Immunotherapy in Anal Cancer.

abstract：PURPOSE OF REVIEW:The knowledge base of malignant cell growth and resulting targets is rapidly increasing every day. Clonal theory is essential to understand the changes required for a cell to become malignant. These changes are then clues to therapeutic intervention strategies. Immune system optimization is a critical...

journal_title：Current oncology reports

authors： Messerschmidt JL,Bhattacharya P,Messerschmidt GL

更新日期：2017-08-12 00:00:00

abstract：:Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor...

journal_title：Current oncology reports

authors： Pawlik TM,Choti MA

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...

journal_title：Current oncology reports

authors： Pinkerton R,Mitchell G,Hardy J

更新日期：2020-03-13 00:00:00

abstract：PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, e...

journal_title：Current oncology reports

authors： Sclafani F,Rao S

更新日期：2018-05-04 00:00:00

abstract：:Anaplastic oligodendrogliomas are rare primary brain tumors. However, they respond more effectively to treatment and have a better prognosis than commoner varieties. About 25 year ago, reports emerged that oligodendrogliomas can respond robustly and durably to chemotherapy with procarbazine, lomustine (CCNU), and vinc...

journal_title：Current oncology reports

authors： Lassman AB

更新日期：2013-02-01 00:00:00

abstract：:Particle irradiation of cancerous disease has gained great traction in recent years. The ability for particle therapy centers to deliver radiation with a highly conformal dose distribution while maintaining minimal exit or excess dose delivered to normal tissue, coupled with various biological advantages particularly ...

journal_title：Current oncology reports

authors： Shinoto M,Ebner DK,Yamada S

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Management of metastatic head and neck squamous cell cancers (HNSCC) can be challenging. This review gives an insight of current treatment options for patients with synchronous metastatic HNSCC and suggests a therapeutic algorithm. RECENT FINDINGS:With the rise of novel therapeutic techniques and med...

journal_title：Current oncology reports

authors： Tang E,Lahmi L,Meillan N,Pietta G,Albert S,Maingon P

更新日期：2019-11-14 00:00:00

abstract：:HER2 is a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases and is involved in the growth, invasion, metastasis, and prognosis of breast cancer. The rationale for prospective trials evaluating the role of anti-HER2 monoclonal antibody therapy for patients with high-risk HER2-positive res...

journal_title：Current oncology reports

authors： Perez EA

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...

journal_title：Current oncology reports

authors： Filippi AR,Levis M,Parikh R,Hoppe B

更新日期：2017-05-01 00:00:00

abstract：:Mutations in the cancer susceptibility genes BRCA1 and BRCA2 are associated with significantly increased risks of breast and ovarian cancer. Fortunately, effective strategies are available to reduce these risks, including genetic testing, which is an important consideration in determining management of patients with a...

journal_title：Current oncology reports

authors： Gulati AP,Domchek SM

更新日期：2008-01-01 00:00:00

abstract：:There is no clear consensus regarding the most effective management of poor responders to neoadjuvant chemotherapy. Intensifying or changing primary systemic treatment has not been shown to offer any benefit. There is a paucity of trials testing the utility of adjuvant chemotherapy in this setting. Adjuvant hormonal t...

journal_title：Current oncology reports

authors： Wesolowski R,Budd GT

更新日期：2009-01-01 00:00:00

abstract：:Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With t...

journal_title：Current oncology reports

authors： Shukla NN,Trippett TM

更新日期：2006-09-01 00:00:00

abstract：:Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head. It is usually a large B-cell non-Hodgkin's lymphoma. PIOL typically presents as a vitritis that is unresponsive to corticosteroid t...

journal_title：Current oncology reports

authors： Kim SK,Chan CC,Wallace DJ

更新日期：2005-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of death from cancer worldwide and has a poor overall survival across all stages of disease. The recent advancement of gene expression technology addresses the phenotypic complexity of many diseases, including NSCLC. These genomic approaches have shown great prom...

journal_title：Current oncology reports

authors： Jolly Graham A,Potti A

更新日期：2009-07-01 00:00:00

abstract：:Chemotherapy was traditionally perceived to be ineffective for prostate cancer and was only administered to patients with symptomatic hormone-refractory disease. Although previous reviews have confirmed this belief, recent studies have demonstrated significant antitumor activity with chemotherapy regimens. This articl...

journal_title：Current oncology reports

authors： Petrylak DP

更新日期：2003-05-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the intestinal tract, are characterized by the expression of KIT, also known as CD117. Increasingly, primary tumors from novel sites are being described. The KIT gene is commonly mutated, causing constitutive activation of the protein and a...

journal_title：Current oncology reports

authors： von Mehren M

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable. Novel therapies to improve outcomes are needed and immune checkpoint inhibitors hold significant promise. RECENT FINDINGS:A limited body of preclin...

