Abstract:
:The endothelins (ETs), which include ET-1, ET-2, ET-3, and their receptors ET-A and ET-B, play a major role in tumor growth, proliferation, apoptosis, angiogenesis, and bone metastasis. Atrasentan is a novel and selective inhibitor of ET-1 and ET-A. In vitro and in vivo data show that this oral agent is capable of inhibiting tumor cells in vitro. More recently, this agent was studied in several phase I trials with refractory carcinoma patients. Subsequently, phase II and III clinical trials evaluating atrasentan in patients with hormone-refractory prostate carcinoma have suggested that targeting this pathway may be a new therapeutic strategy in the treatment of solid malignancies, specifically, prostate cancer.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Thakkar SG,Choueiri TK,Garcia JAdoi
10.1007/s11912-006-0045-1keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
108-13issue
2eissn
1523-3790issn
1534-6269journal_volume
8pub_type
杂志文章abstract:PURPOSE OF REVIEW:The concept of value-based health care (VBHC) was articulated more than a decade ago. However, its clinical implementation remains an on-going process and a particularly demanding one for the domain of head and neck cancer (HNC). These cancers often present with fast growing tumors in functionally and...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00952-5
更新日期:2020-07-10 00:00:00
abstract::With our understanding of human papillomavirus (HPV) and cervical cancer, the availability of HPV testing, and the known limitations of cervical cytology, it is time to reassess cervical cancer screening technologies. This article reviews recent randomized trials comparing primary HPV testing with cervical cytology in...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-008-0081-0
更新日期:2008-11-01 00:00:00
abstract::Inter-individual variability in carcinogen metabolism has been attributed in part to the polymorphic expression of several phase I and II detoxification enzymes. The role of these genetic polymorphisms in cancer susceptibility has been most extensively evaluated for isozymes of cytochrome P450 (CYP1A1, CYP2D6, and CYP...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-000-0075-z
更新日期:2000-05-01 00:00:00
abstract::Malnutrition is common in patients with cancer and is associated with a variety of negative outcomes. These can include reduced treatment tolerance and worsened cancer prognosis. Various aspects of aging, including sensory, physical, or psychosocial changes, place older patients at a particularly high risk for malnutr...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0630-5
更新日期:2017-09-07 00:00:00
abstract::Lung cancer is the most common cause of cancer death worldwide. The overall 5-year survival rate remains disappointing at 14% or less. Several clinician- and community-based interventions show promise for reducing lung cancer incidence through prevention and smoking cessation. However, long-term heavy smokers retain a...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-002-0060-9
更新日期:2002-11-01 00:00:00
abstract::Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-004-0049-7
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Mantle cell lymphoma (MCL) prognosis is strictly related to the characteristics of the disease, which can range from very indolent cases to highly aggressive and refractory ones. Here we will review the current knowledge on MCL biomarkers. RECENT FINDINGS:Biomarker-informed diagnosis is essential for...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0728-4
更新日期:2018-08-22 00:00:00
abstract:PURPOSE OF REVIEW:This review was undertaken to analyze the main reasons behind the limited development of hospice care in China, and to put forward some suggestions. RECENT FINDINGS:Although the Chinese government has increased its support for hospice care in recent years, however, owing to the lack of education arou...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00959-y
更新日期:2020-07-28 00:00:00
abstract::Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With t...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-006-0062-0
更新日期:2006-09-01 00:00:00
abstract::Particle irradiation of cancerous disease has gained great traction in recent years. The ability for particle therapy centers to deliver radiation with a highly conformal dose distribution while maintaining minimal exit or excess dose delivered to normal tissue, coupled with various biological advantages particularly ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-016-0499-8
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The American Society of Clinical Oncology (ASCO) palliative care recommendations have been updated into a full guideline. Symptom questionnaires-completed and reviewed with patients during care delivery-are poised to play a large role in this guideline because they provide a more comprehensive underst...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0571-z
更新日期:2017-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. RECENT FINDI...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00969-w
更新日期:2020-08-15 00:00:00
abstract:PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0699-5
更新日期:2018-05-11 00:00:00
abstract::The introduction of targeted therapies, specifically those that target the VEGF receptor (VEGFR), PDGF receptor (PDGFR) and the mTOR pathways, has significantly changed the approach to patients with unresectable renal cell cancer (RCC). However, drug resistance develops through bypassing of targeted pathways. Regorafe...
