Abstract:
PURPOSE OF REVIEW:The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate standard therapy of GBM with 6 weeks of radiochemotherapy. RECENT FINDINGS:A set of alleviated therapies, e.g., chemotherapy or radiotherapy alone, hypofractionated radiotherapies with different total doses and variable fractionation regimens as well as hypofractionated radiotherapy with concomitant and adjuvant chemotherapy, have been evaluated during the last years. However, clinicians are still unsure which therapy would fit best to a given patient. Recently, the predictive value of comprehensive geriatric assessment regarding tolerance of chemotherapy and prediction of early mortality has been validated for older GBM patients in a retrospective trial. Thus, it appears that neuro-oncology is now ready for the prospective implementation of geriatric assessment to guide treatment planning for elderly GBM patients.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Lütgendorf-Caucig C,Freyschlag C,Masel EK,Marosi Cdoi
10.1007/s11912-020-00951-6subject
Has Abstractpub_date
2020-07-10 00:00:00pages
93issue
9eissn
1523-3790issn
1534-6269pii
10.1007/s11912-020-00951-6journal_volume
22pub_type
杂志文章,评审abstract::The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of me...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0065-2
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abstract::There has been much development in the field of targeted therapy for melanoma stemming from efforts to decrease treatment-related toxicities and enhance specific cytotoxicity. This review focuses on three modalities of targeted melanoma therapy based on the biology of the targeting mechanism. The first of these modali...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of less than 2 years despite the standard of care treatment of 6 weeks of chemoradiotherapy. We review the data investigating hypofractionated radiotherapy (HFRT) in the treatment of newly diagnosed ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0616-3
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journal_title:Current oncology reports
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0630-5
更新日期:2017-09-07 00:00:00
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journal_title:Current oncology reports
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-000-0108-7
更新日期:2000-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2018-05-04 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00989-6
更新日期:2021-01-02 00:00:00
abstract::The utility of lymphatic mapping and sentinel lymph node biopsy in malignancies of the female lower genital tract-- vulvar, vaginal, and cervical cancers--is being explored in multiple centers internationally. For patients with these tumors, lymphatic mapping with sentinel lymph node biopsy holds the promise of increa...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0008-y
更新日期:2005-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0007-6
更新日期:2001-03-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0073-9
更新日期:2001-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-012-0270-8
更新日期:2012-12-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
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更新日期:2018-04-02 00:00:00
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journal_title:Current oncology reports
pub_type: 历史文章,杂志文章,评审
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更新日期:2018-11-13 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-016-0499-8
更新日期:2016-03-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0056-6
更新日期:2007-09-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-009-0059-6
更新日期:2009-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-016-0558-1
更新日期:2016-12-01 00:00:00