Targeted Agents in Cervical Cancer: Beyond Bevacizumab.

abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

journal_title：Current oncology reports

authors： Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

更新日期：2018-04-10 00:00:00

abstract：:The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become the standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target...

journal_title：Current oncology reports

authors： Hayman SR,Leung N,Grande JP,Garovic VD

更新日期：2012-08-01 00:00:00

abstract：:Osteoporosis is a disease that causes substantial morbidity and mortality for which preventive therapy is available. Women with breast cancer are at increased risk for osteoporosis for several reasons, including premature ovarian failure as a result of treatment, direct effects of chemotherapy, and effects of the brea...

journal_title：Current oncology reports

authors： Mincey BA

更新日期：2003-01-01 00:00:00

abstract：:Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, ei...

journal_title：Current oncology reports

authors： Howell SJ,Shalet SM

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The American Society of Clinical Oncology (ASCO) palliative care recommendations have been updated into a full guideline. Symptom questionnaires-completed and reviewed with patients during care delivery-are poised to play a large role in this guideline because they provide a more comprehensive underst...

journal_title：Current oncology reports

authors： Stover AM,Basch EM

更新日期：2017-02-01 00:00:00

abstract：:Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the...

journal_title：Current oncology reports

authors： Ramos JC,Lossos IS

更新日期：2011-10-01 00:00:00

abstract：:The number of patients given neoadjuvant chemotherapy (NAC) followed by fertility-sparing surgery in cervical cancer is still scarce. Only a few centres perform these procedures, and thus, such procedures remain largely in the experimental stage. Patients that do not fulfil the criteria for standard fertility-sparing ...

journal_title：Current oncology reports

authors： Robova H,Rob L,Halaska MJ,Pluta M,Skapa P

更新日期：2015-01-01 00:00:00

abstract：:Many women undergo mastectomy as treatment of their breast cancer either because of personal preference or because of tumor-related factors making mastectomy the preferred surgical option. The use of postmastectomy radiation therapy has been shown to decrease the risk of local recurrence and in some cases improve over...

journal_title：Current oncology reports

authors： Lyons JA,Sherertz T

更新日期：2014-01-01 00:00:00

abstract：:Mutations in the cancer susceptibility genes BRCA1 and BRCA2 are associated with significantly increased risks of breast and ovarian cancer. Fortunately, effective strategies are available to reduce these risks, including genetic testing, which is an important consideration in determining management of patients with a...

journal_title：Current oncology reports

authors： Gulati AP,Domchek SM

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancemen...

journal_title：Current oncology reports

authors： Ho JC,Phan J

更新日期：2017-10-28 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of ...

journal_title：Current oncology reports

authors： Palmieri DJ,Carlino MS

更新日期：2018-07-31 00:00:00

abstract：:Proton beam radiation therapy (PBRT) has unique physical properties (e.g., Bragg Peak) that limit the amount of normal tissue irradiated in the head and neck region while maximizing the radiation delivered to the tumor. Radiation therapy is commonly used in both the primary and adjuvant setting for many head and neck ...

journal_title：Current oncology reports

authors： Frank SJ,Selek U

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates. RECENT FINDINGS:There is an increased understanding of subcellular changes in vulvar malignancies. These p...

journal_title：Current oncology reports

authors： Williams A,Syed S,Velangi S,Ganesan R

更新日期：2019-08-15 00:00:00

abstract：:Postmastectomy radiotherapy continues to be one of the most controversial issues in breast radiotherapy. At the crux of the controversy lies the lack of conclusive studies that specifically address the risk-benefit ratio of postmastectomy radiotherapy for patients at intermediate risk of developing locoregional recurr...

journal_title：Current oncology reports

authors： Sartor CI

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Improved management of infectious complications of acute myeloid leukemia (AML) has contributed substantially to the success of care over the past half century. An important approach to reducing infectious complications during the induction period of chemotherapy involves the use of prophylactic antib...