journal_title：Current oncology reports

authors： Tan AC,Heimberger AB,Khasraw M

更新日期：2017-04-01 00:00:00

abstract：:Management of early endometrial cancer is contentious these days with little agreement between oncologists as well as across MDTs or tumour boards and indeed across countries. This is because of the state of knowledge with regards to risk factors in early endometrial cancer; although we recognise risk factors affect o...

journal_title：Current oncology reports

authors： Sadozye AH,Harrand RL,Reed NS

更新日期：2016-04-01 00:00:00

abstract：:Chronic opioid therapy (defined as greater than 3 months on opioids) is a common practice for those with non-cancer pain, cancer survivors with treatment-related pain, and individuals with cancer undergoing disease-modifying therapy with a survival that can be for a year or more. Recent studies have found unique long-...

journal_title：Current oncology reports

authors： Davis MP,Mehta Z

更新日期：2016-12-01 00:00:00

abstract：:Malnutrition is common in patients with cancer and is associated with a variety of negative outcomes. These can include reduced treatment tolerance and worsened cancer prognosis. Various aspects of aging, including sensory, physical, or psychosocial changes, place older patients at a particularly high risk for malnutr...

journal_title：Current oncology reports

authors： Jain R,Dotan E

更新日期：2017-09-07 00:00:00

abstract：PURPOSE OF REVIEW:The calculation of noncancer-specific life expectancy can guide shared decision-making and avoid over- and undertreatment in older adults with cancer. Several factors determine life expectancy, including socio-demographic background, comorbidities, physical performance, and geriatric assessment variab...

journal_title：Current oncology reports

authors： Verduzco-Aguirre HC,Gomez-Moreno C,Chavarri-Guerra Y,Soto-Perez-de-Celis E

更新日期：2019-06-25 00:00:00

abstract：:Overall survival for patients with squamous cell carcinoma of the head and neck (SCCHN) has not improved appreciably over the past few decades. Because standard treatments have not controlled this disease with sufficiently high success rates, novel therapeutic approaches, such as immunotherapy, are under investigation...

journal_title：Current oncology reports

authors： Leibowitz MS,Nayak JV,Ferris RL

更新日期：2008-03-01 00:00:00

abstract：:Cervical cancer constitutes a leading cause of morbidity and cancer deaths in women throughout the world. Approximately two thirds of the patients are diagnosed with locally advanced cervical cancer, showing disappointing survival rates despite correct multidisciplinary management. Metastatic disease implies a poor pr...

journal_title：Current oncology reports

authors： Marquina G,Manzano A,Casado A

更新日期：2018-04-02 00:00:00

abstract：PURPOSE OF REVIEW:Patients with cancer have an elevated risk of cardiovascular disease. This review describes the cardiovascular risks of different cancer therapies and the evidence for cardioprotective strategies. RECENT FINDINGS:Recent studies have provided additional support for the safety and efficacy of dexrazoxa...

journal_title：Current oncology reports

authors： Upshaw JN

更新日期：2020-06-20 00:00:00

abstract：:Many women undergo mastectomy as treatment of their breast cancer either because of personal preference or because of tumor-related factors making mastectomy the preferred surgical option. The use of postmastectomy radiation therapy has been shown to decrease the risk of local recurrence and in some cases improve over...

journal_title：Current oncology reports

authors： Lyons JA,Sherertz T

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Improved management of infectious complications of acute myeloid leukemia (AML) has contributed substantially to the success of care over the past half century. An important approach to reducing infectious complications during the induction period of chemotherapy involves the use of prophylactic antib...

journal_title：Current oncology reports

authors： McCarthy MW,Walsh TJ

更新日期：2017-03-01 00:00:00

abstract：:Radiation-induced mucositis is an important dose-limiting acute side effect associated with the treatment of tumors of the upper aerodigestive tract. The toxicity of radiation therapy increases with prior or concurrent administration of some chemotherapeutic agents. Pretreatment eradication of infection, maintenance o...

journal_title：Current oncology reports

authors： Johnson JT

更新日期：2001-01-01 00:00:00

abstract：:Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...

journal_title：Current oncology reports

authors： Meyer J,Balch G,Willett C,Czito B

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma (MCL) prognosis is strictly related to the characteristics of the disease, which can range from very indolent cases to highly aggressive and refractory ones. Here we will review the current knowledge on MCL biomarkers. RECENT FINDINGS:Biomarker-informed diagnosis is essential for...

journal_title：Current oncology reports

authors： Condoluci A,Rossi D,Zucca E,Cavalli F

更新日期：2018-08-22 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates. RECENT FINDINGS:There is an increased understanding of subcellular changes in vulvar malignancies. These p...

journal_title：Current oncology reports

authors： Williams A,Syed S,Velangi S,Ganesan R

更新日期：2019-08-15 00:00:00