MEK inhibition in the treatment of advanced melanoma.

abstract：:Pediatric medicine is moving toward a greater appreciation that the delivery of quality medical care involves a partnership including the health care team, the child, and the family. Pediatric medicine now emphasizes the importance of information exchange among these groups. This paper discusses two models for communi...

journal_title：Current oncology reports

authors： Weidner NJ

更新日期：2007-11-01 00:00:00

abstract：:Adjuvant treatment of patients with endometrial cancer is tailored to clinical-pathological prognostic factors. Pelvic radiation therapy for stage I endometrial cancer (EC) provides a highly significant improvement of local control, but without survival advantage. Low-risk EC patients have a very favorable prognosis, ...

journal_title：Current oncology reports

authors： Creutzberg CL,Nout RA

更新日期：2011-12-01 00:00:00

abstract：:The diagnosis of a gynecological malignancy during pregnancy is rare but not uncommon. Cancer treatment during pregnancy is possible, but both maternal and fetal interests need to be respected. Different treatment plans may be justifiable and multidisciplinary treatment is advised. Clinical trials are virtually imposs...

journal_title：Current oncology reports

authors： Han SN,Verheecke M,Vandenbroucke T,Gziri MM,Van Calsteren K,Amant F

更新日期：2014-12-01 00:00:00

abstract：:Soft tissue sarcomas (STS) consist of a heterogeneous group of rare malignancies arising from mesenchymal origin. While surgical resection is the primary treatment for STS, the use of radiotherapy (RT) as an adjunctive modality has been shown to improve oncologic outcomes. Technologic improvements, such as image guida...

journal_title：Current oncology reports

authors： Blumenfeld P,Sen N,Abrams R,Wang D

更新日期：2016-06-01 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia are diagnosed at an early stage, when traditional staging systems fail to distinguish those with an aggressive disease course from those with an excellent prognosis. This failure underscores the need for better prognostic markers. Although many markers have been explored...

journal_title：Current oncology reports

authors： Jain N,Lamanna N

更新日期：2009-09-01 00:00:00

abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...

journal_title：Current oncology reports

authors： Rich TA,Crane C,Lawson JD,Landry J

更新日期：2005-05-01 00:00:00

abstract：:Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...

journal_title：Current oncology reports

authors： Ullrich NJ,Pomeroy SL

更新日期：2006-11-01 00:00:00

abstract：:Colon cancer remains the third most common cancer, and cause of cancer-related death in the United States. Greater public awareness and acceptance of screening programs have contributed significantly to increasingly earlier detection of colon cancer and decreased mortality. Advances made in the understanding of this d...

journal_title：Current oncology reports

authors： Kumar SK,Goldberg RM

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, e...

journal_title：Current oncology reports

authors： Sclafani F,Rao S

更新日期：2018-05-04 00:00:00

abstract：:In the past, the treatment options for patients with metastatic prostate cancer that progressed despite castrate levels of testosterone was limited, and no therapies provided an improvement in survival. The majority of these patients had extensive osseous disease, multiple comorbidities, and poor performance status. W...

journal_title：Current oncology reports

authors： Kelly WK,Slovin SF

更新日期：2000-09-01 00:00:00

abstract：:Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the...

journal_title：Current oncology reports

authors： Ramos JC,Lossos IS

更新日期：2011-10-01 00:00:00

abstract：:Postmastectomy radiotherapy continues to be one of the most controversial issues in breast radiotherapy. At the crux of the controversy lies the lack of conclusive studies that specifically address the risk-benefit ratio of postmastectomy radiotherapy for patients at intermediate risk of developing locoregional recurr...

journal_title：Current oncology reports

authors： Sartor CI

更新日期：2006-01-01 00:00:00

abstract：:Many women undergo mastectomy as treatment of their breast cancer either because of personal preference or because of tumor-related factors making mastectomy the preferred surgical option. The use of postmastectomy radiation therapy has been shown to decrease the risk of local recurrence and in some cases improve over...

journal_title：Current oncology reports

authors： Lyons JA,Sherertz T

更新日期：2014-01-01 00:00:00

abstract：:Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has emerged as an attractive option in the development of targeted cancer therapy. Three oral agents selectively targeting CDK4/6 have been developed: palbociclib, ...

journal_title：Current oncology reports

authors： Mayer EL

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...

journal_title：Current oncology reports

authors： Yao CMKL,Chang EI,Lai SY

更新日期：2019-11-07 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of ...

journal_title：Current oncology reports

authors： Palmieri DJ,Carlino MS

更新日期：2018-07-31 00:00:00

abstract：:Chemotherapy was traditionally perceived to be ineffective for prostate cancer and was only administered to patients with symptomatic hormone-refractory disease. Although previous reviews have confirmed this belief, recent studies have demonstrated significant antitumor activity with chemotherapy regimens. This articl...

