Abstract：
:The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become the standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target vascular endothelial growth factor (VEGF) and/or its receptors, and include bevacizumab, a humanized monoclonal antibody against VEGF, as well as tyrosine kinase inhibitors that target several receptor tyrosine kinases (RTK), including VEGF receptors. These therapies, as a general class of anti-angiogenic medications, have been shown to have common adverse vascular effects attributable directly or indirectly to their anti-VEGF effects, including hypertension, renal vascular injury, often manifested by proteinuria and thrombotic microangiopathy, and congestive heart failure. Knowledge of these common side effects and their underlying mechanisms may allow for more accurate and prompt diagnoses, timely clinical interventions, and the development of rational and standard treatments. These measures may minimize patient morbidity and mortality, not only by the treatment of side effects, but also by minimizing the disruption of treatment of the underlying malignancy, as well as improving patient quality of life.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Hayman SR,Leung N,Grande JP,Garovic VDdoi
10.1007/s11912-012-0242-zsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
285-94issue
4eissn
1523-3790issn
1534-6269journal_volume
14pub_type
杂志文章,评审abstract：:Management of early endometrial cancer is contentious these days with little agreement between oncologists as well as across MDTs or tumour boards and indeed across countries. This is because of the state of knowledge with regards to risk factors in early endometrial cancer; although we recognise risk factors affect o...
journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2008-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2002-03-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2007-05-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2006-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2017-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2008-05-01 00:00:00
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journal_title：Current oncology reports
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journal_title：Current oncology reports
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更新日期：2013-06-01 00:00:00
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journal_title：Current oncology reports
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更新日期：1999-09-01 00:00:00
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journal_title：Current oncology reports
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更新日期：2014-01-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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journal_title：Current oncology reports
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更新日期：2002-01-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2012-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...
journal_title：Current oncology reports
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更新日期：2019-11-07 00:00:00
