Update on treatment advances in combined-modality therapy for anal and rectal carcinomas.

abstract：:Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1A1, CYP2D6, and CYP...

journal_title：Current oncology reports

authors： Clapper ML

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades, advances have been made in understanding the pathophysiology of cancer-associated weight loss, termed "cachexia." To date, there is no proven effective intervention to completely reverse cachexia and there are no approved drug therapies to treat it. This paper will review re...

journal_title：Current oncology reports

authors： Reid J,McKeaveney C,Martin P

更新日期：2019-02-04 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

journal_title：Current oncology reports

authors： Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

更新日期：2018-04-10 00:00:00

abstract：:Most patients with chronic lymphocytic leukemia are diagnosed at an early stage, when traditional staging systems fail to distinguish those with an aggressive disease course from those with an excellent prognosis. This failure underscores the need for better prognostic markers. Although many markers have been explored...

journal_title：Current oncology reports

authors： Jain N,Lamanna N

更新日期：2009-09-01 00:00:00

abstract：:Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, ei...

journal_title：Current oncology reports

authors： Howell SJ,Shalet SM

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors (ICI) are only effective in a subset of patients. Here, we will review the rationale and data supporting the combination of PD-1 pathway inhibition with recombinant cytokines and neoantigen-based cancer vaccines that can potentially increase the number of patients who will...

journal_title：Current oncology reports

authors： Barroso-Sousa R,Ott PA

更新日期：2018-11-15 00:00:00

abstract：:Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor...

journal_title：Current oncology reports

authors： Pawlik TM,Choti MA

更新日期：2007-05-01 00:00:00

abstract：:Results of treatment for patients with non-Hodgkin's lymphomas have significantly improved over the last decade, especially following the discovery that anti-CD20 antibody therapy can significantly change the outlook for patients with both aggressive and indolent lymphomas. Although investigators have previously attem...

journal_title：Current oncology reports

authors： Hagemeister FB

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...

journal_title：Current oncology reports

authors： Filippi AR,Levis M,Parikh R,Hoppe B

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Medical decisions concerning active surveillance are complex, especially when evidence on superiority of one of the treatments is lacking. Decision aids have been developed to facilitate shared decision-making on whether to pursue an active surveillance strategy. However, it is unclear how these decis...

journal_title：Current oncology reports

authors： Collée GE,van der Wilk BJ,van Lanschot JJB,Busschbach JJ,Timmermans L,Lagarde SM,Kranenburg LW

更新日期：2020-07-28 00:00:00

abstract：PURPOSE OF REVIEW:Although surgery for lung cancer was not common before the early twentieth century, it has enjoyed remarkable progress since then both in type of resection and technical approach. This has been coupled with significant technological advances. Here, we will review the history and evolution of this rela...

journal_title：Current oncology reports

authors： Abbas AE

更新日期：2018-11-13 00:00:00

abstract：:Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...

journal_title：Current oncology reports

authors： Bradshaw M,Mansfield A,Peikert T

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Anaplastic lymphoma kinase (ALK) rearrangements represent a seldom event in non-small cell lung cancer (NSCLC). Given the oncogene alteration, ALK targeting represents the main therapeutic strategy. Here, we review evidence regarding ALK inhibitors (ALKi): clinical activity, safety profiles, financial...

journal_title：Current oncology reports

authors： Tabbò F,Passiglia F,Novello S

更新日期：2021-01-02 00:00:00

abstract：PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...

journal_title：Current oncology reports

authors： Upshaw JN

更新日期：2020-06-20 00:00:00

abstract：:Malnutrition is common in patients with cancer and is associated with a variety of negative outcomes. These can include reduced treatment tolerance and worsened cancer prognosis. Various aspects of aging, including sensory, physical, or psychosocial changes, place older patients at a particularly high risk for malnutr...

journal_title：Current oncology reports

authors： Jain R,Dotan E

更新日期：2017-09-07 00:00:00

abstract：:The treatment of non-Hodgkin lymphoma (NHL) has changed dramatically since the introduction of rituximab, a monoclonal antibody that binds to the B-cell transmembrane protein CD20 and causes lysis of the lymphoma cells. Since then, a number of additional antibodies have been tested against other B-cell targets, result...

journal_title：Current oncology reports

authors： Sikder MA,Friedberg JW

更新日期：2008-09-01 00:00:00

abstract：:High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of the ovarian cancer deaths, but over the last years little improvement in overall survival has been achieved. HGSOC is a molecularly and clinically heterogeneous disease. At genomic level, it represents a C-class malignancy having frequent gene lo...

