Preoperative and adjuvant treatment of localized rectal cancer.

abstract：PURPOSE OF REVIEW:The calculation of noncancer-specific life expectancy can guide shared decision-making and avoid over- and undertreatment in older adults with cancer. Several factors determine life expectancy, including socio-demographic background, comorbidities, physical performance, and geriatric assessment variab...

journal_title：Current oncology reports

authors： Verduzco-Aguirre HC,Gomez-Moreno C,Chavarri-Guerra Y,Soto-Perez-de-Celis E

更新日期：2019-06-25 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

journal_title：Current oncology reports

authors： Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

更新日期：2018-04-10 00:00:00

abstract：:Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...

journal_title：Current oncology reports

authors： Bradshaw M,Mansfield A,Peikert T

更新日期：2013-06-01 00:00:00

abstract：:Hypogonadism is common throughout the illness trajectory of patients with cancer. About two thirds of male patients with advanced cancer have hypothalamic-pituitary-gonadal dysfunction and low testosterone levels. Chronic inflammation, comorbidities, cachexia, chemotherapy, and medications such as opioids, megestrol a...

journal_title：Current oncology reports

authors： Dev R,Bruera E,Del Fabbro E

更新日期：2014-04-01 00:00:00

abstract：:Many women undergo mastectomy as treatment of their breast cancer either because of personal preference or because of tumor-related factors making mastectomy the preferred surgical option. The use of postmastectomy radiation therapy has been shown to decrease the risk of local recurrence and in some cases improve over...

journal_title：Current oncology reports

authors： Lyons JA,Sherertz T

更新日期：2014-01-01 00:00:00

abstract：:Soft tissue sarcomas (STS) consist of a heterogeneous group of rare malignancies arising from mesenchymal origin. While surgical resection is the primary treatment for STS, the use of radiotherapy (RT) as an adjunctive modality has been shown to improve oncologic outcomes. Technologic improvements, such as image guida...

journal_title：Current oncology reports

authors： Blumenfeld P,Sen N,Abrams R,Wang D

更新日期：2016-06-01 00:00:00

abstract：:Options for treatment of poor-prognosis or relapsed acute myeloid leukemia (AML) remain limited. Gemtuzumab ozogamicin (Mylotarg, Wyeth-Ayerst, Philadelphia, PA) is an immunoconjugate composed of recombinant humanized murine anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent. Phase II trials have sho...

journal_title：Current oncology reports

authors： Stadtmauer EA

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in cervical cancer screening and treatment have resulted in high cure rates in developed countries for early-stage disease. Current research focuses on minimizing morbidity and maximizing quality of life. RECENT FINDINGS:Imaging has been disappointing in identifying small volume metastases. ...

journal_title：Current oncology reports

authors： Zigras T,Lennox G,Willows K,Covens A

更新日期：2017-08-01 00:00:00

abstract：:In the past, the treatment options for patients with metastatic prostate cancer that progressed despite castrate levels of testosterone was limited, and no therapies provided an improvement in survival. The majority of these patients had extensive osseous disease, multiple comorbidities, and poor performance status. W...

journal_title：Current oncology reports

authors： Kelly WK,Slovin SF

更新日期：2000-09-01 00:00:00

abstract：PURPOSE REVIEW:B cell signaling agents, including ibrutinib, idelalisib, and the BCL-2 inhibitor venetoclax have become an integral part of therapy for patients with non-Hodgkin's lymphomas. The toxicity profiles of these medications is distinct from chemoimmunotherapy. Here, we will review the mechanism of action of t...

journal_title：Current oncology reports

authors： Rhodes J,Mato A,Sharman JP

更新日期：2018-04-11 00:00:00

abstract：:Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths in American men. Although the use of the prostate-specific antigen (PSA) test for prostate cancer screening since the 1990s has led to increased early diagnoses, the most recent studies are in conflict about the risks and b...

journal_title：Current oncology reports

authors： Cook ED,Nelson AC

更新日期：2011-02-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is a disease associated with fusion oncoproteins invariably involving the retinoic acid receptor (Raralpha). Retinoic acid induces differentiation in APL cells and is successfully used in conjunction with chemotherapy to treat and cure a significant percentage of patients with APL. A...

journal_title：Current oncology reports

authors： Mann KK,Shao W,Miller WH Jr

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the long scientific background followed to design guidelines and everyday clinical practice applied to melanoma patients. Surgery is the first option to cure melanoma patients (PTS) at initial diagnosis, since primary cutaneous lesions are usually easily resectable. An excisional...

