Abstract：
:Although thousands of people ascend 4205 m to visit the summit of Mauna Kea each year, there has been no information on the rate of altitude illness triggered by such visits. Two surveys were used: one for tourists driving up to the summit and the other for summit astronomy workers staying at lodging facilities at intermediate altitude. The surveys included the standardized Lake Louise Self-report Acute Mountain Sickness (AMS) Questionnaire that, when scored, gave the Lake Louise Symptoms Score (LLSS). Thirty percent of surveyed day visitors and 69% of surveyed professional astronomy staff had AMS, defined as a LLSS score of 3 or greater, with headache. Nine participants reported "disorientation/confusion" or greater consciousness changes. A majority of astronomy professionals reported fatigue, disturbed sleep, reduced activity, and mental status changes. Few took any AMS medications. The incidence of AMS in visitors to Mauna Kea's summit warrants increased education and increased availability of supplemental oxygen at the summit. The absence of reported serious altitude illness in the community is probably due to the rapid descent available on Mauna Kea, with prompt reversibility of adverse effects.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Onopa J,Haley A,Yeow MEdoi
10.1089/ham.2007.8307subject
Has Abstractpub_date
2007-10-01 00:00:00pages
200-5issue
3eissn
1527-0297issn
1557-8682journal_volume
8pub_type
杂志文章abstract：:The effects of exposure to acute and chronic high altitude hypoxia on the activity and expression of CYP2E1 and CYP3A1 were examined in rats. Rats were divided into low altitude (LA, 400 m), acute moderate altitude hypoxia (AMH, 2800 m), chronic moderate altitude hypoxia (CMH, 2800 m), acute high altitude hypoxia (AHH...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1026
更新日期：2014-12-01 00:00:00
abstract：:The present study reports the possible role of oxidative stress and inflammation (role of nuclear factor, NFkB) in hypoxia-induced transvascular leakage in brain of rats. The rats were exposed to a simulated altitude of 25,000 ft for different durations: 0, 3, 6, 12, 24, and 48h. Brain water content, transvascular lea...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2009.1057
更新日期：2010-10-01 00:00:00
abstract：:Neurological disturbances may be present at high altitude independently of high altitude cerebral edema. We report here the case of a patient who experienced for the first time generalized seizures after spending a night at an altitude of 5200 m, with no preceding symptoms of acute mountain sickness. An initial CT sca...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2006.7.81
更新日期：2006-04-01 00:00:00
abstract：:A 31-year-old man suffered diplopia and ataxia on two occasions when he ascended from sea level to 4,000 m. Evaluation revealed a moderate-sized subarachnoid cyst in the left frontal region, which did not communicate with the cerebral ventricles. The cyst might have acted as a space-occupying lesion, and caused sympto...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/15270290050502417
更新日期：2000-01-01 00:00:00
abstract：:Gou, Qiling, Rufeng Shi, Xin Zhang, Qingtao Meng, Xinran Li, Xi Rong, Zhabu Gawa, Nage Zhuoma, and Xiaoping Chen. The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan Province, China. High Alt Med Biol. 21:327-335, 2020. Background: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2020.0022
更新日期：2020-12-01 00:00:00
abstract：:Completing a marathon (42.2 km) is one of the more challenging sports activities. Besides the distance, the ambient conditions of the race (altitude, temperature, etc) can increase the physiological demands of the event. The purpose of this study was to investigate the relation between the altitude of the city in whic...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2013.1060
更新日期：2014-04-01 00:00:00
abstract：:The purpose of this study was to elucidate the magnitude and the time course of ventilatory changes resulting from a repeated series of hypoxic exposures. Eight healthy males participated in the present study. The subjects spent 1 h/day in normobaric hypoxia (12% inspired oxygen). Inspired minute ventilation (V(I)), e...
journal_title：High altitude medicine & biology
pub_type： 临床试验,杂志文章
doi：10.1089/ham.2005.6.50
更新日期：2005-04-01 00:00:00
abstract：:Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2008.1035
更新日期：2008-01-01 00:00:00
abstract：AIMS:Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive fa...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2015.0022
更新日期：2015-09-01 00:00:00
abstract：:High altitude (HA) presents inhospitable environmental conditions that adversely affects human physiology and metabolism. Changes in physiological functions are reported during high altitude exposure, but the changes vary with physical state, culture habits, geographical locations, and genetic variation of individual....