journal_title：Current oncology reports

authors： McCarthy MW,Walsh TJ

更新日期：2017-03-01 00:00:00

abstract：:With the emergence of telemedicine as a routine form of care in various venues, the opportunities to use technology to care for the most vulnerable, most ill cancer patients are extremely appealing. Increasingly, evidence supports early integration of palliative care with standard oncologic care, supported by recent N...

journal_title：Current oncology reports

authors： Worster B,Swartz K

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...

journal_title：Current oncology reports

authors： Filippi AR,Levis M,Parikh R,Hoppe B

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies and future strategies. RECENT FINDINGS:The number of PD-1/PD-L1...

journal_title：Current oncology reports

authors： Oliveira LJC,Gongora ABL,Jardim DLF

更新日期：2020-06-12 00:00:00

abstract：:Primary and metastatic spinal mesenchymal tumors are uncommon lesions. Surgical management of these tumors remains a challenge. En bloc wide resection provides the best chance for local tumor control and long-term survival. However, limitations to this technique include technical considerations (including neurovascula...

journal_title：Current oncology reports

authors： Mody MG,Rao G,Rhines LD

更新日期：2006-07-01 00:00:00

abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...

journal_title：Current oncology reports

authors： Rich TA,Crane C,Lawson JD,Landry J

更新日期：2005-05-01 00:00:00

abstract：:Skin cancer is the most common type of cancer in the United States. US incidence of malignant melanoma is increasing faster than any other type of cancer. To minimize increasing morbidity and mortality rates, it is imperative that appropriate screening and early detection of skin cancer become more widespread. All phy...

journal_title：Current oncology reports

authors： Linden KG

更新日期：2004-11-01 00:00:00

abstract：:Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and...

journal_title：Current oncology reports

authors： Johnson CM,Smolenski D

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the long scientific background followed to design guidelines and everyday clinical practice applied to melanoma patients. Surgery is the first option to cure melanoma patients (PTS) at initial diagnosis, since primary cutaneous lesions are usually easily resectable. An excisional...

journal_title：Current oncology reports

authors： Testori AAE,Blankenstein SA,van Akkooi ACJ

更新日期：2019-12-19 00:00:00

abstract：:Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservat...

journal_title：Current oncology reports

authors： Das P,Crane CH

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...

journal_title：Current oncology reports

authors： Yao CMKL,Chang EI,Lai SY

更新日期：2019-11-07 00:00:00

abstract：:The diagnosis of a gynecological malignancy during pregnancy is rare but not uncommon. Cancer treatment during pregnancy is possible, but both maternal and fetal interests need to be respected. Different treatment plans may be justifiable and multidisciplinary treatment is advised. Clinical trials are virtually imposs...

journal_title：Current oncology reports

authors： Han SN,Verheecke M,Vandenbroucke T,Gziri MM,Van Calsteren K,Amant F

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...

journal_title：Current oncology reports

authors： Gentzler RD,Riley DO,Martin LW

更新日期：2020-08-15 00:00:00

abstract：:Results of treatment for patients with non-Hodgkin's lymphomas have significantly improved over the last decade, especially following the discovery that anti-CD20 antibody therapy can significantly change the outlook for patients with both aggressive and indolent lymphomas. Although investigators have previously attem...

journal_title：Current oncology reports

authors： Hagemeister FB

更新日期：2010-11-01 00:00:00

abstract：:Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has emerged as an attractive option in the development of targeted cancer therapy. Three oral agents selectively targeting CDK4/6 have been developed: palbociclib, ...

journal_title：Current oncology reports

authors： Mayer EL

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in cervical cancer screening and treatment have resulted in high cure rates in developed countries for early-stage disease. Current research focuses on minimizing morbidity and maximizing quality of life. RECENT FINDINGS:Imaging has been disappointing in identifying small volume metastases. ...

journal_title：Current oncology reports

authors： Zigras T,Lennox G,Willows K,Covens A

更新日期：2017-08-01 00:00:00