Transformation of Old Concepts for a New Era of Cancer Immunotherapy: Cytokine Therapy and Cancer Vaccines as Combination Partners of PD1/PD-L1 Inhibitors.

abstract：:Primary and metastatic spinal mesenchymal tumors are uncommon lesions. Surgical management of these tumors remains a challenge. En bloc wide resection provides the best chance for local tumor control and long-term survival. However, limitations to this technique include technical considerations (including neurovascula...

journal_title：Current oncology reports

authors： Mody MG,Rao G,Rhines LD

更新日期：2006-07-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of death from cancer worldwide and has a poor overall survival across all stages of disease. The recent advancement of gene expression technology addresses the phenotypic complexity of many diseases, including NSCLC. These genomic approaches have shown great prom...

journal_title：Current oncology reports

authors： Jolly Graham A,Potti A

更新日期：2009-07-01 00:00:00

abstract：:Management of tumors of the salivary glands requires a detailed understanding of the anatomy and pathologic processes affecting these glands. Salivary glands give rise to benign and malignant neoplasms and are affected by a variety of systemic diseases. CT remains the most common primary imaging study; magnetic resona...

journal_title：Current oncology reports

authors： Scianna JM,Petruzzelli GJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades, advances have been made in understanding the pathophysiology of cancer-associated weight loss, termed "cachexia." To date, there is no proven effective intervention to completely reverse cachexia and there are no approved drug therapies to treat it. This paper will review re...

journal_title：Current oncology reports

authors： Reid J,McKeaveney C,Martin P

更新日期：2019-02-04 00:00:00

abstract：PURPOSE OF REVIEW:The calculation of noncancer-specific life expectancy can guide shared decision-making and avoid over- and undertreatment in older adults with cancer. Several factors determine life expectancy, including socio-demographic background, comorbidities, physical performance, and geriatric assessment variab...

journal_title：Current oncology reports

authors： Verduzco-Aguirre HC,Gomez-Moreno C,Chavarri-Guerra Y,Soto-Perez-de-Celis E

更新日期：2019-06-25 00:00:00

abstract：:Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil (5-FU) and mitomycin results in high rates of local control and...

journal_title：Current oncology reports

authors： Czito BG,Willett CG

更新日期：2009-05-01 00:00:00

abstract：:Patients with head and neck cancers are excellent candidates for gene therapy. With few effective alternatives for patients with recurrent or locally metastatic disease, gene therapy offers a new approach for local control and the possibility to enhance other treatment modalities as well. Different therapeutic genes, ...

journal_title：Current oncology reports

authors： Clayman GL,Dreiling L

更新日期：1999-01-01 00:00:00

abstract：:Following resection of hepatic colorectal metastases, there are few criteria for predicting which patients have more aggressive disease and are, therefore, more likely to experience recurrence and reduced survival. Traditionally, primary tumor stage, preoperative carcinoembryonic antigen level, time from primary tumor...

journal_title：Current oncology reports

authors： Pawlik TM,Choti MA

更新日期：2007-05-01 00:00:00

abstract：:The therapeutic landscape for renal cell carcinoma (RCC) has changed drastically over the past several years with the emergence of molecularly targeted therapies. With previous prognostic and predictive tools based on studies of patients treated with cytokine therapies, confirmation of these prior methods and discover...

journal_title：Current oncology reports

authors： Cowey CL,Rathmell WK

更新日期：2009-03-01 00:00:00

abstract：:Anaplastic oligodendrogliomas are rare primary brain tumors. However, they respond more effectively to treatment and have a better prognosis than commoner varieties. About 25 year ago, reports emerged that oligodendrogliomas can respond robustly and durably to chemotherapy with procarbazine, lomustine (CCNU), and vinc...

journal_title：Current oncology reports

authors： Lassman AB

更新日期：2013-02-01 00:00:00

abstract：:Dysregulation of the cell cycle is a classic hallmark of cancer growth and metastatic potential. Re-establishing cell cycle control through CDK inhibition has emerged as an attractive option in the development of targeted cancer therapy. Three oral agents selectively targeting CDK4/6 have been developed: palbociclib, ...

journal_title：Current oncology reports

authors： Mayer EL

更新日期：2015-01-01 00:00:00

abstract：:Peripheral T-cell lymphomas (PTCL) are rare and aggressive subtypes of non-Hodgkin's lymphoma. Compared to B cell lymphomas, the immunologic phenotype of PTCL portends a poorer prognosis, with the exception of anaplastic large cell lymphoma bearing the anaplastic lymphoma kinase protein. Patients with PTCL tend to pre...

journal_title：Current oncology reports

authors： Casulo C,Horwitz S

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable. Novel therapies to improve outcomes are needed and immune checkpoint inhibitors hold significant promise. RECENT FINDINGS:A limited body of preclin...

journal_title：Current oncology reports

authors： Tan AC,Heimberger AB,Khasraw M

更新日期：2017-04-01 00:00:00

abstract：:Although gastric cancer is still a worldwide major public health concern, it remains relatively uncommon in the Western countries. Despite improvement in surgical morbidity and mortality, as well as significant advancement of chemotherapy and radiotherapy options, the survival for gastric cancer has not significantly ...

journal_title：Current oncology reports

authors： Phan AT,Ajani JA

更新日期：2004-05-01 00:00:00

abstract：:Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With t...

