Therapeutic advances for glioblastoma multiforme: current status and future prospects.

abstract：:High-grade serous ovarian carcinoma (HGSOC) accounts for the majority of the ovarian cancer deaths, but over the last years little improvement in overall survival has been achieved. HGSOC is a molecularly and clinically heterogeneous disease. At genomic level, it represents a C-class malignancy having frequent gene lo...

journal_title：Current oncology reports

authors： Mittempergher L

更新日期：2016-07-01 00:00:00

abstract：:There has been much development in the field of targeted therapy for melanoma stemming from efforts to decrease treatment-related toxicities and enhance specific cytotoxicity. This review focuses on three modalities of targeted melanoma therapy based on the biology of the targeting mechanism. The first of these modali...

journal_title：Current oncology reports

authors： Brown CK,Kirkwood JM

更新日期：2001-07-01 00:00:00

abstract：:Variant forms of bladder cancer are non-urothelial neoplasms or urothelial carcinomas mixed with other histologies. Compared to pure urothelial carcinoma, they all present with a high stage and grade. Prognosis is variable and there is a lack of evidence regarding the ideal treatment approach, because of their relativ...

journal_title：Current oncology reports

authors： Pons F,Orsola A,Morote J,Bellmunt J

更新日期：2011-06-01 00:00:00

abstract：:The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of me...

journal_title：Current oncology reports

authors： Kounalakis N,Goydos JS

更新日期：2005-09-01 00:00:00

abstract：:Hypogonadism is common throughout the illness trajectory of patients with cancer. About two thirds of male patients with advanced cancer have hypothalamic-pituitary-gonadal dysfunction and low testosterone levels. Chronic inflammation, comorbidities, cachexia, chemotherapy, and medications such as opioids, megestrol a...

journal_title：Current oncology reports

authors： Dev R,Bruera E,Del Fabbro E

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Surgical management of locally advanced oral cavity squamous cell carcinomas (OCSCC) has long been recognized as a primary treatment modality. Technological advances have led to significant improvements in our surgical approach, from improvement in the visualization of tumors to more efficient and pre...

journal_title：Current oncology reports

authors： Yao CMKL,Chang EI,Lai SY

更新日期：2019-11-07 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors (ICI) are only effective in a subset of patients. Here, we will review the rationale and data supporting the combination of PD-1 pathway inhibition with recombinant cytokines and neoantigen-based cancer vaccines that can potentially increase the number of patients who will...

journal_title：Current oncology reports

authors： Barroso-Sousa R,Ott PA

更新日期：2018-11-15 00:00:00

abstract：:The RAS-RAF-MEK-ERK pathway is considered to be the most important signal transduction pathway in melanoma, and alterations in this pathway via various genetic mutations, such as BRAF and NRAS mutations, are known to be important drivers of melanomagenesis. As MEK is an essential intermediary kinase protein within thi...

journal_title：Current oncology reports

authors： Salama AK,Kim KB

更新日期：2013-10-01 00:00:00

abstract：:Patients with head and neck cancers are excellent candidates for gene therapy. With few effective alternatives for patients with recurrent or locally metastatic disease, gene therapy offers a new approach for local control and the possibility to enhance other treatment modalities as well. Different therapeutic genes, ...

journal_title：Current oncology reports

authors： Clayman GL,Dreiling L

更新日期：1999-01-01 00:00:00

abstract：:The establishment of the Intergroup Rhabdomyosarcoma Study (IRS) Committee in 1972 by three extant American pediatric cooperative groups initiated five generations of studies in the multidisciplinary treatment of soft-tissue sarcomas. Taking the lead from the use of vincristine, actinomycin-D, and cyclophosphamide (VA...

journal_title：Current oncology reports

authors： Ruymann FB

更新日期：2003-11-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common soft tissue sarcoma, and most feature abnormalities in two genes encoding the receptor tyrosine kinases (RTKs), KIT, and PDGFRA. The RTK inhibitor imatinib revolutionized treatment in GIST; however, drug resistance remains a challenge. Constitutive autophosph...

journal_title：Current oncology reports

authors： Patel S

更新日期：2013-08-01 00:00:00

abstract：:For a variety of medical conditions and procedures, a higher volume-better outcome relationship has been hypothesized for over 25 years. An extensive, consistent body of literature supports a relationship between hospital volume and short-term outcomes for cancers treated with technologically complex surgical procedur...

journal_title：Current oncology reports

authors： Hillner BE

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Although surgery for lung cancer was not common before the early twentieth century, it has enjoyed remarkable progress since then both in type of resection and technical approach. This has been coupled with significant technological advances. Here, we will review the history and evolution of this rela...

journal_title：Current oncology reports

authors： Abbas AE

更新日期：2018-11-13 00:00:00

abstract：:Many women undergo mastectomy as treatment of their breast cancer either because of personal preference or because of tumor-related factors making mastectomy the preferred surgical option. The use of postmastectomy radiation therapy has been shown to decrease the risk of local recurrence and in some cases improve over...

journal_title：Current oncology reports

authors： Lyons JA,Sherertz T

更新日期：2014-01-01 00:00:00

abstract：:Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over 150,000 patients in the United States suffer from breathlessness and diminished quality of life due to MPE each year. Current management strategies are of mostly palliative value and focus on symptom control; they do not addr...

journal_title：Current oncology reports

authors： Bradshaw M,Mansfield A,Peikert T

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We aim to summarise the available evidence on systemic therapies for advanced anal cancer. RECENT FINDINGS:There is no universal consensus on the management of this condition and the prognosis remains poor. Nevertheless, significant progress has been recently made including completion of the first, e...