journal_title:Current oncology reports
pub_type: 杂志文章
doi:10.1007/s11912-013-0292-x
更新日期:2013-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Advances in cervical cancer screening and treatment have resulted in high cure rates in developed countries for early-stage disease. Current research focuses on minimizing morbidity and maximizing quality of life. RECENT FINDINGS:Imaging has been disappointing in identifying small volume metastases. ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-017-0614-5
更新日期:2017-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies and future strategies. RECENT FINDINGS:The number of PD-1/PD-L1...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00928-5
更新日期:2020-06-12 00:00:00
abstract::Radiation-induced mucositis is an important dose-limiting acute side effect associated with the treatment of tumors of the upper aerodigestive tract. The toxicity of radiation therapy increases with prior or concurrent administration of some chemotherapeutic agents. Pretreatment eradication of infection, maintenance o...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-001-0043-2
更新日期:2001-01-01 00:00:00
abstract::For the subgroup of patients with inoperable gastrointestinal stromal tumors, progress has been made by the rapid development and approval of the targeted therapy imatinib mesylate. Small round cell sarcomas (SRCT), such as Ewing/primitive neuroectodermal tumor, desmoplastic SRCT, and rhabdomyosarcoma, are chemotherap...
journal_title:Current oncology reports
pub_type: 杂志文章,收录出版,评审
doi:10.1007/s11912-005-0054-5
更新日期:2005-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Standard treatment for early-stage squamous cell cancer of the anal canal (SCCA) includes concurrent chemotherapy and radiation to achieve curative intent. Treatment options are limited, however, especially with locoregional disease relapse occurring in 20-30% of patients and about 10-30% of patients ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00946-3
更新日期:2020-07-11 00:00:00
abstract::Peripheral T-cell lymphomas (PTCL) are rare and aggressive subtypes of non-Hodgkin's lymphoma. Compared to B cell lymphomas, the immunologic phenotype of PTCL portends a poorer prognosis, with the exception of anaplastic large cell lymphoma bearing the anaplastic lymphoma kinase protein. Patients with PTCL tend to pre...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-010-0125-0
更新日期:2010-11-01 00:00:00
abstract::Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-011-0186-8
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Advanced urothelial carcinoma (aUC) has long been treated preferably with cisplatin-based chemotherapy, but many patients are cisplatin-ineligible whereas for those who progress on a platinum-based regimen treatment options are limited. We review key recent data regarding immune checkpoint inhibitors ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0693-y
更新日期:2018-04-11 00:00:00
abstract::Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma, comprising approximately 6-8% of all non-Hodgkin lymphomas. MCL is biologically and clinically heterogeneous, and there is no standard treatment for MCL. Although untreated MCL often responds well to frontline combination chemotherapy, relapsed, re...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-015-0460-2
更新日期:2015-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-0900-5
更新日期:2020-03-13 00:00:00
abstract::Primary intraocular lymphoma (PIOL) is a subset of primary central nervous system lymphoma (PCNSL) in which malignant lymphoid cells invade the retina, vitreous body, or optic nerve head. It is usually a large B-cell non-Hodgkin's lymphoma. PIOL typically presents as a vitritis that is unresponsive to corticosteroid t...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-005-0029-6
更新日期:2005-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Older adults with cancer have complex medical needs and often experience higher rates of treatment-related toxicities compared to their younger counterparts. The advent of health information technologies can address multiple gaps in the care of this population. We review the role of existing and emerg...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-018-0672-3
更新日期:2018-03-06 00:00:00
abstract::The result of a lung cancer screening program should be fewer lung cancer-specific deaths in the screened population. Studies evaluating chest imaging as a screening tool for lung cancer have not shown a reduction in lung cancer-specific mortality to date. The ability of institutions using chest imaging to meet the cr...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0032-1
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate stan...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-020-00951-6
更新日期:2020-07-10 00:00:00
abstract::Brain metastases seem to be an almost inevitable complication in patients with metastatic melanoma. Except for the rare patients who can undergo successful surgical resection of brain metastases, current management strategies do not appear adequate and result in a poor outcome (median survival, 2-4 months). In recent ...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-007-0056-6
更新日期:2007-09-01 00:00:00
abstract::The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become the standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target...
journal_title:Current oncology reports
pub_type: 杂志文章,评审
doi:10.1007/s11912-012-0242-z
更新日期:2012-08-01 00:00:00