听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Current Oncology Reports期刊下所有文献
  • Upfront Management of ALK-Rearranged Metastatic Non-small Cell Lung Cancer: One Inhibitor Fits All?

    abstract:PURPOSE OF REVIEW:Anaplastic lymphoma kinase (ALK) rearrangements represent a seldom event in non-small cell lung cancer (NSCLC). Given the oncogene alteration, ALK targeting represents the main therapeutic strategy. Here, we review evidence regarding ALK inhibitors (ALKi): clinical activity, safety profiles, financial...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00989-6

    authors: Tabbò F,Passiglia F,Novello S

    更新日期:2021-01-02 00:00:00

  • Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy.

    abstract:PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00969-w

    authors: Gentzler RD,Riley DO,Martin LW

    更新日期:2020-08-15 00:00:00

  • Interventions that Facilitate Shared Decision-Making in Cancers with Active Surveillance as Treatment Option: a Systematic Review of Literature.

    abstract:PURPOSE OF REVIEW:Medical decisions concerning active surveillance are complex, especially when evidence on superiority of one of the treatments is lacking. Decision aids have been developed to facilitate shared decision-making on whether to pursue an active surveillance strategy. However, it is unclear how these decis...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00962-3

    authors: Collée GE,van der Wilk BJ,van Lanschot JJB,Busschbach JJ,Timmermans L,Lagarde SM,Kranenburg LW

    更新日期:2020-07-28 00:00:00

  • A Review of the Current State of Hospice Care in China.

    abstract:PURPOSE OF REVIEW:This review was undertaken to analyze the main reasons behind the limited development of hospice care in China, and to put forward some suggestions. RECENT FINDINGS:Although the Chinese government has increased its support for hospice care in recent years, however, owing to the lack of education arou...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00959-y

    authors: Ling M,Wang X,Ma Y,Long Y

    更新日期:2020-07-28 00:00:00

  • Immunotherapy in Anal Cancer.

    abstract:PURPOSE OF REVIEW:Standard treatment for early-stage squamous cell cancer of the anal canal (SCCA) includes concurrent chemotherapy and radiation to achieve curative intent. Treatment options are limited, however, especially with locoregional disease relapse occurring in 20-30% of patients and about 10-30% of patients ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00946-3

    authors: Phuong L,Rajdev L

    更新日期:2020-07-11 00:00:00

  • Value and Quality of Care in Head and Neck Oncology.

    abstract:PURPOSE OF REVIEW:The concept of value-based health care (VBHC) was articulated more than a decade ago. However, its clinical implementation remains an on-going process and a particularly demanding one for the domain of head and neck cancer (HNC). These cancers often present with fast growing tumors in functionally and...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00952-5

    authors: Takes RP,Halmos GB,Ridge JA,Bossi P,Merkx MAW,Rinaldo A,Sanabria A,Smeele LE,Mäkitie AA,Ferlito A

    更新日期:2020-07-10 00:00:00

  • Guiding Treatment Choices for Elderly Patients with Glioblastoma by a Comprehensive Geriatric Assessment.

    abstract:PURPOSE OF REVIEW:The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate stan...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00951-6

    authors: Lütgendorf-Caucig C,Freyschlag C,Masel EK,Marosi C

    更新日期:2020-07-10 00:00:00

  • The Management of rNPC: Salvage Surgery vs. Re-irradiation.

    abstract:PURPOSE OF REVIEW:Treatment failure, in the form of either persistence or local recurrence, occurs in 10 to 30% of nasopharyngeal carcinoma patients after initial radiotherapy (RT). Early detection of persistent or recurrent disease aids in the recognition of tumors that can be candidates for salvage nasophayngectomy o...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00949-0

    authors: Hao CY,Hao SP

    更新日期:2020-07-09 00:00:00

  • Cardioprotective Strategies to Prevent Cancer Treatment-Related Cardiovascular Toxicity: a Review.

    abstract:PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00923-w

    authors: Upshaw JN

    更新日期:2020-06-20 00:00:00

  • Spectrum and Clinical Activity of PD-1/PD-L1 Inhibitors: Regulatory Approval and Under Development.