journal_title：Current oncology reports

authors： Shukla NN,Trippett TM

更新日期：2006-09-01 00:00:00

abstract：:Siltuximab is a chimeric monoclonal antibody targeting interleukin-6 (IL-6), which in the fall of 2014 became the first FDA-approved treatment of the rare disease idiopathic multicentric Castleman's disease (MCD). MCD is a non-clonal lymphoproliferative disorder in which common symptoms include fever, night sweats, we...

journal_title：Current oncology reports

authors： Davis CC,Shah KS,Lechowicz MJ

更新日期：2015-07-01 00:00:00

abstract：:The endothelins (ETs), which include ET-1, ET-2, ET-3, and their receptors ET-A and ET-B, play a major role in tumor growth, proliferation, apoptosis, angiogenesis, and bone metastasis. Atrasentan is a novel and selective inhibitor of ET-1 and ET-A. In vitro and in vivo data show that this oral agent is capable of inh...

journal_title：Current oncology reports

authors： Thakkar SG,Choueiri TK,Garcia JA

更新日期：2006-03-01 00:00:00

abstract：:The evolution of our ability to diagnose and classify lymphomas in an increasingly refined manner has paralleled the development of novel technologic approaches, with contemporary practice dependent upon the harnessing of a plethora of data that include microscopic, immunophenotypic, and genetic information. Although ...

journal_title：Current oncology reports

authors： Bagg A

更新日期：2004-09-01 00:00:00

abstract：:Colon cancer remains the third most common cancer, and cause of cancer-related death in the United States. Greater public awareness and acceptance of screening programs have contributed significantly to increasingly earlier detection of colon cancer and decreased mortality. Advances made in the understanding of this d...

journal_title：Current oncology reports

authors： Kumar SK,Goldberg RM

更新日期：2001-03-01 00:00:00

abstract：:Adjuvant treatment of patients with endometrial cancer is tailored to clinical-pathological prognostic factors. Pelvic radiation therapy for stage I endometrial cancer (EC) provides a highly significant improvement of local control, but without survival advantage. Low-risk EC patients have a very favorable prognosis, ...

journal_title：Current oncology reports

authors： Creutzberg CL,Nout RA

更新日期：2011-12-01 00:00:00

abstract：:The use of anti-angiogenic agents as part of the therapeutic armamentarium for advanced stage solid tumors has become the standard of care in several instances, particularly for renal cell carcinoma, non-small cell lung carcinoma, colorectal carcinoma, and gastrointestinal stromal tumors. These agents primarily target...

journal_title：Current oncology reports

authors： Hayman SR,Leung N,Grande JP,Garovic VD

更新日期：2012-08-01 00:00:00

abstract：:Electronic data sharing is a critical, but underappreciated, requirement for modern medical informatics systems. This capability is facilitated by acquisition of structured clinical data, but optimized only if this data is stored and transmitted using standardized representations. Most electronic medical record and cl...

journal_title：Current oncology reports

authors： Jones RB,Reeves D,Martinez CS

更新日期：2012-12-01 00:00:00

abstract：:Gamma-(γ)-herpes virus lymphomas comprise a heterogenous group of B-cell and T-cell neoplasms most commonly associated with Epstein-Barr virus and rarely human herpes virus-8 infection. Adult T-cell leukemia/lymphoma (ATLL) is a unique disease entity caused by the human T-cell lymphotrophic virus, type 1 (HTLV-I), the...

journal_title：Current oncology reports

authors： Ramos JC,Lossos IS

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...

journal_title：Current oncology reports

authors： Pinkerton R,Mitchell G,Hardy J

更新日期：2020-03-13 00:00:00

abstract：PURPOSE OF REVIEW:Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there has been little in the way of novel therapeutics for this malignancy over the last several decades. Derangements in metabolic circuitry favoring excess glycolysis...

journal_title：Current oncology reports

authors： Hosein AN,Beg MS

更新日期：2018-05-11 00:00:00

abstract：:High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of the ovarian cancer deaths, but over the last years little improvement in overall survival has been achieved. HGSOC is a molecularly and clinically heterogeneous disease. At genomic level, it represents a C-class malignancy having frequent gene lo...

journal_title：Current oncology reports

authors： Mittempergher L

更新日期：2016-07-01 00:00:00

abstract：:Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, ei...

journal_title：Current oncology reports

authors： Howell SJ,Shalet SM

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to discuss the current role of radiotherapy (RT) for early-stage Hodgkin's lymphoma (HL) in the context of risk-adapted and response-adapted treatment strategy, and describe changes in RT technical approach. RECENT FINDINGS:In low-risk patients, RT could be omitted but, at ...

journal_title：Current oncology reports

authors： Filippi AR,Levis M,Parikh R,Hoppe B

更新日期：2017-05-01 00:00:00

abstract：:The result of a lung cancer screening program should be fewer lung cancer-specific deaths in the screened population. Studies evaluating chest imaging as a screening tool for lung cancer have not shown a reduction in lung cancer-specific mortality to date. The ability of institutions using chest imaging to meet the cr...

journal_title：Current oncology reports

authors： Mazzone PJ,Mekhail T

更新日期：2007-07-01 00:00:00

abstract：:The original version of this article, which published in Current Oncology Reports, Volume 21, Issue 6, June 2019, contained an error in addressing the indication for use of neratinib in early stage breast cancer. ...

journal_title：Current oncology reports

authors： Leone JP,Lin NU

更新日期：2019-05-17 00:00:00