Systemic Therapies for Advanced Squamous Cell Anal Cancer.

Abstract:

PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, ever-conducted, randomised trial in the first-line setting, investigation of immunotherapy in the refractory setting and use of comprehensive genomic profiling for a better molecular characterisation of this disease and the identification of novel potential targets. The combination of a platinum agent and a fluoropyrimidine is generally considered the standard first-line treatment. Other cytotoxic agents, especially docetaxel and paclitaxel, have shown activity in both the chemotherapy-naive and chemo-refractory setting and are currently being investigated in clinical trials. Finally, further to the promising results of early clinical trials, immunotherapy with checkpoint inhibitors (i.e. nivolumab and pembrolizumab) is likely to become a standard second-line treatment option.

journal_name

Curr Oncol Rep

journal_title

Current oncology reports

authors

Sclafani F,Rao S

doi

10.1007/s11912-018-0698-6

subject

Has Abstract

pub_date

2018-05-04 00:00:00

pages

53

issue

7

eissn

1523-3790

issn

1534-6269

pii

10.1007/s11912-018-0698-6

journal_volume

20

pub_type

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