Abstract:
:Options for treatment of poor-prognosis or relapsed acute myeloid leukemia (AML) remain limited. Gemtuzumab ozogamicin (Mylotarg, Wyeth-Ayerst, Philadelphia, PA) is an immunoconjugate composed of recombinant humanized murine anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent. Phase II trials have shown the efficacy of gemtuzumab ozogamicin in the treatment of relapsed AML. Trials exploring this agent in other CD33+ hematologic malignancies and in combination with other agents for AML are ongoing. Gemtuzumab ozogamicin is associated with acceptable toxicity as a single agent. However, the incidence of veno-occlusive disease of the liver remains a concern when this agent is used in combination with chemotherapy or in the context of hematopoietic stem cell transplant.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Stadtmauer EAdoi
10.1007/s11912-002-0030-2keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
375-80issue
5eissn
1523-3790issn
1534-6269journal_volume
4pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Standard treatment for early-stage squamous cell cancer of the anal canal (SCCA) includes concurrent chemotherapy and radiation to achieve curative intent. Treatment options are limited, however, especially with locoregional disease relapse occurring in 20-30% of patients and about 10-30% of patients ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00946-3
更新日期:2020-07-11 00:00:00
abstract:PURPOSE OF REVIEW:Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancemen...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0639-9
更新日期:2017-10-28 00:00:00
abstract::The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of me...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0065-2
更新日期:2005-09-01 00:00:00
abstract::Epidemiologic studies supported by molecular technology have provided sufficient evidence of the causal role of some human papillomavirus (HPV) infections in the development of cervical cancer. The finding is consistent universally, and HPV has been proposed as the first identified necessary cause of cervical cancer. ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-002-0079-y
更新日期:2002-03-01 00:00:00
abstract::Intensity-modulated radiotherapy (IMRT) is the next evolutionary step of three-dimensional conformal radiotherapy (3-DCRT). IMRT plans are generated with computer-optimized nonuniform radiation beam intensities incident on a target or patient. The dose distributions in IMRT show significantly higher conformality compa...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0100-0
更新日期:2003-03-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0068-9
更新日期:2003-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes the long scientific background followed to design guidelines and everyday clinical practice applied to melanoma patients. Surgery is the first option to cure melanoma patients (PTS) at initial diagnosis, since primary cutaneous lesions are usually easily resectable. An excisional...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-019-0843-x
更新日期:2019-12-19 00:00:00
abstract::The utility of lymphatic mapping and sentinel lymph node biopsy in malignancies of the female lower genital tract-- vulvar, vaginal, and cervical cancers--is being explored in multiple centers internationally. For patients with these tumors, lymphatic mapping with sentinel lymph node biopsy holds the promise of increa...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0008-y
更新日期:2005-11-01 00:00:00
abstract::Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-011-0166-z
更新日期:2011-06-01 00:00:00
abstract::The diagnosis of a gynecological malignancy during pregnancy is rare but not uncommon. Cancer treatment during pregnancy is possible, but both maternal and fetal interests need to be respected. Different treatment plans may be justifiable and multidisciplinary treatment is advised. Clinical trials are virtually imposs...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-014-0415-z
更新日期:2014-12-01 00:00:00
abstract::Siltuximab is a chimeric monoclonal antibody targeting interleukin-6 (IL-6), which in the fall of 2014 became the first FDA-approved treatment of the rare disease idiopathic multicentric Castleman's disease (MCD). MCD is a non-clonal lymphoproliferative disorder in which common symptoms include fever, night sweats, we...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-015-0453-1
更新日期:2015-07-01 00:00:00
abstract::New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0073-2
更新日期:2005-05-01 00:00:00
abstract::Soft tissue sarcomas (STS) consist of a heterogeneous group of rare malignancies arising from mesenchymal origin. While surgical resection is the primary treatment for STS, the use of radiotherapy (RT) as an adjunctive modality has been shown to improve oncologic outcomes. Technologic improvements, such as image guida...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-016-0523-z
更新日期:2016-06-01 00:00:00
abstract::Skin cancer is the most common type of cancer in the United States. US incidence of malignant melanoma is increasing faster than any other type of cancer. To minimize increasing morbidity and mortality rates, it is imperative that appropriate screening and early detection of skin cancer become more widespread. All phy...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-004-0082-6
