Early chemohormonal therapy in prostate cancer: preliminary data and randomized trials.

abstract：:Vascular endothelial growth factor (VEGF) is the term used for a family of tumor-derived angiogenic factors that mediate endothelial proliferation and vascular permeability. Preclinical models have demonstrated the essential nature of VEGF in the angiogenesis of solid tumor growth and metastasis, whereas pathologic in...

journal_title：Current oncology reports

authors： Margolin K

更新日期：2002-01-01 00:00:00

abstract：:Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...

journal_title：Current oncology reports

authors： Ullrich NJ,Pomeroy SL

更新日期：2006-11-01 00:00:00

abstract：:There has been much development in the field of targeted therapy for melanoma stemming from efforts to decrease treatment-related toxicities and enhance specific cytotoxicity. This review focuses on three modalities of targeted melanoma therapy based on the biology of the targeting mechanism. The first of these modali...

journal_title：Current oncology reports

authors： Brown CK,Kirkwood JM

更新日期：2001-07-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCL) are rare and aggressive subtypes of non-Hodgkin's lymphoma. Compared to B cell lymphomas, the immunologic phenotype of PTCL portends a poorer prognosis, with the exception of anaplastic large cell lymphoma bearing the anaplastic lymphoma kinase protein. Patients with PTCL tend to pre...

journal_title：Current oncology reports

authors： Casulo C,Horwitz S

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Standard treatment for early-stage squamous cell cancer of the anal canal (SCCA) includes concurrent chemotherapy and radiation to achieve curative intent. Treatment options are limited, however, especially with locoregional disease relapse occurring in 20-30% of patients and about 10-30% of patients ...

journal_title：Current oncology reports

authors： Phuong L,Rajdev L

更新日期：2020-07-11 00:00:00

abstract：:Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has emerged as an attractive option in the development of targeted cancer therapy. Three oral agents selectively targeting CDK4/6 have been developed: palbociclib, ...

journal_title：Current oncology reports

authors： Mayer EL

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...

journal_title：Current oncology reports

authors： Tang E,Lahmi L,Meillan N,Pietta G,Albert S,Maingon P

更新日期：2019-11-14 00:00:00

abstract：:After decades of reluctance to change surgical approaches, new technologies have created new perspectives for surgery. Initially, the laparoscopic approach was considered to be only one useful for relatively simple procedures as the design of the instruments and the limited access hampered free movements to perform co...

journal_title：Current oncology reports

authors： Verheijen R,Zweemer R

更新日期：2012-12-01 00:00:00

abstract：:Proton beam radiation therapy (PBRT) has unique physical properties (e.g., Bragg Peak) that limit the amount of normal tissue irradiated in the head and neck region while maximizing the radiation delivered to the tumor. Radiation therapy is commonly used in both the primary and adjuvant setting for many head and neck ...

journal_title：Current oncology reports

authors： Frank SJ,Selek U

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in cervical cancer screening and treatment have resulted in high cure rates in developed countries for early-stage disease. Current research focuses on minimizing morbidity and maximizing quality of life. RECENT FINDINGS:Imaging has been disappointing in identifying small volume metastases. ...

journal_title：Current oncology reports

authors： Zigras T,Lennox G,Willows K,Covens A

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...

journal_title：Current oncology reports

authors： Gentzler RD,Riley DO,Martin LW

更新日期：2020-08-15 00:00:00

abstract：:The establishment of the Intergroup Rhabdomyosarcoma Study (IRS) Committee in 1972 by three extant American pediatric cooperative groups initiated five generations of studies in the multidisciplinary treatment of soft-tissue sarcomas. Taking the lead from the use of vincristine, actinomycin-D, and cyclophosphamide (VA...

journal_title：Current oncology reports

authors： Ruymann FB

更新日期：2003-11-01 00:00:00

abstract：:The topoisomerase I inhibitors such as irinotecan and topotecan are active agents against small-cell lung cancer that are effective in treating not only chemotherapy-naïve tumors but also progressed-stage tumors after treatment with cisplatin-based regimens, because their mechanism of antitumor activity differs from t...

journal_title：Current oncology reports

authors： Ohe Y,Saijo N

更新日期：2001-03-01 00:00:00

abstract：:The utility of lymphatic mapping and sentinel lymph node biopsy in malignancies of the female lower genital tract-- vulvar, vaginal, and cervical cancers--is being explored in multiple centers internationally. For patients with these tumors, lymphatic mapping with sentinel lymph node biopsy holds the promise of increa...

