Abstract:
:Postmastectomy radiotherapy continues to be one of the most controversial issues in breast radiotherapy. At the crux of the controversy lies the lack of conclusive studies that specifically address the risk-benefit ratio of postmastectomy radiotherapy for patients at intermediate risk of developing locoregional recurrence. A well-designed phase III trial was initiated, but the trial failed to accrue and was closed prematurely, leaving the issue unresolved. Recent data confirm that postmastectomy radiotherapy yields a clear benefit in breast cancer-specific survival. Furthermore, the risk of cardiac morbidity that historically has offset the benefit of postmastectomy radiotherapy appears to be lessening with modern radiotherapy approaches. However, newer, more efficacious systemic therapy regimens may decrease the risk of locoregional recurrence and increase the risk of toxicity from combined-modality therapy. Recent studies attempt to better stratify patients into risk categories based on disease factors and to estimate the benefit of postmastectomy radiotherapy when traditional risk estimates, such as nodal status, are obscured by neoadjuvant systemic therapy. Nonetheless, a clear consensus on the role of postmastectomy radiotherapy remains elusive for patients who are at intermediate risk of locoregional recurrence after mastectomy.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Sartor CIdoi
10.1007/s11912-006-0006-8keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
29-34issue
1eissn
1523-3790issn
1534-6269journal_volume
8pub_type
杂志文章,评审abstract::The therapeutic landscape for renal cell carcinoma (RCC) has changed drastically over the past several years with the emergence of molecularly targeted therapies. With previous prognostic and predictive tools based on studies of patients treated with cytokine therapies, confirmation of these prior methods and discover...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-009-0015-5
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-015-0446-0
更新日期:2015-01-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-011-0161-4
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-011-0191-y
更新日期:2011-12-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,收录出版,评审
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更新日期:2005-07-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00969-w
更新日期:2020-08-15 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-006-0070-0
更新日期:2006-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2020-07-28 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-015-0453-1
更新日期:2015-07-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-003-0068-9
更新日期:2003-07-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-012-0227-y
更新日期:2012-04-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0043-2
更新日期:2001-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0699-5
更新日期:2018-05-11 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-013-0316-6
更新日期:2013-08-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0032-1
更新日期:2007-07-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2020-07-09 00:00:00
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journal_title:Current oncology reports
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更新日期:2020-07-10 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2017-08-12 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0586-5
更新日期:2017-04-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2002-11-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
abstract::Pediatric medicine is moving toward a greater appreciation that the delivery of quality medical care involves a partnership including the health care team, the child, and the family. Pediatric medicine now emphasizes the importance of information exchange among these groups. This paper discusses two models for communi...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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journal_title:Current oncology reports
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更新日期:2000-07-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2016-03-01 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2018-11-09 00:00:00
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journal_title:Current oncology reports
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00