured by computerized dynamic posturography. High Alt Med Biol. 17:222-227, 2016.-Background/Aim: Equilibrium was measured by computerized dynamic posturography at varying levels of normobaric hypoxia before ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0040
更新日期：2016-09-01 00:00:00
abstract：:Transient focal neurological deficits have been described in sojourners to high altitude. We present two cases of transient expressive aphasia in well-acclimatized high altitude climbers. We speculate that this type of transient focal neurological impairment may represent migraine aura, and we discuss other reports of...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/15270290050144208
更新日期：2000-10-01 00:00:00
abstract：:Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature c...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2013.1016
更新日期：2013-06-01 00:00:00
abstract：:Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort s...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2017.0001
更新日期：2017-09-01 00:00:00
abstract：:Jiang, Tao, Liping Zhao, Yanbo Yin, Huiqian Yu, and Qingzhong Li. Evaluation of middle ear function by tympanometry and the influence of lower barometric pressure at high altitude. High Alt Med Biol 00:000-000, 2020. Objective: To evaluate middle ear function in residents ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2020.0042
更新日期：2020-12-31 00:00:00
abstract：:The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702903322022785
更新日期：2003-07-01 00:00:00
abstract：:Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks ove...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2015.0030
更新日期：2015-06-01 00:00:00
abstract：:High altitude (HA) presents inhospitable environmental conditions that adversely affects human physiology and metabolism. Changes in physiological functions are reported during high altitude exposure, but the changes vary with physical state, culture habits, geographical locations, and genetic variation of individual....
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1071
更新日期：2013-03-01 00:00:00
abstract：AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1091
更新日期：2013-12-01 00:00:00
abstract：:Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focu...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2019.0049
更新日期：2019-12-01 00:00:00
abstract：:To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2005.6.158
更新日期：2005-07-01 00:00:00
abstract：:With the increasing popularity of adventure travel and mountain activities, it is likely that many high altitude travelers will have underlying medical problems and approach clinicians for advice about ensuring a safe sojourn. Patients with underlying pulmonary hypertension are one group who warrants significant conce...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2009.10306
更新日期：2009-10-01 00:00:00
abstract：:Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-re...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0008
更新日期：2018-12-01 00:00:00
abstract：:Alarcón-Yaquetto, Dulce E., Lidia Caballero, and Gustavo F. Gonzales. Association between plasma N-acylethanolamides and high hemoglobin concentration in Southern Peruvian highlanders. High Alt Med Biol 18:322-329, 2017.-High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechani...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0148
更新日期：2017-12-01 00:00:00
abstract：:Since the first ascent of Mont Blanc by Jacques Balmat and Dr. Michel-Gabriel Paccard in 1786, numerous scientific events have taken place on the highest peak of Europe. Horace Benédict de Saussure, since his first ascent in 1787, made numerous observations on barometric pressure, temperature, geology, and mountain si...
journal_title：High altitude medicine & biology
pub_type： 历史文章,杂志文章
doi：10.1089/152702901750067936
更新日期：2001-04-01 00:00:00
abstract：:Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2008.1035
更新日期：2008-01-01 00:00:00
abstract：:Appointing physiological function to specific genetic determinants requires a systems physiologist to consider ways of assessing precise phenotypic mechanisms. The integration of ventilation, metabolism and thermoregulation, for example, is very complex and may differ among small and large mammalian species. This chal...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/152702901750265297
更新日期：2001-07-01 00:00:00
abstract：:Hypoxemia is a major life-threatening complication of childhood pneumonia. The threshold points for hypoxemia vary with altitude. However, few published data describe that normal range of variation. The purpose of this study was to establish reference values of normal mean Sao(2) levels and an approximate cutoff point...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2009.1094
更新日期：2011-04-01 00:00:00
abstract：:Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the w...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2008.1094
更新日期：2009-10-01 00:00:00
abstract：:Over the past 40 years, in an attempt to reduce the morbidity and mortality of altitude illness, a number of volunteer-run, seasonal aid posts have been established at mountain ranges across the world. As each aid post is designed for the local population and tourists at hand, the range of problems seen and services o...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0052
更新日期：2019-12-01 00:00:00
abstract：:High altitude training is a widely used strategy for improving aerobic exercise performance. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements have been reported to improve exercise performance. However, it is not clear whether the provision of R and C during high altitude training could further enhan...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2013.1114
更新日期：2014-09-01 00:00:00
abstract：:Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0121
更新日期：2019-06-01 00:00:00
abstract：:Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,meta分析,评审
doi：10.1089/ham.2011.1084
更新日期：2012-06-01 00:00:00
abstract：:In hypobaric hypoxia (HH) at high altitude, the immune responses are changed probably due to oxidative stress-induced production of free radicals and nonradicals. Vitamin E is an antioxidant and protects the cells from oxidative damage. The present study was carried out to study the antioxidant role of vitamin E on th...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0045
更新日期：2019-03-01 00:00:00
abstract：:West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0152
更新日期：2017-06-01 00:00:00
abstract：:The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sild...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2007.1058
更新日期：2007-07-01 00:00:00
