Abstract：
:Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the only retrovirus known to cause cancer in humans. Viral lymphomas behave aggressively and disproportionally affect immunocompromised individuals and those living in underdeveloped regions. These diseases are often difficult to treat with conventional approaches. Despite recent advancements using cytotoxic, lymphoma-specific, and adoptive therapies, the long-term outcome of patients with γ-herpesvirus lymphomas occurring in severely immunocompromised patients and ATLL continues to be poor. Lytic-inducing therapies targeting NF-κB, and viral and tumor cell epigenetic mechanisms afford the advantage of exploiting the intrinsic presence of oncogenic viruses to eradicate infected tumor cells. In this review, viral-related lymphomas and newly emerging clinical approaches targeting viral latency are discussed.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Ramos JC,Lossos ISdoi
10.1007/s11912-011-0186-8subject
Has Abstractpub_date
2011-10-01 00:00:00pages
416-26issue
5eissn
1523-3790issn
1534-6269journal_volume
13pub_type
杂志文章,评审abstract：:Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected. Evidence to support this is now emerging as the Not...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-008-0071-2
更新日期：2008-11-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-005-0065-2
更新日期：2005-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-001-0052-1
更新日期：2001-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-008-0052-5
更新日期：2008-07-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-013-0361-1
更新日期：2014-01-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-002-0017-z
更新日期：2002-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：1999-09-01 00:00:00
abstract：PURPOSE OF REVIEW:The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate stan...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-00951-6
更新日期：2020-07-10 00:00:00
abstract：:The evolution of our ability to diagnose and classify lymphomas in an increasingly refined manner has paralleled the development of novel technologic approaches, with contemporary practice dependent upon the harnessing of a plethora of data that include microscopic, immunophenotypic, and genetic information. Although ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2004-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-002-0006-2
更新日期：2002-07-01 00:00:00
abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0673-2
更新日期：2018-04-10 00:00:00
abstract：PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-00969-w
更新日期：2020-08-15 00:00:00
abstract：PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-019-0845-8
更新日期：2019-11-07 00:00:00
abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors (ICI) are only effective in a subset of patients. Here, we will review the rationale and data supporting the combination of PD-1 pathway inhibition with recombinant cytokines and neoantigen-based cancer vaccines that can potentially increase the number of patients who will...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0738-2
更新日期：2018-11-15 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-00923-w
更新日期：2020-06-20 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-000-0108-7
更新日期：2000-11-01 00:00:00
abstract：:Most of the experience with second-line chemotherapy for non-small-cell lung cancer (NSCLC) comes from small phase II trials, which have shown disappointing or inconsistent results. The notable exception has been docetaxel, which has been extensively studied as a second-line therapy for NSCLC. On the basis of consiste...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-000-0016-x
更新日期：2000-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-019-0856-5
更新日期：2019-11-14 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-019-0833-z
更新日期：2019-08-15 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-017-0586-5
更新日期：2017-04-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章
doi：10.1007/s11912-006-0045-1
更新日期：2006-03-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-016-0505-1
更新日期：2016-04-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-017-0640-3
更新日期：2017-11-06 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-006-0070-0
更新日期：2006-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Although surgery for lung cancer was not common before the early twentieth century, it has enjoyed remarkable progress since then both in type of resection and technical approach. This has been coupled with significant technological advances. Here, we will review the history and evolution of this rela...
journal_title：Current oncology reports
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s11912-018-0741-7
更新日期：2018-11-13 00:00:00
abstract：:Cutaneous melanoma is a significant and increasing clinical problem. Knowing accurately the prognosis in a given patient is critical for treatment decisions and for optimal patient education. In this article we discuss the most current information regarding prognostic factors in early-stage and advanced malignant mela...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-000-0025-9
更新日期：2000-07-01 00:00:00
abstract：:Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservat...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-006-0016-6
更新日期：2006-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-017-0639-9
更新日期：2017-10-28 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/BF02951428
更新日期：2007-01-01 00:00:00
