Abstract：
:Most of the experience with second-line chemotherapy for non-small-cell lung cancer (NSCLC) comes from small phase II trials, which have shown disappointing or inconsistent results. The notable exception has been docetaxel, which has been extensively studied as a second-line therapy for NSCLC. On the basis of consistent phase II activity, two large randomized phase III trials were conducted for patients with advanced NSCLC that had progressed either on or after first-line platinum-based therapy. In one trial, docetaxel, at either 100 or 75 mg/m(2), was compared with a regimen of either vinorelbine or ifosfamide. In the second trial, docetaxel 75 to 100 mg/m(2) was compared with best supportive care. Both trials showed significant improvement in survival, time to progression, and quality of life in the patients receiving docetaxel versus the control therapy. Based on these two large trials, it appears that the use of second-line therapy with single-agent docetaxel at a dose of 75 mg/m(2) every 3 weeks is a reasonable practice in patients who maintain a good performance status.
journal_name
Curr Oncol Repjournal_title
Current oncology reportsauthors
Fossella FVdoi
10.1007/s11912-000-0016-xkeywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
96-101issue
1eissn
1523-3790issn
1534-6269journal_volume
2pub_type
杂志文章,评审abstract：:With our understanding of human papillomavirus (HPV) and cervical cancer, the availability of HPV testing, and the known limitations of cervical cytology, it is time to reassess cervical cancer screening technologies. This article reviews recent randomized trials comparing primary HPV testing with cervical cytology in...
journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2008-11-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2017-11-06 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2000-09-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2008-09-01 00:00:00
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journal_title：Current oncology reports
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更新日期：2004-05-01 00:00:00
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journal_title：Current oncology reports
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更新日期：2001-11-01 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Current oncology reports
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更新日期：2010-01-01 00:00:00
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journal_title：Current oncology reports
pub_type： 已发布勘误
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更新日期：2019-05-17 00:00:00
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2017-08-12 00:00:00
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journal_title：Current oncology reports
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journal_title：Current oncology reports
pub_type： 杂志文章,评审
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更新日期：2001-05-01 00:00:00
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journal_title：Current oncology reports
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更新日期：2006-07-01 00:00:00
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更新日期：2019-11-07 00:00:00
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-09-07 00:00:00
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pub_type： 杂志文章,收录出版,评审
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更新日期：2005-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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更新日期：2017-02-01 00:00:00
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