Abstract:
:A 36-year-old woman with no medical history participated in a trekking in Ladakh up to 5300 m of altitude. She was well acclimatized and presented no previous sign of acute mountain sickness, high altitude pulmonary edema or high altitude cerebral edema. After an intense effort to catch up with her group, she became breathless and complained of visual disturbances, fatigue, dizziness, and confusion. During her descent to a lower altitude (4800 m), with the help of companions, she lost consciousness several times. After a 14-hour sleep, she recovered and all symptoms disappeared so that she was able to walk along with the group for 20 km. On returning home, she went through a battery of examinations that were all normal: cerebral magnetic resonance imaging, Doppler of supra-aortic arteries, 24 hours Holter, and cardiac transthoracic and transesophageal echography. A hypoxia exercise test revealed a hyper-response to hypoxia with severe hypocapnia. The etiology of this neurological episode is discussed (transient embolic ischemic attack, migraine, cerebral edema, and global amnesia). The patchy distribution of neurological symptoms is not in favor of a thrombotic event. The most probable diagnosis proposed is a transient cerebral ischemia due to local cerebral vasoconstriction related to hyperventilation-induced hypocapnia in a context of acute severe exercise. Special attention should be given to subjects who show a hyper-responsiveness to hypoxia before a sojourn at high altitude: they should avoid unnecessary hyperventilation due to any kind of stress, emotion, or exhaustive exercise.
journal_name
High Alt Med Bioljournal_title
High altitude medicine & biologyauthors
Richalet JP,Larmignat P,Poignard Pdoi
10.1089/ham.2019.0100subject
Has Abstractpub_date
2020-03-01 00:00:00pages
105-108issue
1eissn
1527-0297issn
1557-8682journal_volume
21pub_type
杂志文章abstract::Although thousands of people ascend 4205 m to visit the summit of Mauna Kea each year, there has been no information on the rate of altitude illness triggered by such visits. Two surveys were used: one for tourists driving up to the summit and the other for summit astronomy workers staying at lodging facilities at int...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2007.8307
更新日期:2007-10-01 00:00:00
abstract::To investigate the determinants of acute mountain sickness (AMS) and of summiting in expedition-style mountaineering, 919 mountaineers (15.4% female) leaving Aconcagua Provincial Park at the end of an expedition to Mt. Aconcagua (6962 m) via the normal route were retrospectively evaluated by questionnaires. Symptoms o...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2005.6.158
更新日期:2005-07-01 00:00:00
abstract::The aim was to establish scientifically supported recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue, which can be applied by physicians and nonphysicians. A literature search was performed; the results and recommendations were discussed among the authors, and finally approved by...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2011.1096
更新日期:2012-09-01 00:00:00
abstract::Li, Zongbin, Jun Guo, Chunwei Liu, Yajun Shi, Yang Li, Jinli Wang, Dandan Li, Jing Wang, and Yundai Chen. Compound Danshen Dripping Pill promotes adaptation to acute high-altitude exposure. High Alt Med Biol. 21:258-264, 2020. Background: In this study, we aimed to investi...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2019.0126
更新日期:2020-09-01 00:00:00
abstract::The Swiss expedition to Everest (altitude 8,848 m) in the spring of 1952 very nearly attained the summit with two of the climbers reaching 8,595 m. This would have been the first ascent of Everest. One main reason for failure was the inadequate oxygen equipment which was modified from sets designed for mine rescue usi...