    abstract:PURPOSE OF REVIEW:The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies and future strategies. RECENT FINDINGS:The number of PD-1/PD-L1...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-00928-5

    authors: Oliveira LJC,Gongora ABL,Jardim DLF

    更新日期:2020-06-12 00:00:00

  • Stringent Control of Opioids: Sound Public Health Measures, but a Step Too Far in Palliative Care?

    abstract:PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-0900-5

    authors: Pinkerton R,Mitchell G,Hardy J

    更新日期:2020-03-13 00:00:00

  • Current Understanding of Urachal Adenocarcinoma and Management Strategy.

    abstract:PURPOSE OF REVIEW:The aim of this review is to sum up the state of the art of urachal carcinoma (UC) in order to easily guide clinicians. RECENT FINDINGS:UC is a rare and aggressive disease with consequent few data about diagnosis and treatment. Dates are mainly based on retrospective trial and case reports with limit...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-020-0878-z

    authors: Claps M,Stellato M,Zattarin E,Mennitto A,Sepe P,Guadalupi V,Mennitto R,de Braud FGM,Verzoni E,Procopio G

    更新日期:2020-01-27 00:00:00

  • Primary Melanoma: from History to Actual Debates.

    abstract:PURPOSE OF REVIEW:This review describes the long scientific background followed to design guidelines and everyday clinical practice applied to melanoma patients. Surgery is the first option to cure melanoma patients (PTS) at initial diagnosis, since primary cutaneous lesions are usually easily resectable. An excisional...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-019-0843-x

    authors: Testori AAE,Blankenstein SA,van Akkooi ACJ

    更新日期:2019-12-19 00:00:00

  • Treatment Strategy for Distant Synchronous Metastatic Head and Neck Squamous Cell Carcinoma.

    abstract:PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-019-0856-5

    authors: Tang E,Lahmi L,Meillan N,Pietta G,Albert S,Maingon P

    更新日期:2019-11-14 00:00:00

  • Contemporary Approach to Locally Advanced Oral Cavity Squamous Cell Carcinoma.

    abstract:PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-019-0845-8

    authors: Yao CMKL,Chang EI,Lai SY

    更新日期:2019-11-07 00:00:00

  • New Directions in Vulvar Cancer Pathology.

    abstract:PURPOSE OF REVIEW:The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates. RECENT FINDINGS:There is an increased understanding of subcellular changes in vulvar malignancies. These p...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-019-0833-z

    authors: Williams A,Syed S,Velangi S,Ganesan R

    更新日期:2019-08-15 00:00:00

  • Predicting Life Expectancy for Older Adults with Cancer in Clinical Practice: Implications for Shared Decision-making.

    abstract:PURPOSE OF REVIEW:The calculation of noncancer-specific life expectancy can guide shared decision-making and avoid over- and undertreatment in older adults with cancer. Several factors determine life expectancy, including socio-demographic background, comorbidities, physical performance, and geriatric assessment variab...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-019-0821-3

    authors: Verduzco-Aguirre HC,Gomez-Moreno C,Chavarri-Guerra Y,Soto-Perez-de-Celis E

    更新日期:2019-06-25 00:00:00

  • Correction to: Systemic Therapy of Central Nervous System Metastases of Breast Cancer.

    abstract::The original version of this article, which published in Current Oncology Reports, Volume 21, Issue 6, June 2019, contained an error in addressing the indication for use of neratinib in early stage breast cancer. ...

    journal_title:Current oncology reports

    pub_type: 已发布勘误

    doi:10.1007/s11912-019-0813-3

    authors: Leone JP,Lin NU

    更新日期:2019-05-17 00:00:00

  • Communicating with Adolescents and Young Adults about Cancer-Associated Weight Loss.

    abstract:PURPOSE OF REVIEW:Over the past two decades, advances have been made in understanding the pathophysiology of cancer-associated weight loss, termed "cachexia." To date, there is no proven effective intervention to completely reverse cachexia and there are no approved drug therapies to treat it. This paper will review re...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-019-0765-7

    authors: Reid J,McKeaveney C,Martin P

    更新日期:2019-02-04 00:00:00

  • Transformation of Old Concepts for a New Era of Cancer Immunotherapy: Cytokine Therapy and Cancer Vaccines as Combination Partners of PD1/PD-L1 Inhibitors.

