Abstract:
:The present study reports the possible role of oxidative stress and inflammation (role of nuclear factor, NFkB) in hypoxia-induced transvascular leakage in brain of rats. The rats were exposed to a simulated altitude of 25,000 ft for different durations: 0, 3, 6, 12, 24, and 48h. Brain water content, transvascular leakage, oxidative stress, and proinflammatory parameters were studied at different durations of hypoxic exposure. The results revealed that maximum increase in transvascular leakage in brain of rats was observed at 24h of hypoxic exposure (240.16 ± 1.95 relative fluorescence units (r.f.u)/g tissue) compared with control (100.58 ± 1.79 r.f.u/g tissue). There was a significant increase in reactive oxygen species (ROS) and lipid peroxidation (MDA), with concomitant reduction in antioxidants. Hypoxic exposure resulted in a significant increase in NFκB protein expression levels and in the DNA binding activity in the 24-h hypoxic exposure (p<0.001) compared with control. There was a significant increase in proinflammatory cytokines, with concomitant upregulation of cell adhesion molecules. Simultaneously, to rule out the fact that inflammation causes cerebral edema, the rats were pretreated with curcumin (100 mg/kg body weight) 1h prior to 24-h hypoxia. Curcumin pretreatment significantly attenuated the hypoxia-induced cerebral transvascular leakage (p<0.05), with concomitant downregulation in the expression of brain NFκB levels (p<0.001). The present study therefore reveals that inflammation (NFκB) plays a significant role in hypoxia-induced cerebral edema.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Himadri P,Kumari SS,Chitharanjan M,Dhananjay Sdoi
10.1089/ham.2009.1057subject
Has Abstractpub_date
2010-10-01 00:00:00pages
231-44issue
3eissn
1527-0297issn
1557-8682journal_volume
11pub_type
杂志文章abstract::The development of mining activities in North Chile involves a great number of workers intermittently exposed to high altitude for a long period of time (chronic intermittent hypoxia, CIH). A 2(1/2)-year prospective study aimed to characterize this model of exposure to CIH and to know whether this condition may progre...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/15270290260131894
更新日期:2002-07-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0022
更新日期:2020-12-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2013.1060
更新日期:2014-04-01 00:00:00
abstract::A variety of neurological disorders other than high altitude cerebral edema have been described at high altitude. This report documents isolated facial and hypoglossal nerve palsies that occurred in two travellers at high altitude in the Nepal Himalaya. The possible pathophysiological mechanisms of these neurological ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/152702901750265396
更新日期:2001-07-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2019.0051
更新日期:2019-12-01 00:00:00
abstract::To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2005.6.158
更新日期:2005-07-01 00:00:00
abstract::Shatylo, Valerii B., Tetiana V. Serebrovska, Anna V. Gavalko, Egor Egorov, and Oleg V. Korkushko. Acute hypoxic test in patients with prediabetes. High Alt Med Biol. 17:101-107, 2016.-Prediabetes is a state of impaired carbohydrate metabolism when not all of the symptoms required to label a person as diabetic are pres...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2015.0117
更新日期:2016-06-01 00:00:00
abstract::Luks, Andrew M. Should travelers with hypertension adjust their medications when traveling to high altitude? High Alt. Med. Biol. 10:11-15, 2009.-When advising travelers to high altitude, clinicians should consider how their patient's underlying medical conditions may be affected by the high altitude and whether chang...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2008.1076
更新日期:2009-04-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0126
更新日期:2020-09-01 00:00:00
abstract:: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0128
更新日期:2019-06-01 00:00:00
abstract::The Swiss expedition to Everest (altitude 8,848 m) in the spring of 1952 very nearly attained the summit with two of the climbers reaching 8,595 m. This would have been the first ascent of Everest. One main reason for failure was the inadequate oxygen equipment which was modified from sets designed for mine rescue usi...
