The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia.

abstract：:The present study compares the changes in ventilation in response to sustained hypobaric hypoxia and acute normobaric hypoxia between subjects susceptible to high altitude pulmonary edema (HAPE-S) and control subjects (C-S). Seven HAPE-S and five C-S were exposed to simulated high altitude of 4000 m for 23 h in a hypo...

journal_title：High altitude medicine & biology

authors： Schirlo C,Pavlicek V,Jacomet A,Gibbs JS,Koller E,Oelz O,Seebauer M,Kohl J

更新日期：2002-10-01 00:00:00

abstract：:High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied. To fulfill these objectives...

journal_title：High altitude medicine & biology

authors： Khanna K,Mishra KP,Chanda S,Eslavath MR,Ganju L,Kumar B,Singh SB

更新日期：2019-03-01 00:00:00

abstract：:The male reproductive functions of the members of the Masherbrum (7821 m) Expedition in 1999 were examined via semen analyses and endocrine tests. Specimens were collected from three subjects who had stayed above 5100 m for 21 to 24 days and above 6700 m for 4 to 5 days before departure and 1 month, 3 months, and 2 yr...

journal_title：High altitude medicine & biology

authors： Okumura A,Fuse H,Kawauchi Y,Mizuno I,Akashi T

更新日期：2003-10-01 00:00:00

abstract：:The phosphodiesterase-5 inhibitor sildenafil has been reported to improve hypoxic exercise capacity, but the mechanisms accounting for this observation remain incompletely understood. Sixteen healthy subjects were included in a randomized, double-blind, placebo-controlled, cross-over study on the effects of 50-mg sild...

journal_title：High altitude medicine & biology

authors： Faoro V,Lamotte M,Deboeck G,Pavelescu A,Huez S,Guenard H,Martinot JB,Naeije R

更新日期：2007-07-01 00:00:00

abstract：:Acute altitude exposure may lead to acute mountain sickness (AMS). Increased awareness of altitude-related health hazards in trekkers may accompany a decrease in AMS prevalence. We compared awareness and AMS prevalence in trekkers in two cohorts on an altitude trek up to 5400 m and assessed risk factors for AMS by rep...

journal_title：High altitude medicine & biology

authors： Gaillard S,Dellasanta P,Loutan L,Kayser B

更新日期：2004-01-01 00:00:00

abstract：:To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...

journal_title：High altitude medicine & biology

authors： Pesce C,Leal C,Pinto H,González G,Maggiorini M,Schneider M,Bärtsch P

更新日期：2005-07-01 00:00:00

abstract：:Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention ...

journal_title：High altitude medicine & biology

authors： Kayser B,Dumont L,Lysakowski C,Combescure C,Haller G,Tramèr MR

更新日期：2012-06-01 00:00:00

abstract：:A 31-year-old man suffered diplopia and ataxia on two occasions when he ascended from sea level to 4,000 m. Evaluation revealed a moderate-sized subarachnoid cyst in the left frontal region, which did not communicate with the cerebral ventricles. The cyst might have acted as a space-occupying lesion, and caused sympto...

journal_title：High altitude medicine & biology

authors： Hackett PH

更新日期：2000-01-01 00:00:00

abstract：:Jiang, Tao, Liping Zhao, Yanbo Yin, Huiqian Yu, and Qingzhong Li. Evaluation of middle ear function by tympanometry and the influence of lower barometric pressure at high altitude. High Alt Med Biol 00:000-000, 2020. Objective: To evaluate middle ear function in residents ...

journal_title：High altitude medicine & biology

authors： Jiang T,Zhao L,Yin Y,Yu H,Li Q

更新日期：2020-12-31 00:00:00

abstract：:Chronic hypoxia has a profound effect on uterine artery adaptation to pregnancy. The present studies tested the hypothesis that pregnant kinase C (PKC) differentially regulates alpha(1)-adrenoceptor-mediated contractions and Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to h...