journal_title：Current oncology reports

authors： Sclafani F,Rao S

更新日期：2018-05-04 00:00:00

abstract：:Pediatric medicine is moving toward a greater appreciation that the delivery of quality medical care involves a partnership including the health care team, the child, and the family. Pediatric medicine now emphasizes the importance of information exchange among these groups. This paper discusses two models for communi...

journal_title：Current oncology reports

authors： Weidner NJ

更新日期：2007-11-01 00:00:00

abstract：:Colon cancer remains the third most common cancer, and cause of cancer-related death in the United States. Greater public awareness and acceptance of screening programs have contributed significantly to increasingly earlier detection of colon cancer and decreased mortality. Advances made in the understanding of this d...

journal_title：Current oncology reports

authors： Kumar SK,Goldberg RM

更新日期：2001-03-01 00:00:00

abstract：:Concurrent radiation therapy and chemotherapy is the primary treatment for patients with squamous cell tumors of the anal canal, and is also employed in the neoadjuvant setting for patients with stage II and III adenocarcinoma of the rectum. There is constant clinical study involving modifications of chemoradiotherapy...

journal_title：Current oncology reports

authors： Meyer J,Balch G,Willett C,Czito B

更新日期：2011-06-01 00:00:00

abstract：:With our understanding of human papillomavirus (HPV) and cervical cancer, the availability of HPV testing, and the known limitations of cervical cytology, it is time to reassess cervical cancer screening technologies. This article reviews recent randomized trials comparing primary HPV testing with cervical cytology in...

journal_title：Current oncology reports

authors： Runowicz CD,Garozzo S

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to highlight the clinical development of PD-1 and PD-L1 inhibitors in cancer therapy. We focus on detailing the registration trials that have led to FDA-approved indications of anti-PD-1 and anti-PD-L1 therapies and future strategies. RECENT FINDINGS:The number of PD-1/PD-L1...

journal_title：Current oncology reports

authors： Oliveira LJC,Gongora ABL,Jardim DLF

更新日期：2020-06-12 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we seek to summarize the literature concerning the use of single-cell RNA-sequencing for CNS gliomas. RECENT FINDINGS:Single-cell analysis has revealed complex tumor heterogeneity, subpopulations of proliferating stem-like cells and expanded our view of tumor microenvironment influenc...

journal_title：Current oncology reports

authors： Johnson E,Dickerson KL,Connolly ID,Hayden Gephart M

更新日期：2018-04-10 00:00:00

abstract：PURPOSE OF REVIEW:Opioids are the only class of drug with the proven ability to control severe pain. The introduction of stringent opioid prescribing restrictions has inevitably impacted upon the ability of those prescribing opioids for advanced life-limited disease to practice as previously and could limit the supply ...

journal_title：Current oncology reports

authors： Pinkerton R,Mitchell G,Hardy J

更新日期：2020-03-13 00:00:00

abstract：:The prodrug strategy has its own particular real and theoretic obstacles. Clinical strategies and research efforts have tried to approach these problems. The bystander effect, whereby nontransduced cells are affected by simple proximity to those that have received the novel gene, has enabled many prodrug systems to be...

journal_title：Current oncology reports

authors： Smythe WR

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in cervical cancer screening and treatment have resulted in high cure rates in developed countries for early-stage disease. Current research focuses on minimizing morbidity and maximizing quality of life. RECENT FINDINGS:Imaging has been disappointing in identifying small volume metastases. ...

journal_title：Current oncology reports

authors： Zigras T,Lennox G,Willows K,Covens A

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors have revolutionised the treatment of multiple malignancies and have a growing list of indications. As our familiarity with these agents grows, so does our understanding of their unique spectrum of toxicities. Here, we will review the literature regarding the toxicities of ...

journal_title：Current oncology reports

authors： Palmieri DJ,Carlino MS

更新日期：2018-07-31 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to provide clinicians and pathologists with an understanding of the aetiopathology, pathogenesis and classification of vulval neoplasia and their molecular correlates. RECENT FINDINGS:There is an increased understanding of subcellular changes in vulvar malignancies. These p...

journal_title：Current oncology reports

authors： Williams A,Syed S,Velangi S,Ganesan R

更新日期：2019-08-15 00:00:00

abstract：:Results of treatment for patients with non-Hodgkin's lymphomas have significantly improved over the last decade, especially following the discovery that anti-CD20 antibody therapy can significantly change the outlook for patients with both aggressive and indolent lymphomas. Although investigators have previously attem...

journal_title：Current oncology reports

authors： Hagemeister FB

更新日期：2010-11-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) and the phosphoinositide 3-kinase (PI3K) signaling pathways are commonly deregulated in cancers and promote cellular growth, proliferation, and survival. mTOR is part of two complexes, mTORC1 and mTORC2, with different biochemical structures and substrates specificity. PI3K/AKT...

journal_title：Current oncology reports

authors： Willems L,Tamburini J,Chapuis N,Lacombe C,Mayeux P,Bouscary D

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of less than 2 years despite the standard of care treatment of 6 weeks of chemoradiotherapy. We review the data investigating hypofractionated radiotherapy (HFRT) in the treatment of newly diagnosed ...

journal_title：Current oncology reports

authors： Azoulay M,Shah J,Pollom E,Soltys SG

更新日期：2017-09-01 00:00:00