    abstract:PURPOSE OF REVIEW:Immune checkpoint inhibitors (ICI) are only effective in a subset of patients. Here, we will review the rationale and data supporting the combination of PD-1 pathway inhibition with recombinant cytokines and neoantigen-based cancer vaccines that can potentially increase the number of patients who will...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0738-2

    authors: Barroso-Sousa R,Ott PA

    更新日期:2018-11-15 00:00:00

  • Surgical Management of Lung Cancer: History, Evolution, and Modern Advances.

    abstract:PURPOSE OF REVIEW:Although surgery for lung cancer was not common before the early twentieth century, it has enjoyed remarkable progress since then both in type of resection and technical approach. This has been coupled with significant technological advances. Here, we will review the history and evolution of this rela...

    journal_title:Current oncology reports

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s11912-018-0741-7

    authors: Abbas AE

    更新日期:2018-11-13 00:00:00

  • Palliative Care in Lung Cancer: When to Start.

    abstract:PURPOSE OF REVIEW:Despite recent advances in the care of patients with advanced non-small cell lung cancer (NSCLC), significant morbidity and mortality remains. Symptoms caused by the cancer and its treatments can be profoundly debilitating. Palliative care aims to reduce this burden. In this review, we discuss the def...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0731-9

    authors: Bhattacharya P,Dessain SK,Evans TL

    更新日期:2018-11-09 00:00:00

  • Toward a Risk-Tailored Therapeutic Policy in Mantle Cell Lymphoma.

    abstract:PURPOSE OF REVIEW:Mantle cell lymphoma (MCL) prognosis is strictly related to the characteristics of the disease, which can range from very indolent cases to highly aggressive and refractory ones. Here we will review the current knowledge on MCL biomarkers. RECENT FINDINGS:Biomarker-informed diagnosis is essential for...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0728-4

    authors: Condoluci A,Rossi D,Zucca E,Cavalli F

    更新日期:2018-08-22 00:00:00

  • Immune Checkpoint Inhibitor Toxicity.

    abstract:PURPOSE OF REVIEW:Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0718-6

    authors: Palmieri DJ,Carlino MS

    更新日期:2018-07-31 00:00:00

  • Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications.

    abstract:PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0699-5

    authors: Hosein AN,Beg MS

    更新日期:2018-05-11 00:00:00

  • Systemic Therapies for Advanced Squamous Cell Anal Cancer.

    abstract:PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, e...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0698-6

    authors: Sclafani F,Rao S

    更新日期:2018-05-04 00:00:00

  • Monitoring and Management of Toxicities of Novel B Cell Signaling Agents.

    abstract:PURPOSE REVIEW:B cell signaling agents, including ibrutinib, idelalisib, and the BCL-2 inhibitor venetoclax have become an integral part of therapy for patients with non-Hodgkin's lymphomas. The toxicity profiles of these medications is distinct from chemoimmunotherapy. Here, we will review the mechanism of action of t...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0694-x

    authors: Rhodes J,Mato A,Sharman JP

    更新日期:2018-04-11 00:00:00

  • Emerging Role of Immunotherapy in Advanced Urothelial Carcinoma.

    abstract:PURPOSE OF REVIEW:Advanced urothelial carcinoma (aUC) has long been treated preferably with cisplatin-based chemotherapy, but many patients are cisplatin-ineligible whereas for those who progress on a platinum-based regimen treatment options are limited. We review key recent data regarding immune checkpoint inhibitors ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0693-y

    authors: Koshkin VS,Grivas P

    更新日期:2018-04-11 00:00:00

  • Single-Cell RNA-Sequencing in Glioma.

    abstract:PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0673-2

    authors: Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

    更新日期:2018-04-10 00:00:00

  • Targeted Agents in Cervical Cancer: Beyond Bevacizumab.

    abstract::Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates despite correct multidisciplinary management. Metastatic disease implies a poor pr...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0680-3

    authors: Marquina G,Manzano A,Casado A

    更新日期:2018-04-02 00:00:00

  • Using Information Technology in the Assessment and Monitoring of Geriatric Oncology Patients.

