Current therapy for malignant mesothelioma.


:This review briefly summarizes the results of previous systemic (chemotherapy) and local (surgery and radiotherapy) treatment attempted to date for malignant mesothelioma. The prospects for newer modalities, ie molecular and biologic therapies, are also highlighted, including results of both preclinical and early clinical research.


Curr Oncol Rep


Current oncology reports


Smythe WR





Has Abstract


2002-07-01 00:00:00












  • Advances in Radiation Therapy for Primary and Metastatic Adult Soft Tissue Sarcomas.

    abstract::Soft tissue sarcomas (STS) consist of a heterogeneous group of rare malignancies arising from mesenchymal origin. While surgical resection is the primary treatment for STS, the use of radiotherapy (RT) as an adjunctive modality has been shown to improve oncologic outcomes. Technologic improvements, such as image guida...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Blumenfeld P,Sen N,Abrams R,Wang D

    更新日期:2016-06-01 00:00:00

  • Is cancer care best at high-volume providers?

    abstract::For a variety of medical conditions and procedures, a higher volume-better outcome relationship has been hypothesized for over 25 years. An extensive, consistent body of literature supports a relationship between hospital volume and short-term outcomes for cancers treated with technologically complex surgical procedur...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Hillner BE

    更新日期:2001-09-01 00:00:00

  • Endothelin receptor antagonists: rationale, clinical development, and role in prostate cancer therapeutics.

    abstract::The endothelins (ETs), which include ET-1, ET-2, ET-3, and their receptors ET-A and ET-B, play a major role in tumor growth, proliferation, apoptosis, angiogenesis, and bone metastasis. Atrasentan is a novel and selective inhibitor of ET-1 and ET-A. In vitro and in vivo data show that this oral agent is capable of inh...

    journal_title:Current oncology reports

    pub_type: 杂志文章


    authors: Thakkar SG,Choueiri TK,Garcia JA

    更新日期:2006-03-01 00:00:00

  • High-risk non-melanoma skin cancer of the head and neck.

    abstract::High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction. Management of these tumors demands awareness of the characteristics contributing to their recurrence. Recent studies e...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Lai SY,Weber RS

    更新日期:2005-03-01 00:00:00

  • Screening and early detection of skin cancer.

    abstract::Skin cancer is the most common type of cancer in the United States. US incidence of malignant melanoma is increasing faster than any other type of cancer. To minimize increasing morbidity and mortality rates, it is imperative that appropriate screening and early detection of skin cancer become more widespread. All phy...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Linden KG

    更新日期:2004-11-01 00:00:00

  • Postmastectomy radiation therapy.

    abstract::Many women undergo mastectomy as treatment of their breast cancer either because of personal preference or because of tumor-related factors making mastectomy the preferred surgical option. The use of postmastectomy radiation therapy has been shown to decrease the risk of local recurrence and in some cases improve over...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Lyons JA,Sherertz T

    更新日期:2014-01-01 00:00:00

  • Palliative Care in Lung Cancer: When to Start.

    abstract:PURPOSE OF REVIEW:Despite recent advances in the care of patients with advanced non-small cell lung cancer (NSCLC), significant morbidity and mortality remains. Symptoms caused by the cancer and its treatments can be profoundly debilitating. Palliative care aims to reduce this burden. In this review, we discuss the def...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Bhattacharya P,Dessain SK,Evans TL

    更新日期:2018-11-09 00:00:00

  • Toward a Risk-Tailored Therapeutic Policy in Mantle Cell Lymphoma.

    abstract:PURPOSE OF REVIEW:Mantle cell lymphoma (MCL) prognosis is strictly related to the characteristics of the disease, which can range from very indolent cases to highly aggressive and refractory ones. Here we will review the current knowledge on MCL biomarkers. RECENT FINDINGS:Biomarker-informed diagnosis is essential for...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Condoluci A,Rossi D,Zucca E,Cavalli F

    更新日期:2018-08-22 00:00:00

  • Opioids and Chronic Pain: Where Is the Balance?

    abstract::Chronic opioid therapy (defined as greater than 3 months on opioids) is a common practice for those with non-cancer pain, cancer survivors with treatment-related pain, and individuals with cancer undergoing disease-modifying therapy with a survival that can be for a year or more. Recent studies have found unique long-...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Davis MP,Mehta Z

    更新日期:2016-12-01 00:00:00

  • The Management of rNPC: Salvage Surgery vs. Re-irradiation.

    abstract:PURPOSE OF REVIEW:Treatment failure, in the form of either persistence or local recurrence, occurs in 10 to 30% of nasopharyngeal carcinoma patients after initial radiotherapy (RT). Early detection of persistent or recurrent disease aids in the recognition of tumors that can be candidates for salvage nasophayngectomy o...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Hao CY,Hao SP

    更新日期:2020-07-09 00:00:00

  • Immune Checkpoint Inhibitor Toxicity.

    abstract:PURPOSE OF REVIEW:Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Palmieri DJ,Carlino MS

    更新日期:2018-07-31 00:00:00

  • Gastric carcinoma.

    abstract::Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Phan AT,Ajani JA

    更新日期:2004-05-01 00:00:00

  • Treatment Strategy for Distant Synchronous Metastatic Head and Neck Squamous Cell Carcinoma.

    abstract:PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Tang E,Lahmi L,Meillan N,Pietta G,Albert S,Maingon P

    更新日期:2019-11-14 00:00:00

  • Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications.

    abstract:PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Hosein AN,Beg MS

    更新日期:2018-05-11 00:00:00

  • Communicating with Adolescents and Young Adults about Cancer-Associated Weight Loss.