journal_title：Current oncology reports

authors： Petrylak DP

更新日期：2003-05-01 00:00:00

abstract：:There has been much development in the field of targeted therapy for melanoma stemming from efforts to decrease treatment-related toxicities and enhance specific cytotoxicity. This review focuses on three modalities of targeted melanoma therapy based on the biology of the targeting mechanism. The first of these modali...

journal_title：Current oncology reports

authors： Brown CK,Kirkwood JM

更新日期：2001-07-01 00:00:00

abstract：:Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates despite correct multidisciplinary management. Metastatic disease implies a poor pr...

journal_title：Current oncology reports

authors： Marquina G,Manzano A,Casado A

更新日期：2018-04-02 00:00:00

abstract：:Epidemiologic data presented in this review suggest the involvement of hepatitis C virus (HCV) in the patho- genesis of some histotypes of B-cell non-Hodgkin's lymphoma, in particular immunocytoma and lymphomas growing primarily in the liver and major salivary glands. Experimental data further support this hypothesis....

journal_title：Current oncology reports

authors： Silvestri F,Sperotto A,Fanin R

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma (MCL) prognosis is strictly related to the characteristics of the disease, which can range from very indolent cases to highly aggressive and refractory ones. Here we will review the current knowledge on MCL biomarkers. RECENT FINDINGS:Biomarker-informed diagnosis is essential for...

journal_title：Current oncology reports

authors： Condoluci A,Rossi D,Zucca E,Cavalli F

更新日期：2018-08-22 00:00:00

abstract：:High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction. Management of these tumors demands awareness of the characteristics contributing to their recurrence. Recent studies e...

journal_title：Current oncology reports

authors： Lai SY,Weber RS

更新日期：2005-03-01 00:00:00

abstract：:The establishment of the Intergroup Rhabdomyosarcoma Study (IRS) Committee in 1972 by three extant American pediatric cooperative groups initiated five generations of studies in the multidisciplinary treatment of soft-tissue sarcomas. Taking the lead from the use of vincristine, actinomycin-D, and cyclophosphamide (VA...

journal_title：Current oncology reports

authors： Ruymann FB

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Older adults with cancer have complex medical needs and often experience higher rates of treatment-related toxicities compared to their younger counterparts. The advent of health information technologies can address multiple gaps in the care of this population. We review the role of existing and emerg...

journal_title：Current oncology reports

authors： Loh KP,McHugh C,Mohile SG,Mustian K,Flannery M,Klepin H,Schnall R,Culakova E,Ramsdale E

更新日期：2018-03-06 00:00:00

abstract：:Mutations in the cancer susceptibility genes BRCA1 and BRCA2 are associated with significantly increased risks of breast and ovarian cancer. Fortunately, effective strategies are available to reduce these risks, including genetic testing, which is an important consideration in determining management of patients with a...

journal_title：Current oncology reports

authors： Gulati AP,Domchek SM

更新日期：2008-01-01 00:00:00

abstract：:Accurate, reproducible criteria for determining tumor response and progression after therapy are critical for optimal patient care and effective evaluation of novel therapeutic agents. Currently, the most widely used criteria for determining treatment response in gliomas is based on two-dimensional tumor measurements ...

journal_title：Current oncology reports

authors： Wen PY,Norden AD,Drappatz J,Quant E

更新日期：2010-01-01 00:00:00

abstract：:While there is an ongoing debate regarding the timing of the maximal surgical effort in epithelial ovarian cancer, it is well established that patients with suboptimal tumor debulking derive no benefit from the surgical procedure. The amount of residual disease after cytoreductive surgery has been repeatedly identifie...

journal_title：Current oncology reports

authors： Narasimhulu DM,Khoury-Collado F,Chi DS

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

journal_title：Current oncology reports

authors： Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

更新日期：2018-04-10 00:00:00

abstract：:Electronic data sharing is a critical, but underappreciated, requirement for modern medical informatics systems. This capability is facilitated by acquisition of structured clinical data, but optimized only if this data is stored and transmitted using standardized representations. Most electronic medical record and cl...

journal_title：Current oncology reports

authors： Jones RB,Reeves D,Martinez CS

更新日期：2012-12-01 00:00:00

abstract：:Aflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic effects that functions as a decoy receptor to bind vascular endothelial growth factors A and B and placental growth factor. Its unique mechanism of action with respect to o...

journal_title：Current oncology reports

authors： Ciombor KK,Berlin J

更新日期：2014-02-01 00:00:00