Gastric carcinoma.

abstract：:Accurate, reproducible criteria for determining tumor response and progression after therapy are critical for optimal patient care and effective evaluation of novel therapeutic agents. Currently, the most widely used criteria for determining treatment response in gliomas is based on two-dimensional tumor measurements ...

journal_title：Current oncology reports

authors： Wen PY,Norden AD,Drappatz J,Quant E

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Anaplastic lymphoma kinase (ALK) rearrangements represent a seldom event in non-small cell lung cancer (NSCLC). Given the oncogene alteration, ALK targeting represents the main therapeutic strategy. Here, we review evidence regarding ALK inhibitors (ALKi): clinical activity, safety profiles, financial...

journal_title：Current oncology reports

authors： Tabbò F,Passiglia F,Novello S

更新日期：2021-01-02 00:00:00

abstract：PURPOSE OF REVIEW:The knowledge base of malignant cell growth and resulting targets is rapidly increasing every day. Clonal theory is essential to understand the changes required for a cell to become malignant. These changes are then clues to therapeutic intervention strategies. Immune system optimization is a critical...

journal_title：Current oncology reports

authors： Messerschmidt JL,Bhattacharya P,Messerschmidt GL

更新日期：2017-08-12 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies and future strategies. RECENT FINDINGS:The number of PD-1/PD-L1...

journal_title：Current oncology reports

authors： Oliveira LJC,Gongora ABL,Jardim DLF

更新日期：2020-06-12 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) and the phosphoinositide 3-kinase (PI3K) signaling pathways are commonly deregulated in cancers and promote cellular growth, proliferation, and survival. mTOR is part of two complexes, mTORC1 and mTORC2, with different biochemical structures and substrates specificity. PI3K/AKT...

journal_title：Current oncology reports

authors： Willems L,Tamburini J,Chapuis N,Lacombe C,Mayeux P,Bouscary D

更新日期：2012-04-01 00:00:00

abstract：:Brain metastases seem to be an almost inevitable complication in patients with metastatic melanoma. Except for the rare patients who can undergo successful surgical resection of brain metastases, current management strategies do not appear adequate and result in a poor outcome (median survival, 2-4 months). In recent ...

journal_title：Current oncology reports

authors： Majer M,Samlowski WE

更新日期：2007-09-01 00:00:00

abstract：:Chemotherapy was traditionally perceived to be ineffective for prostate cancer and was only administered to patients with symptomatic hormone-refractory disease. Although previous reviews have confirmed this belief, recent studies have demonstrated significant antitumor activity with chemotherapy regimens. This articl...

journal_title：Current oncology reports

authors： Petrylak DP

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the long scientific background followed to design guidelines and everyday clinical practice applied to melanoma patients. Surgery is the first option to cure melanoma patients (PTS) at initial diagnosis, since primary cutaneous lesions are usually easily resectable. An excisional...

journal_title：Current oncology reports

authors： Testori AAE,Blankenstein SA,van Akkooi ACJ

更新日期：2019-12-19 00:00:00

abstract：:The diagnosis of a gynecological malignancy during pregnancy is rare but not uncommon. Cancer treatment during pregnancy is possible, but both maternal and fetal interests need to be respected. Different treatment plans may be justifiable and multidisciplinary treatment is advised. Clinical trials are virtually imposs...

journal_title：Current oncology reports

authors： Han SN,Verheecke M,Vandenbroucke T,Gziri MM,Van Calsteren K,Amant F

更新日期：2014-12-01 00:00:00

abstract：:Lymphoma is the third most common cancer in children and adolescents. Non-Hodgkin's lymphomas comprise a heterogeneous group of tumors with distinct pathologic and clinical characteristics. Over the past three decades, significant advancements have been made in the molecular characterization of these disorders. With t...

journal_title：Current oncology reports

authors： Shukla NN,Trippett TM

更新日期：2006-09-01 00:00:00

abstract：:Radiation plays an important role in the multimodal management of tumors of the gastrointestinal (GI) system. Intensity-modulated radiation therapy (IMRT) is a technological development that was introduced to limit the acute and late toxicities commonly associated with conventional radiation therapy. Numerous preclini...

journal_title：Current oncology reports

authors： Meyer JJ,Czito BG,Willett CG

更新日期：2008-05-01 00:00:00

abstract：:Primary and metastatic spinal mesenchymal tumors are uncommon lesions. Surgical management of these tumors remains a challenge. En bloc wide resection provides the best chance for local tumor control and long-term survival. However, limitations to this technique include technical considerations (including neurovascula...

journal_title：Current oncology reports

authors： Mody MG,Rao G,Rhines LD

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors (ICI) are only effective in a subset of patients. Here, we will review the rationale and data supporting the combination of PD-1 pathway inhibition with recombinant cytokines and neoantigen-based cancer vaccines that can potentially increase the number of patients who will...

journal_title：Current oncology reports

authors： Barroso-Sousa R,Ott PA

更新日期：2018-11-15 00:00:00

abstract：:Chordomas and chondrosarcomas of the skull base are rare, indolent tumors with a natural history of locally invading their surroundings. Safe, maximal resection is the mainstay of treatment, followed by adjuvant radiation therapy. Even with multimodality therapy, local recurrence remains the most common failure patter...

journal_title：Current oncology reports

authors： Nguyen QN,Chang EL

更新日期：2008-07-01 00:00:00

abstract：:New combinations of chemotherapy with radiotherapy for gastrointestinal cancers are showing evidence that improved outcomes may result from toxicity profiles associated with "targeted" systemic radiosensitizing agents. These new agents are also clinically attractive owing to such factors as oral bioavailability and pa...

