Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia.

Abstract:

:Options for treatment of poor-prognosis or relapsed acute myeloid leukemia (AML) remain limited. Gemtuzumab ozogamicin (Mylotarg, Wyeth-Ayerst, Philadelphia, PA) is an immunoconjugate composed of recombinant humanized murine anti-CD33 antibody linked to calicheamicin, a potent cytotoxic agent. Phase II trials have shown the efficacy of gemtuzumab ozogamicin in the treatment of relapsed AML. Trials exploring this agent in other CD33+ hematologic malignancies and in combination with other agents for AML are ongoing. Gemtuzumab ozogamicin is associated with acceptable toxicity as a single agent. However, the incidence of veno-occlusive disease of the liver remains a concern when this agent is used in combination with chemotherapy or in the context of hematopoietic stem cell transplant.

journal_name

Curr Oncol Rep

journal_title

Current oncology reports

authors

Stadtmauer EA

doi

10.1007/s11912-002-0030-2

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

375-80

issue

5

eissn

1523-3790

issn

1534-6269

journal_volume

4

pub_type

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