journal_title：Current oncology reports

authors： Frumovitz M,Ramirez PT,Levenback C

更新日期：2005-11-01 00:00:00

abstract：:Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1A1, CYP2D6, and CYP...

journal_title：Current oncology reports

authors： Clapper ML

更新日期：2000-05-01 00:00:00

abstract：:Management of tumors of the salivary glands requires a detailed understanding of the anatomy and pathologic processes affecting these glands. Salivary glands give rise to benign and malignant neoplasms and are affected by a variety of systemic diseases. CT remains the most common primary imaging study; magnetic resona...

journal_title：Current oncology reports

authors： Scianna JM,Petruzzelli GJ

更新日期：2007-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...

journal_title：Current oncology reports

authors： Robins HI,Chang S,Butowski N,Mehta M

更新日期：2007-01-01 00:00:00

abstract：:Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected. Evidence to support this is now emerging as the Not...

journal_title：Current oncology reports

authors： Zweidler-McKay PA

更新日期：2008-11-01 00:00:00

abstract：:Epidemiologic studies supported by molecular technology have provided sufficient evidence of the causal role of some human papillomavirus (HPV) infections in the development of cervical cancer. The finding is consistent universally, and HPV has been proposed as the first identified necessary cause of cervical cancer. ...

journal_title：Current oncology reports

authors： Bosch FX,de Sanjosé S

更新日期：2002-03-01 00:00:00

abstract：:Epidemiologic data presented in this review suggest the involvement of hepatitis C virus (HCV) in the patho- genesis of some histotypes of B-cell non-Hodgkin's lymphoma, in particular immunocytoma and lymphomas growing primarily in the liver and major salivary glands. Experimental data further support this hypothesis....

journal_title：Current oncology reports

authors： Silvestri F,Sperotto A,Fanin R

更新日期：2000-03-01 00:00:00

abstract：:There is no clear consensus regarding the most effective management of poor responders to neoadjuvant chemotherapy. Intensifying or changing primary systemic treatment has not been shown to offer any benefit. There is a paucity of trials testing the utility of adjuvant chemotherapy in this setting. Adjuvant hormonal t...

journal_title：Current oncology reports

authors： Wesolowski R,Budd GT

更新日期：2009-01-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...

journal_title：Current oncology reports

authors： von Mehren M

更新日期：2003-07-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of death from cancer worldwide and has a poor overall survival across all stages of disease. The recent advancement of gene expression technology addresses the phenotypic complexity of many diseases, including NSCLC. These genomic approaches have shown great prom...

journal_title：Current oncology reports

authors： Jolly Graham A,Potti A

更新日期：2009-07-01 00:00:00

abstract：:Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservat...

journal_title：Current oncology reports

authors： Das P,Crane CH

更新日期：2006-05-01 00:00:00

abstract：:Osteoporosis is a disease that causes substantial morbidity and mortality for which preventive therapy is available. Women with breast cancer are at increased risk for osteoporosis for several reasons, including premature ovarian failure as a result of treatment, direct effects of chemotherapy, and effects of the brea...

journal_title：Current oncology reports

authors： Mincey BA

更新日期：2003-01-01 00:00:00

abstract：:Cutaneous melanoma is a significant and increasing clinical problem. Knowing accurately the prognosis in a given patient is critical for treatment decisions and for optimal patient education. In this article we discuss the most current information regarding prognostic factors in early-stage and advanced malignant mela...

journal_title：Current oncology reports

authors： Buzaid AC,Anderson CM

更新日期：2000-07-01 00:00:00

abstract：:Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil (5-FU) and mitomycin results in high rates of local control and...

journal_title：Current oncology reports

authors： Czito BG,Willett CG

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

journal_title：Current oncology reports

authors： Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

更新日期：2018-04-10 00:00:00

abstract：:The original version of this article, which published in Current Oncology Reports, Volume 21, Issue 6, June 2019, contained an error in addressing the indication for use of neratinib in early stage breast cancer. ...

journal_title：Current oncology reports

authors： Leone JP,Lin NU

更新日期：2019-05-17 00:00:00

abstract：:Neuroblastoma is the most common extracranial tumor of childhood, with about 650 new cases each year in the United States. The clinical course of neuroblastoma is variable and depends on age at diagnosis, staging, histology, and specific genetic abnormalities, such as MYCN oncogene amplification or aberrations of chro...

journal_title：Current oncology reports

authors： Mueller S,Matthay KK

更新日期：2009-11-01 00:00:00