Abstract:
:The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sildenafil on echocardiographic indexes of the pulmonary circulation and on cardiopulmonary cycle exercise in normoxia, in acute normobaric hypoxia (fraction of inspired O2, 0.1), and then again after 2 weeks of acclimatization at 5000 m on Mount Chimborazo (Ecuador). In normoxia, sildenafil had no effect on maximum VO2 or O2 saturation. In acute hypoxia, sildenafil increased maximum VO2 from 27 +/- 5 to 32 +/- 6 mL/min/kg and O2 saturation from 62% +/- 6% to 68% +/- 9%. In chronic hypoxia, sildenafil did not affect maximum VO2 or O2 saturation. Resting mean pulmonary artery pressure increased from 16 +/- 3 mmHg in normoxia to 28 +/- 5 mmHg in normobaric hypoxia and 32 +/- 6 mmHg in hypobaric hypoxia. Sildenafil decreased pulmonary vascular resistance by 30% to 50% in these different conditions. We conclude that sildenafil increases exercise capacity in acute normobaric hypoxia and that this is explained by improved arterial oxygenation, rather than by a decrease in right ventricular afterload.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Faoro V,Lamotte M,Deboeck G,Pavelescu A,Huez S,Guenard H,Martinot JB,Naeije Rdoi
10.1089/ham.2007.1058subject
Has Abstractpub_date
2007-07-01 00:00:00pages
155-63issue
2eissn
1527-0297issn
1557-8682journal_volume
8pub_type
杂志文章,随机对照试验abstract::In hypobaric hypoxia (HH) at high altitude, the immune responses are changed probably due to oxidative stress-induced production of free radicals and nonradicals. Vitamin E is an antioxidant and protects the cells from oxidative damage. The present study was carried out to study the antioxidant role of vitamin E on th...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0045
更新日期:2019-03-01 00:00:00
abstract:: Background: The physiological effects of hypoxia may be influenced by how hypoxia is achieved. The purpose of this study was to determine the effects of recovery in hypobaric hypoxia (HH), normobaric hypoxia (NH), and normobaric normoxia (NN) after endurance exercise on ge...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0147
更新日期:2019-06-01 00:00:00
abstract::Allergies and adverse reactions to sulfonamide medications are quite common. Two distinct categories of drugs are classified as sulfonamides: antibiotics and nonantibiotics. The two groups differ in their chemical structure, use, and the rate at which adverse reactions occur. Cross-reactivity between the two groups ha...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2010.1051
更新日期:2010-01-01 00:00:00
abstract::Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2018.0121
更新日期:2019-06-01 00:00:00
abstract::Jiang, Tao, Liping Zhao, Yanbo Yin, Huiqian Yu, and Qingzhong Li. Evaluation of middle ear function by tympanometry and the influence of lower barometric pressure at high altitude. High Alt Med Biol 00:000-000, 2020. Objective: To evaluate middle ear function in residents ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0042
更新日期:2020-12-31 00:00:00
abstract:: Background: Sex-based differences in metabolism and morphological characteristics may result in unique exercise responses during periods of limited oxygen availability. Purpose: To evaluate the effects of moderate normobaric hy...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0061
更新日期:2020-03-01 00:00:00
abstract::Completing a marathon (42.2 km) is one of the more challenging sports activities. Besides the distance, the ambient conditions of the race (altitude, temperature, etc) can increase the physiological demands of the event. The purpose of this study was to investigate the relation between the altitude of the city in whic...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2013.1060
更新日期:2014-04-01 00:00:00
abstract::The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/152702903322022785
更新日期:2003-07-01 00:00:00
abstract::Transient focal neurological deficits have been described in sojourners to high altitude. We present two cases of transient expressive aphasia in well-acclimatized high altitude climbers. We speculate that this type of transient focal neurological impairment may represent migraine aura, and we discuss other reports of...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/15270290050144208
更新日期:2000-10-01 00:00:00
abstract:: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0128
更新日期:2019-06-01 00:00:00
abstract::Although thousands of people ascend 4205 m to visit the summit of Mauna Kea each year, there has been no information on the rate of altitude illness triggered by such visits. Two surveys were used: one for tourists driving up to the summit and the other for summit astronomy workers staying at lodging facilities at int...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.8307
更新日期:2007-10-01 00:00:00
abstract::Frequency of therapeutic beta-blocker use in elderly mountaineers is unknown. Therefore, the aim of this field study was to measure the regular beta-blocker intake in elderly persons visiting moderate altitudes. In a subset of mountaineers on beta-blockers, exercise response at two different altitude levels was compar...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702903322616227
更新日期:2003-01-01 00:00:00
abstract::Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,meta分析,评审