journal_title:High altitude medicine & biology
pub_type: 历史文章,杂志文章
doi:10.1089/152702903321488960
更新日期:2003-04-01 00:00:00
abstract::Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,meta分析,评审
doi:10.1089/ham.2011.1084
更新日期:2012-06-01 00:00:00
abstract::Given the high inter-individual variability in the sensitivity to high altitude, we hypothesize the presence of underlying genetic factors. The aim of this study was to construct a genetic predisposition score based on previously identified high-altitude gene variants to explain the inter-individual variation in the r...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1083
更新日期:2015-03-01 00:00:00
abstract::West, John B. Are permanent residents of high altitude fully adapted to their hypoxic environment? High Alt Med Biol. 18:135-139, 2017.-Millions of people live permanently at high altitude and many have been there for generations. It is sometimes claimed that these people have completely adapted to their environment, ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0152
更新日期:2017-06-01 00:00:00
abstract::High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation are the major problems induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up to 14 days at 7620 m on GI immune function have been studied. To fulfill these objectives...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0031
更新日期:2019-03-01 00:00:00
abstract::With the increasing popularity of adventure travel and mountain activities, it is likely that many high altitude travelers will have underlying medical problems and approach clinicians for advice about ensuring a safe sojourn. Patients with underlying pulmonary hypertension are one group who warrants significant conce...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2009.10306
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Abnormally high pulmonary artery pressure (PAP) in hypoxia due to exaggerated hypoxic pulmonary vasoconstriction (HPV) is a key factor for development of high-altitude pulmonary edema (HAPE). It was shown that about 10% of a healthy Caucasian population has an exaggerated HPV that is comparable to the respon...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1117
更新日期:2015-03-01 00:00:00
abstract::Alpinist and scientist George Ingle Finch was invited on the 1921 British Mount Everest Reconnaissance, but events conspired to keep him away from Everest until the 1922 British expedition to the mountain. Very little is known in the English-speaking world about the 1925 German language book Der Kampf um den Everest, ...
journal_title:High altitude medicine & biology
pub_type: 传,历史文章,杂志文章
doi:10.1089/ham.2006.1034
更新日期:2007-04-01 00:00:00
abstract::Alarcón-Yaquetto, Dulce E., Lidia Caballero, and Gustavo F. Gonzales. Association between plasma N-acylethanolamides and high hemoglobin concentration in Southern Peruvian highlanders. High Alt Med Biol 18:322-329, 2017.-High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechani...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0148
更新日期:2017-12-01 00:00:00
abstract::Climbers who have suffered a previous episode of high altitude pulmonary edema (HAPE) are at significantly increased risk of developing it again on return to high altitude. In spite of the high mortality associated with HAPE, some climbers are willing to take this risk in order to summit the tallest mountains in the w...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2008.1094
更新日期:2009-10-01 00:00:00
abstract::Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this revie...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2018.0121
更新日期:2019-06-01 00:00:00
abstract:: Background: Platelets are the key factor in primary hemostasis. It has been shown that chronic altitude exposure increases platelets' aggregability. Nevertheless, data about acute effects and the underlying mechanisms are sparse. Methods: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0112
更新日期:2019-09-01 00:00:00
abstract::Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2008.1035
更新日期:2008-01-01 00:00:00
abstract::Richalet, Jean-Paul, and François J. Lhuissier. Aging, tolerance to high altitude, and cardiorespiratory response to hypoxia. High Alt Med Biol. 16:117-124, 2015.--It is generally accepted that aging is rather protective, at least at moderate altitude. Some anecdotal reports even mention successful ascent of peaks ove...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2015.0030
更新日期:2015-06-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common condition in individuals who travel to altitudes over 2000 m. While AMS is an important public health problem, no measurements can reliably support or predict the diagnosis with any degree of confidence. We therefore set out to study whether pulse oximetry data are associated ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2004.5.341
更新日期:2004-10-01 00:00:00
abstract::The purpose of this study was to elucidate the magnitude and the time course of ventilatory changes resulting from a repeated series of hypoxic exposures. Eight healthy males participated in the present study. The subjects spent 1 h/day in normobaric hypoxia (12% inspired oxygen). Inspired minute ventilation (V(I)), e...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/ham.2005.6.50
更新日期:2005-04-01 00:00:00
abstract::Keyes, Linda E., Thomas Douglas Sallade, Charles Duke, Jennifer Starling, Alison Sheets, Sushil Pant, David S. Young, David Twillman, Nirajan Regmi, Benoit Phelan, Purshotam Paudel, Matthew McElwee, Luke Mather, Devlin Cole, Theodore McConnell, and Buddha Basnyat. Blood pressure and altitude: an observational cohort s...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2017.0001
更新日期:2017-09-01 00:00:00
abstract::The aim of the present study was to elucidate (1) the cardiovascular adaptations and response to hypoxic stimuli during short-term intermittent hypoxia and (2) whether the change in cardiovascular response to hypoxia is correlated to the change in hypoxic ventilatory chemosensitivity. Fourteen subjects were decompress...
