Abstract:
:Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With the use of intensive multiagent chemotherapy, non-Hodgkin's lymphomas are now among the most successfully treated cancers in the pediatric population. Future goals of therapy include reduction of treatment duration for early-stage patients and identification of novel targets and therapeutics for advanced-stage patients.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Shukla NN,Trippett TMdoi
10.1007/s11912-006-0062-0subject
Has Abstractpub_date
2006-09-01 00:00:00pages
387-94issue
5eissn
1523-3790issn
1534-6269journal_volume
8pub_type
杂志文章,评审abstract::Cyclin-dependent kinases (CDKs) and their related pathways represent some of the most attractive targets in the development of anticancer therapeutics. Among a variety of CDK inhibitors under development, flavopiridol, UCN-01, CYC202, and BMS-387032 are undergoing clinical evaluation based on evidence of preclinical a...
journal_title:Current oncology reports
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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abstract::This review briefly summarizes the results of previous systemic (chemotherapy) and local (surgery and radiotherapy) treatment attempted to date for malignant mesothelioma. The prospects for newer modalities, ie molecular and biologic therapies, are also highlighted, including results of both preclinical and early clin...
journal_title:Current oncology reports
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0639-9
更新日期:2017-10-28 00:00:00
abstract::Intensity-modulated radiotherapy (IMRT) is the next evolutionary step of three-dimensional conformal radiotherapy (3-DCRT). IMRT plans are generated with computer-optimized nonuniform radiation beam intensities incident on a target or patient. The dose distributions in IMRT show significantly higher conformality compa...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0100-0
更新日期:2003-03-01 00:00:00
abstract::Osteoporosis is a disease that causes substantial morbidity and mortality for which preventive therapy is available. Women with breast cancer are at increased risk for osteoporosis for several reasons, including premature ovarian failure as a result of treatment, direct effects of chemotherapy, and effects of the brea...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0086-7
更新日期:2003-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to sum up the state of the art of urachal carcinoma (UC) in order to easily guide clinicians. RECENT FINDINGS:UC is a rare and aggressive disease with consequent few data about diagnosis and treatment. Dates are mainly based on retrospective trial and case reports with limit...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2020-01-27 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0018-3
更新日期:2001-03-01 00:00:00
abstract::Chemotherapy was traditionally perceived to be ineffective for prostate cancer and was only administered to patients with symptomatic hormone-refractory disease. Although previous reviews have confirmed this belief, recent studies have demonstrated significant antitumor activity with chemotherapy regimens. This articl...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0114-7
更新日期:2003-05-01 00:00:00
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journal_title:Current oncology reports
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更新日期:2002-09-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,收录出版,评审
doi:10.1007/s11912-005-0054-5
更新日期:2005-07-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0073-2
更新日期:2005-05-01 00:00:00
abstract::Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-019-0856-5
更新日期:2019-11-14 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0680-3
更新日期:2018-04-02 00:00:00
abstract::Treatment of Hodgkin's disease (HD) is strictly dependent on stage. Historically, early-stage HD included the limited stages I, II, and IIIA (according to the Cotswolds modification of the Ann Arbor classsification), whereas advanced HD included stage III with B symptoms and stage IV. It was then observed that early-s...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0062-z
更新日期:2001-05-01 00:00:00
abstract::Electronic data sharing is a critical, but underappreciated, requirement for modern medical informatics systems. This capability is facilitated by acquisition of structured clinical data, but optimized only if this data is stored and transmitted using standardized representations. Most electronic medical record and cl...
journal_title:Current oncology reports
pub_type: 杂志文章
doi:10.1007/s11912-012-0271-7
更新日期:2012-12-01 00:00:00
abstract::The evolution of our ability to diagnose and classify lymphomas in an increasingly refined manner has paralleled the development of novel technologic approaches, with contemporary practice dependent upon the harnessing of a plethora of data that include microscopic, immunophenotypic, and genetic information. Although ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-004-0063-9
更新日期:2004-09-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
abstract::Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected. Evidence to support this is now emerging as the Not...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-008-0071-2
更新日期:2008-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2017-11-06 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
abstract::Anaplastic oligodendrogliomas are rare primary brain tumors. However, they respond more effectively to treatment and have a better prognosis than commoner varieties. About 25 year ago, reports emerged that oligodendrogliomas can respond robustly and durably to chemotherapy with procarbazine, lomustine (CCNU), and vinc...
journal_title:Current oncology reports
pub_type: 杂志文章
doi:10.1007/s11912-012-0281-5
更新日期:2013-02-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-010-0089-0
更新日期:2010-05-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-008-0032-9
更新日期:2008-05-01 00:00:00
abstract::Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-006-0070-0
更新日期:2006-11-01 00:00:00
abstract::High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of the ovarian cancer deaths, but over the last years little improvement in overall survival has been achieved. HGSOC is a molecularly and clinically heterogeneous disease. At genomic level, it represents a C-class malignancy having frequent gene lo...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-016-0526-9
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0592-7
更新日期:2017-05-01 00:00:00
abstract::With the emergence of telemedicine as a routine form of care in various venues, the opportunities to use technology to care for the most vulnerable, most ill cancer patients are extremely appealing. Increasingly, evidence supports early integration of palliative care with standard oncologic care, supported by recent N...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0600-y
更新日期:2017-06-01 00:00:00