doi:10.1089/ham.2011.1084
更新日期:2012-06-01 00:00:00
abstract::Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/1527029041352081
更新日期:2004-07-01 00:00:00
abstract::Neurological disturbances may be present at high altitude independently of high altitude cerebral edema. We report here the case of a patient who experienced for the first time generalized seizures after spending a night at an altitude of 5200 m, with no preceding symptoms of acute mountain sickness. An initial CT sca...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2006.7.81
更新日期:2006-04-01 00:00:00
abstract::Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort s...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2017.0001
更新日期:2017-09-01 00:00:00
abstract:AIMS:Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive fa...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2015.0022
更新日期:2015-09-01 00:00:00
abstract::Alarcón-Yaquetto, Dulce E., Lidia Caballero, and Gustavo F. Gonzales. Association between plasma N-acylethanolamides and high hemoglobin concentration in Southern Peruvian highlanders. High Alt Med Biol 18:322-329, 2017.-High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechani...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0148
更新日期:2017-12-01 00:00:00
abstract::The aims of the present study were to measure the satiety neuropeptide cholecystokinin (CCK) in humans at terrestrial high altitude to investigate its possible role in the pathophysiology of anorexia, cachexia, and acute mountain sickness (AMS). Nineteen male mountaineers aged 38 +/- 12 years participated in a 20 +/- ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702900320649
更新日期:2000-04-01 00:00:00
abstract::Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-re...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0008
更新日期:2018-12-01 00:00:00
abstract::Álvarez-Herms, Jesús, Sonia Julià-Sánchez, Hannes Gatterer, Francisco Corbi, Gines Viscor, and Martin Burtscher. Effects of a single power strength training session on heart rate variability when performed at different simulated altitudes. High Alt Med Biol. 21:292-296, 2020. Background: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0014
更新日期:2020-09-01 00:00:00
abstract::The aim of the present study was to elucidate (1) the cardiovascular adaptations and response to hypoxic stimuli during short-term intermittent hypoxia and (2) whether the change in cardiovascular response to hypoxia is correlated to the change in hypoxic ventilatory chemosensitivity. Fourteen subjects were decompress...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/152702901753397063
更新日期:2001-01-01 00:00:00
abstract::Wang, Xing-Min, Hui Liu, Jian-Yu Li, Jin-Xia Wei, Xia Li, Yong-Liang Zhang, Ling-Zhi Li, and Xi-Zheng Zhang. Rosamultin attenuates acute hypobaric hypoxia-induced bone injuries by regulation of sclerostin and its downstream signals. High Alt Med Biol. 21:273-286, 2020. Background: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0113
更新日期:2020-09-01 00:00:00
abstract::The present study evaluated the effect of a sleep high-train low regimen on the finger cold-induced vasodilation (CIVD) response. Seventeen healthy males were assigned to either a control (CON; n=9) or experimental (EXP; n=8) group. Each group participated in a 28-day aerobic training program of daily 1-h exercise (50...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2011.1044
更新日期:2012-03-01 00:00:00
abstract::Wagner, Dale R., Skyler Saunders, Brady Robertson, and John E. Davis. Normobaric hypoxia effects on balance measured by computerized dynamic posturography. High Alt Med Biol. 17:222-227, 2016.-Background/Aim: Equilibrium was measured by computerized dynamic posturography at varying levels of normobaric hypoxia before ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0040
更新日期:2016-09-01 00:00:00
abstract:AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1091
更新日期:2013-12-01 00:00:00
abstract::The purpose of this study was to compare three commonly used scoring systems of acute mountain sickness (AMS)-the 5-item Lake Louise Self-report (LLS), the 11-item abridged version of the Environmental Symptoms Questionnaire (ESQ-III), and a 100 mm visual analog scale (VAS)-on climbers (N=63; 34.6±9.9 years) making a ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1030
更新日期:2012-12-01 00:00:00
abstract::Chronic hypoxia has a profound effect on uterine artery adaptation to pregnancy. The present studies tested the hypothesis that pregnant kinase C (PKC) differentially regulates alpha(1)-adrenoceptor-mediated contractions and Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to h...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1076
更新日期:2010-07-01 00:00:00
abstract::The purpose of high altitude continuing medical education is to adapt knowledge and skills for practical application on the plateau. Most trainees have experience with academic education and grassroots work experience on the plateau, so they want knowledge about new advances in the pathogenesis, diagnosis, and treatme...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1093
更新日期:2013-06-01 00:00:00
abstract::Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focu...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2019.0049
更新日期:2019-12-01 00:00:00