journal_title：High altitude medicine & biology

authors： Xiao D,Huang X,Longo LD,Zhang L

更新日期：2010-07-01 00:00:00

abstract：AIMS:Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive fa...

journal_title：High altitude medicine & biology

authors： Waeber B,Kayser B,Dumont L,Lysakowski C,Tramèr MR,Elia N

更新日期：2015-09-01 00:00:00

abstract：:With the increasing popularity of adventure travel and mountain activities, it is likely that many high altitude travelers will have underlying medical problems and approach clinicians for advice about ensuring a safe sojourn. Patients with underlying pulmonary hypertension are one group who warrants significant conce...

journal_title：High altitude medicine & biology

authors： Luks AM

更新日期：2009-10-01 00:00:00

abstract：: Background: Perfusion of intrapulmonary arteriovenous anastomoses (IPAVA) is increased during exercise and in hypoxia and is associated with variations in oxygen saturation (SPO2), resulting in blood bypassing the pulmonary microcirculation. Sildenafil is a pulmonary vasod...

journal_title：High altitude medicine & biology

authors： Carter EA,Koch S,O'Donovan JP,Sheel AW,Milsom WK,Koehle MS

更新日期：2019-12-01 00:00:00

abstract：:Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...

journal_title：High altitude medicine & biology

authors： Canepa CA,Harris NS

更新日期：2019-06-01 00:00:00

abstract：:The planning and execution of avalanche rescue missions to search for totally buried avalanche victims are mostly based on personal experience and preference, as evidence-based information from literature is almost completely missing. Hence, the aim of this study was to identify major factors determining the survival ...

journal_title：High altitude medicine & biology

authors： Hohlrieder M,Thaler S,Wuertl W,Voelckel W,Ulmer H,Brugger H,Mair P

更新日期：2008-10-01 00:00:00

abstract：:Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the w...

journal_title：High altitude medicine & biology

authors： Dunin-Bell O,Boyle S

更新日期：2009-10-01 00:00:00

abstract：:Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature c...

journal_title：High altitude medicine & biology

authors： Welsh DJ,Peacock AJ

更新日期：2013-06-01 00:00:00

abstract：:Frostbite and other cold-related injuries commonly develop during prolonged exposure to the low environmental temperatures of polar and mountainous regions. Hypoxia is a potent sympathetic stimulus that causes vasoconstriction of the peripheral blood vessels, which may further compound the risk of developing a cold-re...

journal_title：High altitude medicine & biology

authors： Jones D,Covins SF,Miller GE,Morrison KI,Clark AG,Calcott SD,Anderson AM,Lucas SJE,Imray CHE

更新日期：2018-12-01 00:00:00

abstract：:Bailey, Damian Miles, Benjamin S. Stacey, and Mark Gumbleton. A systematic review and meta-analysis reveals altered drug pharmacokinetics in humans during acute exposure to terrestrial high altitude-clinical justification for dose adjustment? High Alt Med Biol. 19:141-148, 2018. OBJECTIVE:While physiological response...

journal_title：High altitude medicine & biology

authors： Bailey DM,Stacey BS,Gumbleton M

更新日期：2018-06-01 00:00:00

abstract：:Chronic mountain sickness (CMS) and high altitude pulmonary edema (HAPE) each occur rarely in Tibetans, and they have previously not been reported in the same person. Here we describe a 37-year-old native Tibetan man with CMS at 4300 m, who developed HAPE after his return home from a 12-day visit to sea level. Possibl...

journal_title：High altitude medicine & biology

authors： Wu T

更新日期：2004-07-01 00:00:00

abstract：AIMS:Examined the change in neurobehavioral function of individuals acclimated to high altitudes and those native to high altitudes. METHODS:A neurobehavioral core test battery approved by the WHO (WHO-NCTB) was used to evaluate the effects of high altitude hypoxia on neurobehavioral function. The WHO-NCTB is composed...