journal_title：Current oncology reports

authors： Mittempergher L

更新日期：2016-07-01 00:00:00

abstract：:The RAS-RAF-MEK-ERK pathway is considered to be the most important signal transduction pathway in melanoma, and alterations in this pathway via various genetic mutations, such as BRAF and NRAS mutations, are known to be important drivers of melanomagenesis. As MEK is an essential intermediary kinase protein within thi...

journal_title：Current oncology reports

authors： Salama AK,Kim KB

更新日期：2013-10-01 00:00:00

abstract：:Lung cancer is the most common cause of cancer death worldwide. The overall 5-year survival rate remains disappointing at 14% or less. Several clinician- and community-based interventions show promise for reducing lung cancer incidence through prevention and smoking cessation. However, long-term heavy smokers retain a...

journal_title：Current oncology reports

authors： McWilliams A,Lam S

更新日期：2002-11-01 00:00:00

abstract：:Brain metastases seem to be an almost inevitable complication in patients with metastatic melanoma. Except for the rare patients who can undergo successful surgical resection of brain metastases, current management strategies do not appear adequate and result in a poor outcome (median survival, 2-4 months). In recent ...

journal_title：Current oncology reports

authors： Majer M,Samlowski WE

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...

journal_title：Current oncology reports

authors： Tang E,Lahmi L,Meillan N,Pietta G,Albert S,Maingon P

更新日期：2019-11-14 00:00:00

abstract：:Accurate, reproducible criteria for determining tumor response and progression after therapy are critical for optimal patient care and effective evaluation of novel therapeutic agents. Currently, the most widely used criteria for determining treatment response in gliomas is based on two-dimensional tumor measurements ...

journal_title：Current oncology reports

authors： Wen PY,Norden AD,Drappatz J,Quant E

更新日期：2010-01-01 00:00:00

abstract：:Epidemiologic studies supported by molecular technology have provided sufficient evidence of the causal role of some human papillomavirus (HPV) infections in the development of cervical cancer. The finding is consistent universally, and HPV has been proposed as the first identified necessary cause of cervical cancer. ...

journal_title：Current oncology reports

authors： Bosch FX,de Sanjosé S

更新日期：2002-03-01 00:00:00

abstract：:Postmastectomy radiotherapy continues to be one of the most controversial issues in breast radiotherapy. At the crux of the controversy lies the lack of conclusive studies that specifically address the risk-benefit ratio of postmastectomy radiotherapy for patients at intermediate risk of developing locoregional recurr...

journal_title：Current oncology reports

authors： Sartor CI

更新日期：2006-01-01 00:00:00

abstract：:Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head. It is usually a large B-cell non-Hodgkin's lymphoma. PIOL typically presents as a vitritis that is unresponsive to corticosteroid t...

journal_title：Current oncology reports

authors： Kim SK,Chan CC,Wallace DJ

更新日期：2005-01-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma, comprising approximately 6-8% of all non-Hodgkin lymphomas. MCL is biologically and clinically heterogeneous, and there is no standard treatment for MCL. Although untreated MCL often responds well to frontline combination chemotherapy, relapsed, re...

journal_title：Current oncology reports

authors： Kumar A

更新日期：2015-08-01 00:00:00

abstract：:Most of the experience with second-line chemotherapy for non-small-cell lung cancer (NSCLC) comes from small phase II trials, which have shown disappointing or inconsistent results. The notable exception has been docetaxel, which has been extensively studied as a second-line therapy for NSCLC. On the basis of consiste...

journal_title：Current oncology reports

authors： Fossella FV

更新日期：2000-01-01 00:00:00

abstract：:Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths in American men. Although the use of the prostate-specific antigen (PSA) test for prostate cancer screening since the 1990s has led to increased early diagnoses, the most recent studies are in conflict about the risks and b...

journal_title：Current oncology reports

authors： Cook ED,Nelson AC

更新日期：2011-02-01 00:00:00

abstract：:Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the...

journal_title：Current oncology reports

authors： Ramos JC,Lossos IS

更新日期：2011-10-01 00:00:00

abstract：:The endothelins (ETs), which include ET-1, ET-2, ET-3, and their receptors ET-A and ET-B, play a major role in tumor growth, proliferation, apoptosis, angiogenesis, and bone metastasis. Atrasentan is a novel and selective inhibitor of ET-1 and ET-A. In vitro and in vivo data show that this oral agent is capable of inh...

journal_title：Current oncology reports

authors： Thakkar SG,Choueiri TK,Garcia JA

更新日期：2006-03-01 00:00:00