Abstract：
:Malnutrition is common in patients with cancer and is associated with a variety of negative outcomes. These can include reduced treatment tolerance and worsened cancer prognosis. Various aspects of aging, including sensory, physical, or psychosocial changes, place older patients at a particularly high risk for malnutrition, and these geriatric factors must be identified early and addressed. Despite the lack of available evidence on the optimal nutritional interventions for older adults with cancer, the oncologist must be prepared to address the common nutritional concerns that arise in both advanced cancer and survivorship settings. While BMI, weight loss, and serum albumin are commonly used as surrogates of malnutrition, the use of a comprehensive screening tool may promote early identification of disrupted eating patterns and allow for prompt intervention. New digital technologies have also demonstrated promise to improve nutritional assessment capabilities. Use of conventional nutritional support in conjunction with novel nutraceutical and anti-cachexia approaches may enhance the effectiveness of interventions and improve our ability to reverse malnutrition-associated alterations in body composition. Future geriatric-focused nutrition research will be crucial in helping guide our patients and effectively addressing their dietary and lifestyle concerns.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Jain R,Dotan Edoi
10.1007/s11912-017-0630-5subject
Has Abstractpub_date
2017-09-07 00:00:00pages
71issue
11eissn
1523-3790issn
1534-6269pii
10.1007/s11912-017-0630-5journal_volume
19pub_type
杂志文章,评审abstract：:There has been much development in the field of targeted therapy for melanoma stemming from efforts to decrease treatment-related toxicities and enhance specific cytotoxicity. This review focuses on three modalities of targeted melanoma therapy based on the biology of the targeting mechanism. The first of these modali...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-001-0088-2
更新日期：2001-07-01 00:00:00
abstract：:Chronic opioid therapy (defined as greater than 3 months on opioids) is a common practice for those with non-cancer pain, cancer survivors with treatment-related pain, and individuals with cancer undergoing disease-modifying therapy with a survival that can be for a year or more. Recent studies have found unique long-...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-016-0558-1
更新日期：2016-12-01 00:00:00
abstract：PURPOSE REVIEW:B cell signaling agents, including ibrutinib, idelalisib, and the BCL-2 inhibitor venetoclax have become an integral part of therapy for patients with non-Hodgkin's lymphomas. The toxicity profiles of these medications is distinct from chemoimmunotherapy. Here, we will review the mechanism of action of t...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0694-x
更新日期：2018-04-11 00:00:00
abstract：:Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil (5-FU) and mitomycin results in high rates of local control and...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-009-0027-1
更新日期：2009-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-002-0006-2
更新日期：2002-07-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-011-0161-4
更新日期：2011-06-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-999-0012-8
更新日期：1999-09-01 00:00:00
abstract：:The RAS-RAF-MEK-ERK pathway is considered to be the most important signal transduction pathway in melanoma, and alterations in this pathway via various genetic mutations, such as BRAF and NRAS mutations, are known to be important drivers of melanomagenesis. As MEK is an essential intermediary kinase protein within thi...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-013-0336-2
更新日期：2013-10-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2007-11-01 00:00:00
abstract：:Neuroblastoma is the most common extracranial tumor of childhood, with about 650 new cases each year in the United States. The clinical course of neuroblastoma is variable and depends on age at diagnosis, staging, histology, and specific genetic abnormalities, such as MYCN oncogene amplification or aberrations of chro...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2009-11-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-00949-0
更新日期：2020-07-09 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-013-0316-6
更新日期：2013-08-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-018-0699-5
更新日期：2018-05-11 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
abstract：:High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of the ovarian cancer deaths, but over the last years little improvement in overall survival has been achieved. HGSOC is a molecularly and clinically heterogeneous disease. At genomic level, it represents a C-class malignancy having frequent gene lo...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-016-0526-9
更新日期：2016-07-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-013-0315-7
更新日期：2013-06-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-000-0075-z
更新日期：2000-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-007-0071-7
更新日期：2007-11-01 00:00:00
abstract：:The topoisomerase I inhibitors such as irinotecan and topotecan are active agents against small-cell lung cancer that are effective in treating not only chemotherapy-naïve tumors but also progressed-stage tumors after treatment with cisplatin-based regimens, because their mechanism of antitumor activity differs from t...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
abstract：PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2020-06-20 00:00:00
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journal_title：Current oncology reports
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
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journal_title：Current oncology reports
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更新日期：2000-03-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2020-01-27 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2008-03-01 00:00:00
abstract：:Osteoporosis is a disease that causes substantial morbidity and mortality for which preventive therapy is available. Women with breast cancer are at increased risk for osteoporosis for several reasons, including premature ovarian failure as a result of treatment, direct effects of chemotherapy, and effects of the brea...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-003-0086-7
更新日期：2003-01-01 00:00:00
abstract：:There is no clear consensus regarding the most effective management of poor responders to neoadjuvant chemotherapy. Intensifying or changing primary systemic treatment has not been shown to offer any benefit. There is a paucity of trials testing the utility of adjuvant chemotherapy in this setting. Adjuvant hormonal t...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-009-0007-5
更新日期：2009-01-01 00:00:00
abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2005-05-01 00:00:00
abstract：PURPOSE OF REVIEW:This review describes the long scientific background followed to design guidelines and everyday clinical practice applied to melanoma patients. Surgery is the first option to cure melanoma patients (PTS) at initial diagnosis, since primary cutaneous lesions are usually easily resectable. An excisional...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-019-0843-x
更新日期：2019-12-19 00:00:00
abstract：PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
doi：10.1007/s11912-020-0900-5
更新日期：2020-03-13 00:00:00
