Abstract:
:Magnetic resonance imaging (MRI) is the optimal modality for local staging of gynecological tumors. Advances in functional MRI with diffusion-weighted and dynamic contrast-enhanced sequences provide more detailed information regarding tumor cellularity, vascularity, and viability. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) now has an established role in imaging for gynecological cancers, particularly staging of locally advanced cervical cancers and pre-salvage exenterative therapy in relapsed gynecologic tumors. Novel PET tracers, targeting other aspects of tumor biology, are being evaluated although none are currently in routine clinical use. New PET/MR scanners have the potential to combine the strengths of both modalities in one sitting. This review covers advances in gynecologic imaging concentrating on cervical, endometrial, and ovarian cancers.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Khan SR,Arshad M,Wallitt K,Stewart V,Bharwani N,Barwick TDdoi
10.1007/s11912-017-0640-3subject
Has Abstractpub_date
2017-11-06 00:00:00pages
85issue
12eissn
1523-3790issn
1534-6269pii
10.1007/s11912-017-0640-3journal_volume
19pub_type
杂志文章,评审abstract::Accurate, reproducible criteria for determining tumor response and progression after therapy are critical for optimal patient care and effective evaluation of novel therapeutic agents. Currently, the most widely used criteria for determining treatment response in gliomas is based on two-dimensional tumor measurements ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-009-0078-3
更新日期:2010-01-01 00:00:00
abstract::Overall survival for patients with squamous cell carcinoma of the head and neck (SCCHN) has not improved appreciably over the past few decades. Because standard treatments have not controlled this disease with sufficiently high success rates, novel therapeutic approaches, such as immunotherapy, are under investigation...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-008-0025-8
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0699-5
更新日期:2018-05-11 00:00:00
abstract:PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-019-0845-8
更新日期:2019-11-07 00:00:00
abstract::Health-related quality of life (QOL) outcomes are frequently used by clinicians, patients, and researchers for assessing the effectiveness of an intervention. Small differences in QOL may be statistically significant but their clinical relevance remains undefined. The smallest changes in QOL scores of the anterior sku...
journal_title:Current oncology reports
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11912-012-0222-3
更新日期:2012-04-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has res...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/BF02951428
更新日期:2007-01-01 00:00:00
abstract::Management of tumors of the salivary glands requires a detailed understanding of the anatomy and pathologic processes affecting these glands. Salivary glands give rise to benign and malignant neoplasms and are affected by a variety of systemic diseases. CT remains the most common primary imaging study; magnetic resona...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0011-6
更新日期:2007-03-01 00:00:00
abstract::The RAS-RAF-MEK-ERK pathway is considered to be the most important signal transduction pathway in melanoma, and alterations in this pathway via various genetic mutations, such as BRAF and NRAS mutations, are known to be important drivers of melanomagenesis. As MEK is an essential intermediary kinase protein within thi...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-013-0336-2
更新日期:2013-10-01 00:00:00
abstract::High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction. Management of these tumors demands awareness of the characteristics contributing to their recurrence. Recent studies e...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0042-9
更新日期:2005-03-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-006-0016-6
更新日期:2006-05-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0718-6
更新日期:2018-07-31 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-012-0249-5
更新日期:2012-10-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-000-0006-z
更新日期:2000-01-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-0878-z
更新日期:2020-01-27 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-000-0108-7
更新日期:2000-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-011-0191-y
更新日期:2011-12-01 00:00:00
abstract::Particle irradiation of cancerous disease has gained great traction in recent years. The ability for particle therapy centers to deliver radiation with a highly conformal dose distribution while maintaining minimal exit or excess dose delivered to normal tissue, coupled with various biological advantages particularly ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-016-0499-8
更新日期:2016-03-01 00:00:00
abstract::Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1A1, CYP2D6, and CYP...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-000-0075-z
更新日期:2000-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate stan...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00951-6
更新日期:2020-07-10 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0056-6
更新日期:2007-09-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-0900-5
更新日期:2020-03-13 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0639-9
更新日期:2017-10-28 00:00:00
abstract:PURPOSE OF REVIEW:Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of less than 2 years despite the standard of care treatment of 6 weeks of chemoradiotherapy. We review the data investigating hypofractionated radiotherapy (HFRT) in the treatment of newly diagnosed ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0616-3
更新日期:2017-09-01 00:00:00
abstract::Notch signaling plays crucial roles in many developmental pathways, with Notch mutations linked to several developmental disorders. Because many pediatric malignancies arise from dysregulated development, roles for Notch signaling in these cancers are to be expected. Evidence to support this is now emerging as the Not...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-008-0071-2
更新日期:2008-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0062-z
更新日期:2001-05-01 00:00:00
abstract::Hypogonadism is common throughout the illness trajectory of patients with cancer. About two thirds of male patients with advanced cancer have hypothalamic-pituitary-gonadal dysfunction and low testosterone levels. Chronic inflammation, comorbidities, cachexia, chemotherapy, and medications such as opioids, megestrol a...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-014-0378-0
更新日期:2014-04-01 00:00:00
abstract::Proton beam radiation therapy (PBRT) has unique physical properties (e.g., Bragg Peak) that limit the amount of normal tissue irradiated in the head and neck region while maximizing the radiation delivered to the tumor. Radiation therapy is commonly used in both the primary and adjuvant setting for many head and neck ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-010-0089-0
更新日期:2010-05-01 00:00:00
abstract::Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0071-7
更新日期:2007-11-01 00:00:00
abstract::Recent advances in molecular biology have enhanced our understanding of the pathogenesis of brain tumors, particularly in children. The use of molecular diagnostic tools is quickly becoming a standard component in the diagnosis and classification of brain tumors in children, in addition to providing insight leading to...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-006-0070-0
更新日期:2006-11-01 00:00:00
abstract::The establishment of the Intergroup Rhabdomyosarcoma Study (IRS) Committee in 1972 by three extant American pediatric cooperative groups initiated five generations of studies in the multidisciplinary treatment of soft-tissue sarcomas. Taking the lead from the use of vincristine, actinomycin-D, and cyclophosphamide (VA...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0012-z
更新日期:2003-11-01 00:00:00