Systemic Therapies for Advanced Squamous Cell Anal Cancer.


PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, ever-conducted, randomised trial in the first-line setting, investigation of immunotherapy in the refractory setting and use of comprehensive genomic profiling for a better molecular characterisation of this disease and the identification of novel potential targets. The combination of a platinum agent and a fluoropyrimidine is generally considered the standard first-line treatment. Other cytotoxic agents, especially docetaxel and paclitaxel, have shown activity in both the chemotherapy-naive and chemo-refractory setting and are currently being investigated in clinical trials. Finally, further to the promising results of early clinical trials, immunotherapy with checkpoint inhibitors (i.e. nivolumab and pembrolizumab) is likely to become a standard second-line treatment option.


Curr Oncol Rep


Current oncology reports


Sclafani F,Rao S




Has Abstract


2018-05-04 00:00:00














  • Shifting from clinical to biologic indicators of prognosis after resection of hepatic colorectal metastases.

    abstract::Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Pawlik TM,Choti MA

    更新日期:2007-05-01 00:00:00

  • Preoperative and adjuvant treatment of localized rectal cancer.

    abstract::Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservat...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Das P,Crane CH

    更新日期:2006-05-01 00:00:00

  • Genomic Characterization of High-Grade Serous Ovarian Cancer: Dissecting Its Molecular Heterogeneity as a Road Towards Effective Therapeutic Strategies.

    abstract::High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of the ovarian cancer deaths, but over the last years little improvement in overall survival has been achieved. HGSOC is a molecularly and clinically heterogeneous disease. At genomic level, it represents a C-class malignancy having frequent gene lo...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Mittempergher L

    更新日期:2016-07-01 00:00:00

  • Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia.

    abstract::Most patients with chronic lymphocytic leukemia are diagnosed at an early stage, when traditional staging systems fail to distinguish those with an aggressive disease course from those with an excellent prognosis. This failure underscores the need for better prognostic markers. Although many markers have been explored...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Jain N,Lamanna N

    更新日期:2009-09-01 00:00:00

  • Should eligible patients with T-cell lymphoma receive high-dose therapy and autologous stem cell transplant in the upfront setting?

    abstract::Peripheral T-cell lymphomas (PTCL) are rare and aggressive subtypes of non-Hodgkin's lymphoma. Compared to B cell lymphomas, the immunologic phenotype of PTCL portends a poorer prognosis, with the exception of anaplastic large cell lymphoma bearing the anaplastic lymphoma kinase protein. Patients with PTCL tend to pre...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Casulo C,Horwitz S

    更新日期:2010-11-01 00:00:00

  • Success at last: a molecular factor that informs treatment.

    abstract::Anaplastic oligodendrogliomas are rare primary brain tumors. However, they respond more effectively to treatment and have a better prognosis than commoner varieties. About 25 year ago, reports emerged that oligodendrogliomas can respond robustly and durably to chemotherapy with procarbazine, lomustine (CCNU), and vinc...

    journal_title:Current oncology reports

    pub_type: 杂志文章


    authors: Lassman AB

    更新日期:2013-02-01 00:00:00

  • Update on treatment advances in combined-modality therapy for anal and rectal carcinomas.

    abstract::Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Meyer J,Balch G,Willett C,Czito B

    更新日期:2011-06-01 00:00:00

  • Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base.

    abstract::Chordomas and chondrosarcomas of the skull base are rare, indolent tumors with a natural history of locally invading their surroundings. Safe, maximal resection is the mainstay of treatment, followed by adjuvant radiation therapy. Even with multimodality therapy, local recurrence remains the most common failure patter...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Nguyen QN,Chang EL

    更新日期:2008-07-01 00:00:00

  • Particle Radiation Therapy for Gastrointestinal Cancers.

    abstract::Particle irradiation of cancerous disease has gained great traction in recent years. The ability for particle therapy centers to deliver radiation with a highly conformal dose distribution while maintaining minimal exit or excess dose delivered to normal tissue, coupled with various biological advantages particularly ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Shinoto M,Ebner DK,Yamada S

    更新日期:2016-03-01 00:00:00

  • Current Understanding of Urachal Adenocarcinoma and Management Strategy.