    abstract:PURPOSE OF REVIEW:Over the past two decades, advances have been made in understanding the pathophysiology of cancer-associated weight loss, termed "cachexia." To date, there is no proven effective intervention to completely reverse cachexia and there are no approved drug therapies to treat it. This paper will review re...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Reid J,McKeaveney C,Martin P

    更新日期:2019-02-04 00:00:00

  • Recent advances in the management of gastrointestinal stromal tumors.

    abstract::Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: von Mehren M

    更新日期:2003-07-01 00:00:00

  • Surgical Management of Lung Cancer: History, Evolution, and Modern Advances.

    abstract:PURPOSE OF REVIEW:Although surgery for lung cancer was not common before the early twentieth century, it has enjoyed remarkable progress since then both in type of resection and technical approach. This has been coupled with significant technological advances. Here, we will review the history and evolution of this rela...

    journal_title:Current oncology reports

    pub_type: 历史文章,杂志文章,评审


    authors: Abbas AE

    更新日期:2018-11-13 00:00:00

  • The role of adjuvant monoclonal antibody therapy for breast cancer: rationale and new studies.

    abstract::HER2 is a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases and is involved in the growth, invasion, metastasis, and prognosis of breast cancer. The rationale for prospective trials evaluating the role of anti-HER2 monoclonal antibody therapy for patients with high-risk HER2-positive res...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Perez EA

    更新日期:2001-11-01 00:00:00

  • Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base.

    abstract::Chordomas and chondrosarcomas of the skull base are rare, indolent tumors with a natural history of locally invading their surroundings. Safe, maximal resection is the mainstay of treatment, followed by adjuvant radiation therapy. Even with multimodality therapy, local recurrence remains the most common failure patter...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Nguyen QN,Chang EL

    更新日期:2008-07-01 00:00:00

  • Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy.

    abstract:PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Gentzler RD,Riley DO,Martin LW

    更新日期:2020-08-15 00:00:00

  • Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia.

    abstract::Options for treatment of poor-prognosis or relapsed acute myeloid leukemia (AML) remain limited. Gemtuzumab ozogamicin (Mylotarg, Wyeth-Ayerst, Philadelphia, PA) is an immunoconjugate composed of recombinant humanized murine anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent. Phase II trials have sho...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Stadtmauer EA

    更新日期:2002-09-01 00:00:00

  • Overview of electronic data sharing: why, how, and impact.

    abstract::Electronic data sharing is a critical, but underappreciated, requirement for modern medical informatics systems. This capability is facilitated by acquisition of structured clinical data, but optimized only if this data is stored and transmitted using standardized representations. Most electronic medical record and cl...

    journal_title:Current oncology reports

    pub_type: 杂志文章


    authors: Jones RB,Reeves D,Martinez CS

    更新日期:2012-12-01 00:00:00

  • Risk assessment models to estimate cancer probabilities.

    abstract::Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Johnson CM,Smolenski D

    更新日期:2007-11-01 00:00:00

  • Novel agents in mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma, comprising approximately 6-8% of all non-Hodgkin lymphomas. MCL is biologically and clinically heterogeneous, and there is no standard treatment for MCL. Although untreated MCL often responds well to frontline combination chemotherapy, relapsed, re...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Kumar A

    更新日期:2015-08-01 00:00:00

  • Lymphatic mapping and sentinel node detection in gynecologic malignancies of the lower genital tract.

    abstract::The utility of lymphatic mapping and sentinel lymph node biopsy in malignancies of the female lower genital tract-- vulvar, vaginal, and cervical cancers--is being explored in multiple centers internationally. For patients with these tumors, lymphatic mapping with sentinel lymph node biopsy holds the promise of increa...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Frumovitz M,Ramirez PT,Levenback C

    更新日期:2005-11-01 00:00:00

  • Particle Radiation Therapy for Gastrointestinal Cancers.

    abstract::Particle irradiation of cancerous disease has gained great traction in recent years. The ability for particle therapy centers to deliver radiation with a highly conformal dose distribution while maintaining minimal exit or excess dose delivered to normal tissue, coupled with various biological advantages particularly ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Shinoto M,Ebner DK,Yamada S

    更新日期:2016-03-01 00:00:00

  • New Hypofractionation Radiation Strategies for Glioblastoma.

    abstract:PURPOSE OF REVIEW:Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of less than 2 years despite the standard of care treatment of 6 weeks of chemoradiotherapy. We review the data investigating hypofractionated radiotherapy (HFRT) in the treatment of newly diagnosed ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Azoulay M,Shah J,Pollom E,Soltys SG

    更新日期:2017-09-01 00:00:00

  • Cardioprotective Strategies to Prevent Cancer Treatment-Related Cardiovascular Toxicity: a Review.

    abstract:PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Upshaw JN

    更新日期:2020-06-20 00:00:00

  • Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.

    abstract::Cyclin-dependent kinases (CDKs) and their related pathways represent some of the most attractive targets in the development of anticancer therapeutics. Among a variety of CDK inhibitors under development, flavopiridol, UCN-01, CYC202, and BMS-387032 are undergoing clinical evaluation based on evidence of preclinical a...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Dai Y,Grant S

    更新日期:2004-03-01 00:00:00

  • Pediatric palliative care.

    abstract::Pediatric medicine is moving toward a greater appreciation that the delivery of quality medical care involves a partnership including the health care team, the child, and the family. Pediatric medicine now emphasizes the importance of information exchange among these groups. This paper discusses two models for communi...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Weidner NJ

    更新日期:2007-11-01 00:00:00