journal_title:High altitude medicine & biology
pub_type: 历史文章,杂志文章
doi:10.1089/152702903321488960
更新日期:2003-04-01 00:00:00
abstract::Otero, Liliana, Patricia Hidalgo, Rafael González, and Carlos A. Morillo. Association of cardiovascular disease and sleep apnea at different altitudes. High Alt Med Biol. 17:336-341, 2016.-We evaluated the prevalence of sleep apnea (SA) in patients with cardiovascular disease (CVD) at different altitudes. A total of 3...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0027
更新日期:2016-12-01 00:00:00
abstract::This study was conducted to investigate the role of the L-type calcium channel in the cardioprotection afforded by chronic intermittent hypobaric hypoxia (CIHH). Rats were exposed to CIHH for 28 days (CIHH28) or 42 days (CIHH42), respectively, before their ventricular myocytes were isolated for electrophysiological st...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2009.1011
更新日期:2010-04-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1061
更新日期:2008-10-01 00:00:00
abstract::The aim of the present study was to elucidate (1) the cardiovascular adaptations and response to hypoxic stimuli during short-term intermittent hypoxia and (2) whether the change in cardiovascular response to hypoxia is correlated to the change in hypoxic ventilatory chemosensitivity. Fourteen subjects were decompress...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/152702901753397063
更新日期:2001-01-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1091
更新日期:2013-12-01 00:00:00
abstract::Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2017.0061
更新日期:2018-06-01 00:00:00
abstract::High altitude training is a widely used strategy for improving aerobic exercise performance. Both Rhodiola crenulata (R) and Cordyceps sinensis (C) supplements have been reported to improve exercise performance. However, it is not clear whether the provision of R and C during high altitude training could further enhan...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2013.1114
更新日期:2014-09-01 00:00:00
abstract::The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.1053
更新日期:2008-04-01 00:00:00
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journal_title:High altitude medicine & biology
pub_type: 传,历史文章,杂志文章
doi:10.1089/ham.2006.1034
更新日期:2007-04-01 00:00:00
abstract::Acute altitude exposure may lead to acute mountain sickness (AMS). Increased awareness of altitude-related health hazards in trekkers may accompany a decrease in AMS prevalence. We compared awareness and AMS prevalence in trekkers in two cohorts on an altitude trek up to 5400 m and assessed risk factors for AMS by rep...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.410
更新日期:2004-01-01 00:00:00
abstract::High altitude (HA) presents inhospitable environmental conditions that adversely affects human physiology and metabolism. Changes in physiological functions are reported during high altitude exposure, but the changes vary with physical state, culture habits, geographical locations, and genetic variation of individual....
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2012.1071
更新日期:2013-03-01 00:00:00
abstract::A 31-year-old man suffered diplopia and ataxia on two occasions when he ascended from sea level to 4,000 m. Evaluation revealed a moderate-sized subarachnoid cyst in the left frontal region, which did not communicate with the cerebral ventricles. The cyst might have acted as a space-occupying lesion, and caused sympto...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/15270290050502417
更新日期:2000-01-01 00:00:00
abstract::The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sild...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2007.1058
更新日期:2007-07-01 00:00:00
abstract::Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focu...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2019.0049
更新日期:2019-12-01 00:00:00
abstract::The influence of oxygen pressure on placental and villous vascular development is reviewed and considered relative to the natural experiment afforded by residence at high altitude. Data obtained from normal high altitude pregnancies are compared with those from IUGR and preeclampsia, conditions believed to be caused b...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/152702903322022785
更新日期:2003-07-01 00:00:00
abstract::Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2018.0121
更新日期:2019-06-01 00:00:00
abstract::Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2008.1035
更新日期:2008-01-01 00:00:00
abstract::The male reproductive functions of the members of the Masherbrum (7821 m) Expedition in 1999 were examined via semen analyses and endocrine tests. Specimens were collected from three subjects who had stayed above 5100 m for 21 to 24 days and above 6700 m for 4 to 5 days before departure and 1 month, 3 months, and 2 yr...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/152702903769192304
更新日期:2003-10-01 00:00:00
abstract::Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the w...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2008.1094
更新日期:2009-10-01 00:00:00