journal_title：High altitude medicine & biology

authors： Zhang G,Zhou SM,Yuan C,Tian HJ,Li P,Gao YQ

更新日期：2013-12-01 00:00:00

abstract：:Hypoxemia is a major life-threatening complication of childhood pneumonia. The threshold points for hypoxemia vary with altitude. However, few published data describe that normal range of variation. The purpose of this study was to establish reference values of normal mean Sao(2) levels and an approximate cutoff point...

journal_title：High altitude medicine & biology

authors： Schult S,Canelo-Aybar C

更新日期：2011-04-01 00:00:00

abstract：:In hypobaric hypoxia (HH) at high altitude, the immune responses are changed probably due to oxidative stress-induced production of free radicals and nonradicals. Vitamin E is an antioxidant and protects the cells from oxidative damage. The present study was carried out to study the antioxidant role of vitamin E on th...

journal_title：High altitude medicine & biology

authors： Goswami AR,Ghosh T

更新日期：2019-03-01 00:00:00

abstract：:Hamm, Wolfgang, Sari Kassem, Lukas von Stülpnagel, Florian Maier, Mathias Klemm, Dominik Schüttler, Felix Grabher, Ludwig T. Weckbach, Bruno C. Huber, Axel Bauer, Konstantinos D. Rizas, and Stefan Brunner. Deceleration capacity and periodic repolarization dynamics as predictors of acute mountain sickness. High Alt Med...

journal_title：High altitude medicine & biology

authors： Hamm W,Kassem S,von Stülpnagel L,Maier F,Klemm M,Schüttler D,Grabher F,Weckbach LT,Huber BC,Bauer A,Rizas KD,Brunner S

更新日期：2020-12-01 00:00:00

abstract：:Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...

journal_title：High altitude medicine & biology

authors： Thiersch M,Swenson ER

更新日期：2018-06-01 00:00:00

abstract：:The purpose of this study was to elucidate the magnitude and the time course of ventilatory changes resulting from a repeated series of hypoxic exposures. Eight healthy males participated in the present study. The subjects spent 1 h/day in normobaric hypoxia (12% inspired oxygen). Inspired minute ventilation (V(I)), e...

journal_title：High altitude medicine & biology

authors： Katayama K,Fujita H,Sato K,Ishida K,Iwasaki K,Miyamura M

更新日期：2005-04-01 00:00:00

abstract：:This study was conducted to investigate the role of the L-type calcium channel in the cardioprotection afforded by chronic intermittent hypobaric hypoxia (CIHH). Rats were exposed to CIHH for 28 days (CIHH28) or 42 days (CIHH42), respectively, before their ventricular myocytes were isolated for electrophysiological st...

journal_title：High altitude medicine & biology

authors： Zhang Y,Zhong N,Zhou ZN

更新日期：2010-04-01 00:00:00

abstract：: Aims: Psychotic symptoms during exposure to high altitude (HA) have been linked to accidents or near accidents on the mountains. It is thus of great importance to directly identify psychotic symptoms in individuals who are exposed to HA quickly and reliably on the mountain...

journal_title：High altitude medicine & biology

authors： Hüfner K,Brugger H,Caramazza F,Stawinoga AE,Brodmann-Maeder M,Gatterer H,Turner R,Tomazin I,Fusar-Poli P,Sperner-Unterweger B

更新日期：2019-12-01 00:00:00

abstract：: Background: Platelets are the key factor in primary hemostasis. It has been shown that chronic altitude exposure increases platelets' aggregability. Nevertheless, data about acute effects and the underlying mechanisms are sparse. Methods: ...

journal_title：High altitude medicine & biology

authors： Lackermair K,Schuhmann CG,Mertsch P,Götschke J,Milger K,Brunner S

更新日期：2019-09-01 00:00:00

abstract：:The number of avalanche accidents involving winter recreationists has notably increased in recent decades due to the increasing popularity of outdoor winter activities. The International Liaison Committee on Cardiopulmonary Resuscitation, the International Commission for Mountain Emergency Medicine (ICAR Medcom), and ...

journal_title：High altitude medicine & biology

authors： Strapazzon G,Brugger H

更新日期：2018-12-01 00:00:00