Abstract：
PURPOSE OF REVIEW:The aim of this review is to sum up the state of the art of urachal carcinoma (UC) in order to easily guide clinicians. RECENT FINDINGS:UC is a rare and aggressive disease with consequent few data about diagnosis and treatment. Dates are mainly based on retrospective trial and case reports with limited prospective trial. Clinical presentation is not specific, often with urinary symptoms. Diagnosis is mainly based on CT scan and MRI, useful to evaluate local invasion and nodal status and to detect the presence of distant metastases. Therefore, biopsy is needed to obtain histological confirmation. Surgery is the gold standard for localized disease, while different chemotherapy schemes have been used in metastatic setting. Novel findings based on mutational analysis of the tumor include the use of biological treatment, such as cetuximab, and immunotherapy, such as atezolizumab, with satisfactory responses, suggesting that personalized treatment could be the most suitable option for UC.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Claps M,Stellato M,Zattarin E,Mennitto A,Sepe P,Guadalupi V,Mennitto R,de Braud FGM,Verzoni E,Procopio Gdoi
10.1007/s11912-020-0878-zsubject
Has Abstractpub_date
2020-01-27 00:00:00pages
9issue
1eissn
1523-3790issn
1534-6269pii
10.1007/s11912-020-0878-zjournal_volume
22pub_type
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