Venous Thromboembolism at High Altitude: Our Approach to Patients at Risk.

Abstract:

:Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focus of this review, one environmental risk factor, which may interact with other risk factors such as hereditary and/or acquired thrombophilias, is travel to high altitude (HA), although current evidence is limited. As guidelines do not directly address this topic, we will discuss the epidemiology of HA-VTE, review the putative mechanisms for thrombosis at HA, and discuss our clinical approach to both risk stratification and counseling, including specific pharmacologic and nonpharmacologic recommendations for patients with elevated VTE risk before they travel to HA.

journal_name

High Alt Med Biol

authors

Trunk AD,Rondina MT,Kaplan DA

doi

10.1089/ham.2019.0049

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

331-336

issue

4

eissn

1527-0297

issn

1557-8682

journal_volume

20

pub_type

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