    abstract:PURPOSE OF REVIEW:The aim of this review is to sum up the state of the art of urachal carcinoma (UC) in order to easily guide clinicians. RECENT FINDINGS:UC is a rare and aggressive disease with consequent few data about diagnosis and treatment. Dates are mainly based on retrospective trial and case reports with limit...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Claps M,Stellato M,Zattarin E,Mennitto A,Sepe P,Guadalupi V,Mennitto R,de Braud FGM,Verzoni E,Procopio G

    更新日期:2020-01-27 00:00:00

  • Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy.

    abstract:PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Gentzler RD,Riley DO,Martin LW

    更新日期:2020-08-15 00:00:00

  • Early-stage Hodgkin's disease.

    abstract::Treatment of Hodgkin's disease (HD) is strictly dependent on stage. Historically, early-stage HD included the limited stages I, II, and IIIA (according to the Cotswolds modification of the Ann Arbor classsification), whereas advanced HD included stage III with B symptoms and stage IV. It was then observed that early-s...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Josting A,Diehl V

    更新日期:2001-05-01 00:00:00

  • MEK inhibition in the treatment of advanced melanoma.

    abstract::The RAS-RAF-MEK-ERK pathway is considered to be the most important signal transduction pathway in melanoma, and alterations in this pathway via various genetic mutations, such as BRAF and NRAS mutations, are known to be important drivers of melanomagenesis. As MEK is an essential intermediary kinase protein within thi...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Salama AK,Kim KB

    更新日期:2013-10-01 00:00:00

  • The Potential Role of Symptom Questionnaires in Palliative and Supportive Cancer Care Delivery.

    abstract:PURPOSE OF REVIEW:The American Society of Clinical Oncology (ASCO) palliative care recommendations have been updated into a full guideline. Symptom questionnaires-completed and reviewed with patients during care delivery-are poised to play a large role in this guideline because they provide a more comprehensive underst...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Stover AM,Basch EM

    更新日期:2017-02-01 00:00:00

  • Palliative Care in Lung Cancer: When to Start.

    abstract:PURPOSE OF REVIEW:Despite recent advances in the care of patients with advanced non-small cell lung cancer (NSCLC), significant morbidity and mortality remains. Symptoms caused by the cancer and its treatments can be profoundly debilitating. Palliative care aims to reduce this burden. In this review, we discuss the def...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Bhattacharya P,Dessain SK,Evans TL

    更新日期:2018-11-09 00:00:00

  • VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy.

    abstract::The therapeutic landscape for renal cell carcinoma (RCC) has changed drastically over the past several years with the emergence of molecularly targeted therapies. With previous prognostic and predictive tools based on studies of patients treated with cytokine therapies, confirmation of these prior methods and discover...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Cowey CL,Rathmell WK

    更新日期:2009-03-01 00:00:00

  • Guiding Treatment Choices for Elderly Patients with Glioblastoma by a Comprehensive Geriatric Assessment.

    abstract:PURPOSE OF REVIEW:The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate stan...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Lütgendorf-Caucig C,Freyschlag C,Masel EK,Marosi C

    更新日期:2020-07-10 00:00:00

  • What's New in Imaging for Gynecologic Cancer?

    abstract::Magnetic resonance imaging (MRI) is the optimal modality for local staging of gynecological tumors. Advances in functional MRI with diffusion-weighted and dynamic contrast-enhanced sequences provide more detailed information regarding tumor cellularity, vascularity, and viability. Fluorodeoxyglucose positron emission ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Khan SR,Arshad M,Wallitt K,Stewart V,Bharwani N,Barwick TD

    更新日期:2017-11-06 00:00:00

  • The clinical importance of quality-of-life scores in patients with skull base tumors: a meta-analysis and review of the literature.

    abstract::Health-related quality of life (QOL) outcomes are frequently used by clinicians, patients, and researchers for assessing the effectiveness of an intervention. Small differences in QOL may be statistically significant but their clinical relevance remains undefined. The smallest changes in QOL scores of the anterior sku...

    journal_title:Current oncology reports

    pub_type: 杂志文章,meta分析,评审


    authors: Amit M,Abergel A,Fliss DM,Gil Z

    更新日期:2012-04-01 00:00:00

  • Maintenance and consolidation strategies in non-Hodgkin's lymphoma: A review of the data.