journal_title：Current oncology reports

authors： Rich TA,Crane C,Lawson JD,Landry J

更新日期：2005-05-01 00:00:00

abstract：:For the subgroup of patients with inoperable gastrointestinal stromal tumors, progress has been made by the rapid development and approval of the targeted therapy imatinib mesylate. Small round cell sarcomas (SRCT), such as Ewing/primitive neuroectodermal tumor, desmoplastic SRCT, and rhabdomyosarcoma, are chemotherap...

journal_title：Current oncology reports

authors： Hartmann JT,Patel S

更新日期：2005-07-01 00:00:00

abstract：:The prodrug strategy has its own particular real and theoretic obstacles. Clinical strategies and research efforts have tried to approach these problems. The bystander effect, whereby nontransduced cells are affected by simple proximity to those that have received the novel gene, has enabled many prodrug systems to be...

journal_title：Current oncology reports

authors： Smythe WR

更新日期：2000-01-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common soft tissue sarcoma, and most feature abnormalities in two genes encoding the receptor tyrosine kinases (RTKs), KIT, and PDGFRA. The RTK inhibitor imatinib revolutionized treatment in GIST; however, drug resistance remains a challenge. Constitutive autophosph...

journal_title：Current oncology reports

authors： Patel S

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancemen...

journal_title：Current oncology reports

authors： Ho JC,Phan J

更新日期：2017-10-28 00:00:00

abstract：:Neuroblastoma is the most common extracranial tumor of childhood, with about 650 new cases each year in the United States. The clinical course of neuroblastoma is variable and depends on age at diagnosis, staging, histology, and specific genetic abnormalities, such as MYCN oncogene amplification or aberrations of chro...

journal_title：Current oncology reports

authors： Mueller S,Matthay KK

更新日期：2009-11-01 00:00:00

abstract：:Cutaneous melanoma is a significant and increasing clinical problem. Knowing accurately the prognosis in a given patient is critical for treatment decisions and for optimal patient education. In this article we discuss the most current information regarding prognostic factors in early-stage and advanced malignant mela...

journal_title：Current oncology reports

authors： Buzaid AC,Anderson CM

更新日期：2000-07-01 00:00:00

abstract：:Skin cancer is the most common type of cancer in the United States. US incidence of malignant melanoma is increasing faster than any other type of cancer. To minimize increasing morbidity and mortality rates, it is imperative that appropriate screening and early detection of skin cancer become more widespread. All phy...

journal_title：Current oncology reports

authors： Linden KG

更新日期：2004-11-01 00:00:00

abstract：:With our understanding of human papillomavirus (HPV) and cervical cancer, the availability of HPV testing, and the known limitations of cervical cytology, it is time to reassess cervical cancer screening technologies. This article reviews recent randomized trials comparing primary HPV testing with cervical cytology in...

journal_title：Current oncology reports

authors： Runowicz CD,Garozzo S

更新日期：2008-11-01 00:00:00

abstract：:After decades of reluctance to change surgical approaches, new technologies have created new perspectives for surgery. Initially, the laparoscopic approach was considered to be only one useful for relatively simple procedures as the design of the instruments and the limited access hampered free movements to perform co...

journal_title：Current oncology reports

authors： Verheijen R,Zweemer R

更新日期：2012-12-01 00:00:00

abstract：:Most of the experience with second-line chemotherapy for non-small-cell lung cancer (NSCLC) comes from small phase II trials, which have shown disappointing or inconsistent results. The notable exception has been docetaxel, which has been extensively studied as a second-line therapy for NSCLC. On the basis of consiste...

journal_title：Current oncology reports

authors： Fossella FV

更新日期：2000-01-01 00:00:00

abstract：:Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservat...

journal_title：Current oncology reports

authors： Das P,Crane CH

更新日期：2006-05-01 00:00:00

abstract：:Chronic opioid therapy (defined as greater than 3 months on opioids) is a common practice for those with non-cancer pain, cancer survivors with treatment-related pain, and individuals with cancer undergoing disease-modifying therapy with a survival that can be for a year or more. Recent studies have found unique long-...

journal_title：Current oncology reports

authors： Davis MP,Mehta Z

更新日期：2016-12-01 00:00:00

abstract：:The introduction of targeted therapies, specifically those that target the VEGF receptor (VEGFR), PDGF receptor (PDGFR) and the mTOR pathways, has significantly changed the approach to patients with unresectable renal cell cancer (RCC). However, drug resistance develops through bypassing of targeted pathways. Regorafe...

journal_title：Current oncology reports

authors： Zaki K,Aslam S,Eisen T

更新日期：2013-04-01 00:00:00

abstract：:Aflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic effects that functions as a decoy receptor to bind vascular endothelial growth factors A and B and placental growth factor. Its unique mechanism of action with respect to o...

journal_title：Current oncology reports

authors： Ciombor KK,Berlin J

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Older adults with cancer have complex medical needs and often experience higher rates of treatment-related toxicities compared to their younger counterparts. The advent of health information technologies can address multiple gaps in the care of this population. We review the role of existing and emerg...

journal_title：Current oncology reports

authors： Loh KP,McHugh C,Mohile SG,Mustian K,Flannery M,Klepin H,Schnall R,Culakova E,Ramsdale E

更新日期：2018-03-06 00:00:00