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1071
更新日期：2013-03-01 00:00:00
abstract：:Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru. High Alt Med Biol...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2014.1086
更新日期：2015-03-01 00:00:00
abstract：:Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/1527029041352081
更新日期：2004-07-01 00:00:00
abstract：:The present study compares the changes in ventilation in response to sustained hypobaric hypoxia and acute normobaric hypoxia between subjects susceptible to high altitude pulmonary edema (HAPE-S) and control subjects (C-S). Seven HAPE-S and five C-S were exposed to simulated high altitude of 4000 m for 23 h in a hypo...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/152702902320604241
更新日期：2002-10-01 00:00:00
abstract：:Otero, Liliana, Patricia Hidalgo, Rafael González, and Carlos A. Morillo. Association of cardiovascular disease and sleep apnea at different altitudes. High Alt Med Biol. 17:336-341, 2016.-We evaluated the prevalence of sleep apnea (SA) in patients with cardiovascular disease (CVD) at different altitudes. A total of 3...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2016.0027
更新日期：2016-12-01 00:00:00
abstract：: Background: Perfusion of intrapulmonary arteriovenous anastomoses (IPAVA) is increased during exercise and in hypoxia and is associated with variations in oxygen saturation (SPO2), resulting in blood bypassing the pulmonary microcirculation. Sildenafil is a pulmonary vasod...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,随机对照试验
doi：10.1089/ham.2019.0051
更新日期：2019-12-01 00:00:00
abstract：:The Swiss expedition to Everest (altitude 8,848 m) in the spring of 1952 very nearly attained the summit with two of the climbers reaching 8,595 m. This would have been the first ascent of Everest. One main reason for failure was the inadequate oxygen equipment which was modified from sets designed for mine rescue usi...
journal_title：High altitude medicine & biology
pub_type： 历史文章,杂志文章
doi：10.1089/152702903321488960
更新日期：2003-04-01 00:00:00
abstract：:Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0121
更新日期：2019-06-01 00:00:00
abstract：:Acute mountain sickness (AMS) is a common condition in individuals who travel to altitudes over 2000 m. While AMS is an important public health problem, no measurements can reliably support or predict the diagnosis with any degree of confidence. We therefore set out to study whether pulse oximetry data are associated ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2004.5.341
更新日期：2004-10-01 00:00:00
abstract：:Wang, Xing-Min, Hui Liu, Jian-Yu Li, Jin-Xia Wei, Xia Li, Yong-Liang Zhang, Ling-Zhi Li, and Xi-Zheng Zhang. Rosamultin attenuates acute hypobaric hypoxia-induced bone injuries by regulation of sclerostin and its downstream signals. High Alt Med Biol. 21:273-286, 2020. Background: ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0113
更新日期：2020-09-01 00:00:00
abstract：:Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focu...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2019.0049
更新日期：2019-12-01 00:00:00
abstract：:The number of avalanche accidents involving winter recreationists has notably increased in recent decades due to the increasing popularity of outdoor winter activities. The International Liaison Committee on Cardiopulmonary Resuscitation, the International Commission for Mountain Emergency Medicine (ICAR Medcom), and ...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2018.0036
更新日期：2018-12-01 00:00:00
abstract：AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2012.1091
更新日期：2013-12-01 00:00:00
abstract：:Shatylo, Valerii B., Tetiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, and Oleg V. Korkushko. Acute hypoxic test in patients with prediabetes. High Alt Med Biol. 17:101-107, 2016.-Prediabetes is a state of impaired carbohydrate metabolism when not all of the symptoms required to label a person as diabetic are pres...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2015.0117
更新日期：2016-06-01 00:00:00
abstract：:Li, Zongbin, Jun Guo, Chunwei Liu, Yajun Shi, Yang Li, Jinli Wang, Dandan Li, Jing Wang, and Yundai Chen. Compound Danshen Dripping Pill promotes adaptation to acute high-altitude exposure. High Alt Med Biol. 21:258-264, 2020. Background: In this study, we aimed to investi...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2019.0126
更新日期：2020-09-01 00:00:00
abstract：:High altitude training is a widely used strategy for improving aerobic exercise performance. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements have been reported to improve exercise performance. However, it is not clear whether the provision of R and C during high altitude training could further enhan...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2013.1114
更新日期：2014-09-01 00:00:00
abstract：:The aim of the present study was to elucidate (1) the cardiovascular adaptations and response to hypoxic stimuli during short-term intermittent hypoxia and (2) whether the change in cardiovascular response to hypoxia is correlated to the change in hypoxic ventilatory chemosensitivity. Fourteen subjects were decompress...
journal_title：High altitude medicine & biology
pub_type： 临床试验,杂志文章
doi：10.1089/152702901753397063
更新日期：2001-01-01 00:00:00
abstract：:Alpinist and scientist George Ingle Finch was invited on the 1921 British Mount Everest Reconnaissance, but events conspired to keep him away from Everest until the 1922 British expedition to the mountain. Very little is known in the English-speaking world about the 1925 German language book Der Kampf um den Everest, ...
journal_title：High altitude medicine & biology
pub_type： 传,历史文章,杂志文章
doi：10.1089/ham.2006.1034
更新日期：2007-04-01 00:00:00
abstract：:In hypobaric hypoxia (HH) at high altitude, the immune responses are changed probably due to oxidative stress-induced production of free radicals and nonradicals. Vitamin E is an antioxidant and protects the cells from oxidative damage. The present study was carried out to study the antioxidant role of vitamin E on th...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2018.0045
更新日期：2019-03-01 00:00:00
abstract：:Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title：High altitude medicine & biology
pub_type： 杂志文章,评审
doi：10.1089/ham.2017.0061
更新日期：2018-06-01 00:00:00
abstract：:Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks ove...
journal_title：High altitude medicine & biology
pub_type： 杂志文章
doi：10.1089/ham.2015.0030
更新日期：2015-06-01 00:00:00