journal_title：Current oncology reports

authors： Testori AAE,Blankenstein SA,van Akkooi ACJ

更新日期：2019-12-19 00:00:00

abstract：:Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor...

journal_title：Current oncology reports

authors： Pawlik TM,Choti MA

更新日期：2007-05-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common soft tissue sarcoma, and most feature abnormalities in two genes encoding the receptor tyrosine kinases (RTKs), KIT, and PDGFRA. The RTK inhibitor imatinib revolutionized treatment in GIST; however, drug resistance remains a challenge. Constitutive autophosph...

journal_title：Current oncology reports

authors： Patel S

更新日期：2013-08-01 00:00:00

abstract：:The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become the standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target...

journal_title：Current oncology reports

authors： Hayman SR,Leung N,Grande JP,Garovic VD

更新日期：2012-08-01 00:00:00

abstract：:Accurate, reproducible criteria for determining tumor response and progression after therapy are critical for optimal patient care and effective evaluation of novel therapeutic agents. Currently, the most widely used criteria for determining treatment response in gliomas is based on two-dimensional tumor measurements ...

journal_title：Current oncology reports

authors： Wen PY,Norden AD,Drappatz J,Quant E

更新日期：2010-01-01 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) and their related pathways represent some of the most attractive targets in the development of anticancer therapeutics. Among a variety of CDK inhibitors under development, flavopiridol, UCN-01, CYC202, and BMS-387032 are undergoing clinical evaluation based on evidence of preclinical a...

journal_title：Current oncology reports

authors： Dai Y,Grant S

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Standard treatment for early-stage squamous cell cancer of the anal canal (SCCA) includes concurrent chemotherapy and radiation to achieve curative intent. Treatment options are limited, however, especially with locoregional disease relapse occurring in 20-30% of patients and about 10-30% of patients ...

journal_title：Current oncology reports

authors： Phuong L,Rajdev L

更新日期：2020-07-11 00:00:00

abstract：PURPOSE OF REVIEW:Older adults with cancer have complex medical needs and often experience higher rates of treatment-related toxicities compared to their younger counterparts. The advent of health information technologies can address multiple gaps in the care of this population. We review the role of existing and emerg...

journal_title：Current oncology reports

authors： Loh KP,McHugh C,Mohile SG,Mustian K,Flannery M,Klepin H,Schnall R,Culakova E,Ramsdale E

更新日期：2018-03-06 00:00:00

abstract：:The success of the angiogenesis inhibitor bevacizumab, the vascular endothelial growth factor antagonist that was recently shown to significantly improve the survival of patients with metastatic colon cancer when administered in combination with conventional chemotherapy, has provided proof of principle in clinical tr...

journal_title：Current oncology reports

authors： Moses MA,Harper J,Fernández CA

更新日期：2004-01-01 00:00:00

abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...

journal_title：Current oncology reports

authors： Rich TA,Crane C,Lawson JD,Landry J

更新日期：2005-05-01 00:00:00

abstract：:Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...

journal_title：Current oncology reports

authors： Ullrich NJ,Pomeroy SL

更新日期：2006-11-01 00:00:00

abstract：:This review briefly summarizes the results of previous systemic (chemotherapy) and local (surgery and radiotherapy) treatment attempted to date for malignant mesothelioma. The prospects for newer modalities, ie molecular and biologic therapies, are also highlighted, including results of both preclinical and early clin...

journal_title：Current oncology reports

authors： Smythe WR

更新日期：2002-07-01 00:00:00

abstract：:The prodrug strategy has its own particular real and theoretic obstacles. Clinical strategies and research efforts have tried to approach these problems. The bystander effect, whereby nontransduced cells are affected by simple proximity to those that have received the novel gene, has enabled many prodrug systems to be...

journal_title：Current oncology reports

authors： Smythe WR

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...

journal_title：Current oncology reports

authors： Upshaw JN

更新日期：2020-06-20 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...

journal_title：Current oncology reports

authors： von Mehren M

更新日期：2003-07-01 00:00:00

abstract：:Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With t...

journal_title：Current oncology reports

authors： Shukla NN,Trippett TM

更新日期：2006-09-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...

journal_title：Current oncology reports

authors： Robins HI,Chang S,Butowski N,Mehta M

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Improved management of infectious complications of acute myeloid leukemia (AML) has contributed substantially to the success of care over the past half century. An important approach to reducing infectious complications during the induction period of chemotherapy involves the use of prophylactic antib...

journal_title：Current oncology reports

authors： McCarthy MW,Walsh TJ

更新日期：2017-03-01 00:00:00