    abstract:PURPOSE OF REVIEW:Older adults with cancer have complex medical needs and often experience higher rates of treatment-related toxicities compared to their younger counterparts. The advent of health information technologies can address multiple gaps in the care of this population. We review the role of existing and emerg...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-018-0672-3

    authors: Loh KP,McHugh C,Mohile SG,Mustian K,Flannery M,Klepin H,Schnall R,Culakova E,Ramsdale E

    更新日期:2018-03-06 00:00:00

  • What's New in Imaging for Gynecologic Cancer?

    abstract::Magnetic resonance imaging (MRI) is the optimal modality for local staging of gynecological tumors. Advances in functional MRI with diffusion-weighted and dynamic contrast-enhanced sequences provide more detailed information regarding tumor cellularity, vascularity, and viability. Fluorodeoxyglucose positron emission ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0640-3

    authors: Khan SR,Arshad M,Wallitt K,Stewart V,Bharwani N,Barwick TD

    更新日期:2017-11-06 00:00:00

  • Reirradiation of Skull Base Tumors With Advanced Highly Conformal Techniques.

    abstract:PURPOSE OF REVIEW:Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancemen...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0639-9

    authors: Ho JC,Phan J

    更新日期:2017-10-28 00:00:00

  • Nutrition and Aging: a Practicing Oncologist's Perspective.

    abstract::Malnutrition is common in patients with cancer and is associated with a variety of negative outcomes. These can include reduced treatment tolerance and worsened cancer prognosis. Various aspects of aging, including sensory, physical, or psychosocial changes, place older patients at a particularly high risk for malnutr...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0630-5

    authors: Jain R,Dotan E

    更新日期:2017-09-07 00:00:00

  • New Hypofractionation Radiation Strategies for Glioblastoma.

    abstract:PURPOSE OF REVIEW:Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of less than 2 years despite the standard of care treatment of 6 weeks of chemoradiotherapy. We review the data investigating hypofractionated radiotherapy (HFRT) in the treatment of newly diagnosed ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0616-3

    authors: Azoulay M,Shah J,Pollom E,Soltys SG

    更新日期:2017-09-01 00:00:00

  • Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent Therapeutics.

    abstract:PURPOSE OF REVIEW:The knowledge base of malignant cell growth and resulting targets is rapidly increasing every day. Clonal theory is essential to understand the changes required for a cell to become malignant. These changes are then clues to therapeutic intervention strategies. Immune system optimization is a critical...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0625-2

    authors: Messerschmidt JL,Bhattacharya P,Messerschmidt GL

    更新日期:2017-08-12 00:00:00

  • Early Cervical Cancer: Current Dilemmas of Staging and Surgery.

    abstract:PURPOSE OF REVIEW:Advances in cervical cancer screening and treatment have resulted in high cure rates in developed countries for early-stage disease. Current research focuses on minimizing morbidity and maximizing quality of life. RECENT FINDINGS:Imaging has been disappointing in identifying small volume metastases. ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0614-5

    authors: Zigras T,Lennox G,Willows K,Covens A

    更新日期:2017-08-01 00:00:00

  • Telemedicine and Palliative Care: an Increasing Role in Supportive Oncology.

    abstract::With the emergence of telemedicine as a routine form of care in various venues, the opportunities to use technology to care for the most vulnerable, most ill cancer patients are extremely appealing. Increasingly, evidence supports early integration of palliative care with standard oncologic care, supported by recent N...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0600-y

    authors: Worster B,Swartz K

    更新日期:2017-06-01 00:00:00

  • Optimal Therapy for Early-Stage Hodgkin's Lymphoma: Risk Adapting, Response Adapting, and Role of Radiotherapy.

    abstract:PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0592-7

    authors: Filippi AR,Levis M,Parikh R,Hoppe B

    更新日期:2017-05-01 00:00:00

  • Immune Checkpoint Inhibitors in Gliomas.

    abstract:PURPOSE OF REVIEW:Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable. Novel therapies to improve outcomes are needed and immune checkpoint inhibitors hold significant promise. RECENT FINDINGS:A limited body of preclin...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11912-017-0586-5

    authors: Tan AC,Heimberger AB,Khasraw M

    更新日期:2017-04-01 00:00:00

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