    abstract::Results of treatment for patients with non-Hodgkin's lymphomas have significantly improved over the last decade, especially following the discovery that anti-CD20 antibody therapy can significantly change the outlook for patients with both aggressive and indolent lymphomas. Although investigators have previously attem...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Hagemeister FB

    更新日期:2010-11-01 00:00:00

  • Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications.

    abstract:PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Hosein AN,Beg MS

    更新日期:2018-05-11 00:00:00

  • Lymphovascular Space Invasion as a Risk Factor in Early Endometrial Cancer.

    abstract::Management of early endometrial cancer is contentious these days with little agreement between oncologists as well as across MDTs or tumour boards and indeed across countries. This is because of the state of knowledge with regards to risk factors in early endometrial cancer; although we recognise risk factors affect o...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Sadozye AH,Harrand RL,Reed NS

    更新日期:2016-04-01 00:00:00

  • High-risk non-melanoma skin cancer of the head and neck.

    abstract::High-risk non-melanoma skin cancer (NMSC) of the head and neck is difficult to manage, given its propensity for regional metastasis, perineural invasion, direct parotid invasion, and bony destruction. Management of these tumors demands awareness of the characteristics contributing to their recurrence. Recent studies e...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Lai SY,Weber RS

    更新日期:2005-03-01 00:00:00

  • Beyond rituximab: the future of monoclonal antibodies in B-cell non-Hodgkin lymphoma.

    abstract::The treatment of non-Hodgkin lymphoma (NHL) has changed dramatically since the introduction of rituximab, a monoclonal antibody that binds to the B-cell transmembrane protein CD20 and causes lysis of the lymphoma cells. Since then, a number of additional antibodies have been tested against other B-cell targets, result...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Sikder MA,Friedberg JW

    更新日期:2008-09-01 00:00:00

  • Neoadjuvant therapy for breast cancer: assessing treatment progress and managing poor responders.

    abstract::There is no clear consensus regarding the most effective management of poor responders to neoadjuvant chemotherapy. Intensifying or changing primary systemic treatment has not been shown to offer any benefit. There is a paucity of trials testing the utility of adjuvant chemotherapy in this setting. Adjuvant hormonal t...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Wesolowski R,Budd GT

    更新日期:2009-01-01 00:00:00

  • Topoisomerase I targeting agents in small-cell lung cancer.

    abstract::The topoisomerase I inhibitors such as irinotecan and topotecan are active agents against small-cell lung cancer that are effective in treating not only chemotherapy-naïve tumors but also progressed-stage tumors after treatment with cisplatin-based regimens, because their mechanism of antitumor activity differs from t...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Ohe Y,Saijo N

    更新日期:2001-03-01 00:00:00

  • Interventions that Facilitate Shared Decision-Making in Cancers with Active Surveillance as Treatment Option: a Systematic Review of Literature.

    abstract:PURPOSE OF REVIEW:Medical decisions concerning active surveillance are complex, especially when evidence on superiority of one of the treatments is lacking. Decision aids have been developed to facilitate shared decision-making on whether to pursue an active surveillance strategy. However, it is unclear how these decis...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Collée GE,van der Wilk BJ,van Lanschot JJB,Busschbach JJ,Timmermans L,Lagarde SM,Kranenburg LW

    更新日期:2020-07-28 00:00:00

  • Robotic surgery for gynaecologic cancer: an overview.

    abstract::After decades of reluctance to change surgical approaches, new technologies have created new perspectives for surgery. Initially, the laparoscopic approach was considered to be only one useful for relatively simple procedures as the design of the instruments and the limited access hampered free movements to perform co...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Verheijen R,Zweemer R

    更新日期:2012-12-01 00:00:00

  • Gastric carcinoma.

    abstract::Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Phan AT,Ajani JA

    更新日期:2004-05-01 00:00:00

  • The role of vascular endothelial growth factor in the pathogenesis, diagnosis and treatment of malignant pleural effusion.

    abstract::Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...

    journal_title:Current oncology reports

    pub_type: 杂志文章,评审


    authors: Bradshaw M,Mansfield A,Peikert T

    更新日期:2013-06-01 00:00:00