journal_title:High altitude medicine & biology
pub_type: 临床试验,杂志文章
doi:10.1089/152702901753397063
更新日期:2001-01-01 00:00:00
abstract::Allergies and adverse reactions to sulfonamide medications are quite common. Two distinct categories of drugs are classified as sulfonamides: antibiotics and nonantibiotics. The two groups differ in their chemical structure, use, and the rate at which adverse reactions occur. Cross-reactivity between the two groups ha...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2010.1051
更新日期:2010-01-01 00:00:00
abstract::We conducted a survey of equipment in medical backpacks for mountain rescuers and mountain emergency physicians. The aim was to investigate whether there are standards for medical equipment in mountain rescue organizations associated with the International Commission for Mountain Emergency Medicine (ICAR MEDCOM). A qu...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2010.1048
更新日期:2011-01-01 00:00:00
abstract::Ha, Hoehun. Geographic variation in mentally unhealthy days: air pollution and altitude perspectives. High Alt Med Biol. 18:258-266, 2017. BACKGROUND:Mental health incorporates our emotional, psychological, and social well-being and it is critical at each phase of life, from youth and preadulthood through adulthood. ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2016.0137
更新日期:2017-09-01 00:00:00
abstract:: Background: Hypobaric hypoxia (HH) increases the risk of high altitude-related illnesses (HARI). The pathophysiological mechanism(s) involved are still partially unknown. Altered vascular reactivity as consequence of endothelial dysfunction during HH might play a role in t...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2018.0128
更新日期:2019-06-01 00:00:00
abstract::Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt Med Biol 19:116-123, 2018.-Humans living at high altitude (HA) are exposed to chronic (hypobaric) hypoxia. Despite the permanent stress of hypoxic exposure, humans populating HA areas have reduced cancer mortality over a broad spectrum...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,评审
doi:10.1089/ham.2017.0061
更新日期:2018-06-01 00:00:00
abstract::Gou, Qiling, Rufeng Shi, Xin Zhang, Qingtao Meng, Xinran Li, Xi Rong, Zhabu Gawa, Nage Zhuoma, and Xiaoping Chen. The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan Province, China. High Alt Med Biol. 21:327-335, 2020. Background: ...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2020.0022
更新日期:2020-12-01 00:00:00
abstract::Acute mountain sickness (AMS) is a common and disabling condition that occurs in healthy individuals ascending to high altitude. Based on the ability of iron to influence cellular oxygen sensing pathways, we hypothesized that iron supplementation would protect against AMS. To examine this hypothesis, 24 healthy sea-le...
journal_title:High altitude medicine & biology
pub_type: 杂志文章,随机对照试验
doi:10.1089/ham.2011.1005
更新日期:2011-10-01 00:00:00
abstract::Painschab, Matthew S., Gary E. Malpartida, Victor G. Davila-Roman, Robert H. Gilman, Todd M. Kolb, Fabiola Leon-Velarde, J. Jaime Miranda, and William Checkley. Association between serum concentrations of hypoxia inducible factor responsive proteins and excessive erythrocytosis in high altitude Peru. High Alt Med Biol...
journal_title:High altitude medicine & biology
pub_type: 杂志文章
doi:10.1089/ham.2014.1086
更新日期:2015-03-01 00:00:00