Abstract:
PURPOSE OF REVIEW:Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancements, such as image-guided radiation therapy (IGRT), intensity-modulated radiation therapy (IMRT), particle therapy, and stereotactic radiation therapy (SRT), are attractive for skull base reirradiation. RECENT FINDINGS:Although limited by their retrospective nature and heterogeneous patient populations, several studies have demonstrated that reirradiation with these highly conformal techniques is feasible. Compared to IMRT or particle therapy reirradiation, SRT reirradiation appears promising with lower toxicity and increased convenience. Here, we provide thorough explanations for each technology and summarize the most relevant and recent studies, with particular attention to efficacy and toxicity. Skull base reirradiation using these extremely conformal therapy techniques requires meticulous treatment planning and should be delivered by experienced teams.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Ho JC,Phan Jdoi
10.1007/s11912-017-0639-9subject
Has Abstractpub_date
2017-10-28 00:00:00pages
82issue
12eissn
1523-3790issn
1534-6269pii
10.1007/s11912-017-0639-9journal_volume
19pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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journal_title:Current oncology reports
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journal_title:Current oncology reports
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pub_type: 杂志文章,评审
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