更新日期:2004-11-01 00:00:00
abstract::Magnetic resonance imaging (MRI) is the optimal modality for local staging of gynecological tumors. Advances in functional MRI with diffusion-weighted and dynamic contrast-enhanced sequences provide more detailed information regarding tumor cellularity, vascularity, and viability. Fluorodeoxyglucose positron emission ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0640-3
更新日期:2017-11-06 00:00:00
abstract::Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head. It is usually a large B-cell non-Hodgkin's lymphoma. PIOL typically presents as a vitritis that is unresponsive to corticosteroid t...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0029-6
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies and future strategies. RECENT FINDINGS:The number of PD-1/PD-L1...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00928-5
更新日期:2020-06-12 00:00:00
abstract::Management of tumors of the salivary glands requires a detailed understanding of the anatomy and pathologic processes affecting these glands. Salivary glands give rise to benign and malignant neoplasms and are affected by a variety of systemic diseases. CT remains the most common primary imaging study; magnetic resona...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0011-6
更新日期:2007-03-01 00:00:00
abstract::Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-013-0315-7
更新日期:2013-06-01 00:00:00
abstract:PURPOSE REVIEW:B cell signaling agents, including ibrutinib, idelalisib, and the BCL-2 inhibitor venetoclax have become an integral part of therapy for patients with non-Hodgkin's lymphomas. The toxicity profiles of these medications is distinct from chemoimmunotherapy. Here, we will review the mechanism of action of t...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0694-x
更新日期:2018-04-11 00:00:00
abstract::The evolution of our ability to diagnose and classify lymphomas in an increasingly refined manner has paralleled the development of novel technologic approaches, with contemporary practice dependent upon the harnessing of a plethora of data that include microscopic, immunophenotypic, and genetic information. Although ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-004-0063-9
更新日期:2004-09-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/BF02951428
更新日期:2007-01-01 00:00:00
abstract::Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-006-0070-0
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Advanced urothelial carcinoma (aUC) has long been treated preferably with cisplatin-based chemotherapy, but many patients are cisplatin-ineligible whereas for those who progress on a platinum-based regimen treatment options are limited. We review key recent data regarding immune checkpoint inhibitors ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0693-y
更新日期:2018-04-11 00:00:00
abstract::Mutations in the cancer susceptibility genes BRCA1 and BRCA2 are associated with significantly increased risks of breast and ovarian cancer. Fortunately, effective strategies are available to reduce these risks, including genetic testing, which is an important consideration in determining management of patients with a...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-008-0008-9
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Medical decisions concerning active surveillance are complex, especially when evidence on superiority of one of the treatments is lacking. Decision aids have been developed to facilitate shared decision-making on whether to pursue an active surveillance strategy. However, it is unclear how these decis...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00962-3
更新日期:2020-07-28 00:00:00
abstract::With the emergence of telemedicine as a routine form of care in various venues, the opportunities to use technology to care for the most vulnerable, most ill cancer patients are extremely appealing. Increasingly, evidence supports early integration of palliative care with standard oncologic care, supported by recent N...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0600-y
更新日期:2017-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Improved management of infectious complications of acute myeloid leukemia (AML) has contributed substantially to the success of care over the past half century. An important approach to reducing infectious complications during the induction period of chemotherapy involves the use of prophylactic antib...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0574-9
更新日期:2017-03-01 00:00:00
abstract::The number of patients given neoadjuvant chemotherapy (NAC) followed by fertility-sparing surgery in cervical cancer is still scarce. Only a few centres perform these procedures, and thus, such procedures remain largely in the experimental stage. Patients that do not fulfil the criteria for standard fertility-sparing ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-015-0446-0
更新日期:2015-01-01 00:00:00
abstract::Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-004-0049-7
更新日期:2004-05-01 00:00:00